Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 471280..471485 Replicon chromosome
Accession NZ_CP029566
Organism Clostridioides difficile strain CBA7204

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag DF008_RS02135 Protein ID WP_009896140.1
Coordinates 471280..471432 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 471412..471485 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DF008_RS02115 466742..467026 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
DF008_RS02120 467049..468566 - 1518 WP_009896137.1 recombinase family protein -
DF008_RS02125 468691..469512 - 822 WP_009896138.1 tetratricopeptide repeat protein -
DF008_RS02130 469703..471130 + 1428 WP_021418138.1 cell wall-binding protein Cwp26 -
DF008_RS02135 471280..471432 + 153 WP_009896140.1 hypothetical protein Toxin
- 471412..471485 - 74 NuclAT_7 - Antitoxin
DF008_RS02140 474049..474273 - 225 WP_003438172.1 helix-turn-helix domain-containing protein -
DF008_RS02145 474945..475100 + 156 WP_009902313.1 hypothetical protein -
DF008_RS02155 475346..475597 + 252 WP_003419270.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T105781 WP_009896140.1 NZ_CP029566:471280-471432 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T105781 NZ_CP029566:471280-471432 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT105781 NZ_CP029566:c471485-471412 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References