Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4569390..4569802 Replicon chromosome
Accession NZ_CP032679
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag D7U33_RS21990 Protein ID WP_000132601.1
Coordinates 4569390..4569731 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4569726..4569802 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7U33_RS21980 4566803..4567849 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
D7U33_RS21985 4567849..4569228 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
D7U33_RS21990 4569390..4569731 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- 4569726..4569802 + 77 NuclAT_14 - Antitoxin
- 4569726..4569802 + 77 NuclAT_14 - Antitoxin
- 4569726..4569802 + 77 NuclAT_14 - Antitoxin
- 4569726..4569802 + 77 NuclAT_14 - Antitoxin
- 4569726..4569802 + 77 NuclAT_15 - Antitoxin
- 4569726..4569802 + 77 NuclAT_15 - Antitoxin
- 4569726..4569802 + 77 NuclAT_15 - Antitoxin
- 4569726..4569802 + 77 NuclAT_15 - Antitoxin
D7U33_RS21995 4569959..4571353 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
D7U33_RS22000 4571350..4572939 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4562305..4571353 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T112130 WP_000132601.1 NZ_CP032679:c4569731-4569390 [Escherichia coli str. K-12 substr. MG1655]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T112130 NZ_CP032679:c4569731-4569390 [Escherichia coli str. K-12 substr. MG1655]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 77 bp

>AT112130 NZ_CP032679:4569726-4569802 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References