Detailed information of TA system TA105790

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1937153..1937362
• Replicon: chromosome
• Accession: NZ_CP029566
• Organism: Clostridioides difficile strain CBA7204

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: Q182K5
• Locus tag: DF008_RS09060
• Protein ID: WP_004454815.1
• Coordinates: 1937204..1937362 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	1937153..1937287 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF008_RS09045	1932911..1934539	+	1629	WP_004454813.1	aspartate 4-decarboxylase	-
DF008_RS09050	1934660..1935655	+	996	WP_003431031.1	asparaginase	-
DF008_RS09055	1935844..1936227	-	384	WP_021372541.1	BlaI/MecI/CopY family transcriptional regulator	-
-	1937153..1937287	+	135	NuclAT_0	-	Antitoxin
DF008_RS09060	1937204..1937362	-	159	WP_004454815.1	hypothetical protein	Toxin
DF008_RS09065	1937721..1939091	-	1371	WP_021373596.1	cell wall-binding protein Cwp29	-
DF008_RS09070	1939435..1940028	+	594	WP_165475517.1	tyrosine-type recombinase/integrase	-
DF008_RS09075	1940058..1940330	+	273	WP_004454820.1	tyrosine-type recombinase/integrase	-
DF008_RS09080	1940693..1940773	-	81	Protein_1781	VOC family protein	-
DF008_RS09085	1940813..1941481	-	669	WP_159376284.1	VanZ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5996.20 Da
• Isoelectric Point: 11.3102

>T105790 WP_004454815.1 NZ_CP029566:c1937362-1937204 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T105790 NZ_CP029566:c1937362-1937204 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT105790 NZ_CP029566:1937153-1937287 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Toxin

• AlphaFold DB: A0A125V849

Antitoxin