Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 521196..522433 Replicon chromosome
Accession NZ_CP031247
Organism Streptococcus pneumoniae strain M23734

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag DV129_RS02765 Protein ID WP_000405353.1
Coordinates 521196..521957 (-) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag DV129_RS02770 Protein ID WP_000579613.1
Coordinates 521957..522433 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV129_RS11870 516608..518472 - 1865 Protein_522 relaxase/mobilization nuclease domain-containing protein -
DV129_RS02750 518459..518757 - 299 Protein_523 MobC family plasmid mobilization relaxosome protein -
DV129_RS02755 518833..519192 - 360 WP_000003746.1 hypothetical protein -
DV129_RS02760 520011..521168 - 1158 WP_001213953.1 hypothetical protein -
DV129_RS02765 521196..521957 - 762 WP_000405353.1 zeta toxin family protein Toxin
DV129_RS02770 521957..522433 - 477 WP_000579613.1 helix-turn-helix domain-containing protein Antitoxin
DV129_RS02775 522876..523331 - 456 WP_000500471.1 hypothetical protein -
DV129_RS02780 523606..525343 - 1738 Protein_529 alpha-glycosidase -
DV129_RS02785 525506..526390 - 885 WP_000710109.1 diacylglycerol kinase family lipid kinase -
DV129_RS02790 526502..527356 - 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 507165..538210 31045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29043.02 Da        Isoelectric Point: 7.2344

>T108716 WP_000405353.1 NZ_CP031247:c521957-521196 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLHELLFGEWSQVEKEML
RVGEKRLNELLEK

Download         Length: 762 bp

>T108716 NZ_CP031247:c521957-521196 [Streptococcus pneumoniae]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGAGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGTAAAATGGTAGAGTCTTTAGTAACAGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGCTGTCCTATCTGAGCACTCTTATTCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACACCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATTTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCATGAGTTATTGTTTGGAGAGTGGAGTCAGGTAGAAAAGGAGATGTTG
AGGGTAGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18249.67 Da        Isoelectric Point: 4.3462

>AT108716 WP_000579613.1 NZ_CP031247:c522433-521957 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT108716 NZ_CP031247:c522433-521957 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCTGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References