Detailed information of TA system TA105783

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 885631..885845
• Replicon: chromosome
• Accession: NZ_CP029566
• Organism: Clostridioides difficile strain CBA7204

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: -
• Locus tag: DF008_RS04155
• Protein ID: WP_032508407.1
• Coordinates: 885631..885792 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	885712..885845 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF008_RS04110	880819..881109	+	291	WP_021358995.1	HK97 gp10 family phage protein	-
DF008_RS04115	881219..882025	+	807	WP_009888838.1	hypothetical protein	-
DF008_RS04125	882374..882811	+	438	WP_009901504.1	hypothetical protein	-
DF008_RS04130	882804..882980	+	177	WP_016728451.1	hypothetical protein	-
DF008_RS04135	882981..884291	+	1311	WP_021363494.1	phage tail sheath family protein	-
DF008_RS04140	884308..884778	+	471	WP_003429851.1	phage tail tube protein	-
DF008_RS04145	884850..885290	+	441	WP_003429853.1	phage portal protein	-
DF008_RS04155	885631..885792	+	162	WP_032508407.1	hypothetical protein	Toxin
-	885712..885845	-	134	NuclAT_1	-	Antitoxin
-	885712..885845	-	134	NuclAT_2	-	Antitoxin
-	886190..886295	-	106	NuclAT_4	-	-
-	886190..886295	-	106	NuclAT_5	-	-
DF008_RS04160	887727..887897	+	171	WP_021361718.1	ribbon-helix-helix domain-containing protein	-
DF008_RS04165	888025..888867	+	843	WP_021367639.1	BRO family, N-terminal domain protein	-
DF008_RS18545	888922..889077	+	156	WP_021367640.1	hypothetical protein	-
DF008_RS04170	889634..890404	+	771	WP_018112719.1	SHOCT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	855128..919140	64012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T105783 WP_032508407.1 NZ_CP029566:885631-885792 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCIICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T105783 NZ_CP029566:885631-885792 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCATAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT105783 NZ_CP029566:c885845-885712 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Antitoxin