Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1937153..1937362 Replicon chromosome
Accession NZ_CP029566
Organism Clostridioides difficile strain CBA7204

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag DF008_RS09060 Protein ID WP_004454815.1
Coordinates 1937204..1937362 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 1937153..1937287 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DF008_RS09045 1932911..1934539 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
DF008_RS09050 1934660..1935655 + 996 WP_003431031.1 asparaginase -
DF008_RS09055 1935844..1936227 - 384 WP_021372541.1 BlaI/MecI/CopY family transcriptional regulator -
- 1937153..1937287 + 135 NuclAT_0 - Antitoxin
DF008_RS09060 1937204..1937362 - 159 WP_004454815.1 hypothetical protein Toxin
DF008_RS09065 1937721..1939091 - 1371 WP_021373596.1 cell wall-binding protein Cwp29 -
DF008_RS09070 1939435..1940028 + 594 WP_165475517.1 tyrosine-type recombinase/integrase -
DF008_RS09075 1940058..1940330 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
DF008_RS09080 1940693..1940773 - 81 Protein_1781 VOC family protein -
DF008_RS09085 1940813..1941481 - 669 WP_159376284.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T105790 WP_004454815.1 NZ_CP029566:c1937362-1937204 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T105790 NZ_CP029566:c1937362-1937204 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT105790 NZ_CP029566:1937153-1937287 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References