Detailed information of TA system TA106363

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3601906..3602320
• Replicon: chromosome
• Accession: NZ_CP029682
• Organism: Salmonella sp. FORC89

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: FORC89_RS17735
• Protein ID: WP_000994230.1
• Coordinates: 3602063..3602320 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3601906..3602238 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC89_RS17695	3597167..3597664	-	498	WP_016695185.1	Saf-pilin pilus formation protein	-
FORC89_RS17700	3598427..3598997	-	571	Protein_3461	integrase core domain-containing protein	-
FORC89_RS17705	3598918..3599127	-	210	WP_001676010.1	hypothetical protein	-
FORC89_RS17710	3599180..3599494	+	315	WP_072100769.1	SymE family type I addiction module toxin	-
FORC89_RS17715	3599561..3599839	-	279	WP_012543321.1	hypothetical protein	-
FORC89_RS17720	3600156..3600623	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
FORC89_RS17725	3600620..3600937	-	318	WP_001751277.1	hypothetical protein	-
FORC89_RS17730	3601495..3601728	-	234	WP_124084119.1	hypothetical protein	-
-	3601906..3602238	-	333	-	-	Antitoxin
FORC89_RS17735	3602063..3602320	+	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
FORC89_RS17740	3602386..3602832	-	447	WP_000171102.1	hypothetical protein	-
FORC89_RS17745	3602829..3606203	-	3375	Protein_3470	RHS domain-containing protein	-
FORC89_RS17750	3606203..3606709	-	507	Protein_3471	phage late control D family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3589271..3606125	16854
	-	flank	IS/Tn	-	-	3598427..3598705	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T106363 WP_000994230.1 NZ_CP029682:3602063-3602320 [Salmonella sp. FORC89]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T106363 NZ_CP029682:3602063-3602320 [Salmonella sp. FORC89]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin

Nucleotide

• Length: 333 bp

>AT106363 NZ_CP029682:c3602238-3601906 [Salmonella sp. FORC89]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin