Detailed information of TA system TA113411

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2148766..2148962
• Replicon: chromosome
• Accession: NZ_CP033214
• Organism: Clostridioides difficile strain 12038

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: EBL90_RS10540
• Protein ID: WP_003424190.1
• Coordinates: 2148810..2148962 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2148766..2148866 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBL90_RS10510	2143921..2144115	-	195	WP_003424168.1	hypothetical protein	-
EBL90_RS10520	2144652..2145032	-	381	WP_003424180.1	hypothetical protein	-
EBL90_RS10525	2145025..2145282	-	258	WP_003424182.1	hypothetical protein	-
EBL90_RS10530	2145269..2145502	-	234	WP_003424184.1	hypothetical protein	-
EBL90_RS10535	2145690..2145878	+	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
-	2148766..2148866	+	101	NuclAT_0	-	Antitoxin
EBL90_RS10540	2148810..2148962	-	153	WP_003424190.1	hypothetical protein	Toxin
EBL90_RS19265	2149482..2149724	+	243	WP_003424191.1	hypothetical protein	-
EBL90_RS19270	2149790..2150335	+	546	WP_077699404.1	site-specific integrase	-
EBL90_RS10555	2150880..2151725	+	846	WP_003424194.1	DUF4878 domain-containing protein	-
EBL90_RS10560	2151949..2152113	-	165	WP_003424195.1	hypothetical protein	-
EBL90_RS10565	2152645..2152976	-	332	Protein_1915	carboxymuconolactone decarboxylase family protein	-
EBL90_RS10570	2153236..2153877	-	642	WP_003424198.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2133713..2158645	24932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T113411 WP_003424190.1 NZ_CP033214:c2148962-2148810 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T113411 NZ_CP033214:c2148962-2148810 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGTATATTAGCAAGTTTAGTTGCCAGTTTAATAGTTTACTTAACTAGTAAGTTATTTAAAAA
AGTAAAAAGCCACTCTGGCAGGAGTGACTTTAGTTTTGAACTAGAAATCAAGTTCAAAAAGAATAAACATTAG

Antitoxin

Nucleotide

• Length: 101 bp

>AT113411 NZ_CP033214:2148766-2148866 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin