Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2550608..2550788 Replicon chromosome
Accession NZ_CP029474
Organism Staphylococcus aureus strain USA 100 isolate 30-47

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag DKK89_RS12910 Protein ID WP_001801861.1
Coordinates 2550608..2550703 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2550731..2550788 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKK89_RS12880 2545771..2546421 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
DKK89_RS12885 2546502..2547497 + 996 WP_000070642.1 DUF4352 domain-containing protein -
DKK89_RS12890 2547572..2548198 + 627 WP_000669024.1 hypothetical protein -
DKK89_RS12895 2548239..2548580 + 342 WP_000627540.1 DUF3969 family protein -
DKK89_RS12900 2548681..2549253 + 573 WP_000414216.1 hypothetical protein -
DKK89_RS12905 2549451..2550463 - 1013 Protein_2413 IS3 family transposase -
DKK89_RS12910 2550608..2550703 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2550731..2550788 - 58 - - Antitoxin
DKK89_RS12915 2550826..2550927 + 102 WP_001792025.1 hypothetical protein -
DKK89_RS12920 2550905..2551066 - 162 Protein_2416 transposase -
DKK89_RS12925 2551057..2551551 - 495 Protein_2417 transposase -
DKK89_RS12930 2552003..2553232 - 1230 WP_000072627.1 restriction endonuclease subunit S -
DKK89_RS12935 2553225..2554781 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
DKK89_RS12940 2554945..2555079 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 2545012..2580293 35281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T105702 WP_001801861.1 NZ_CP029474:2550608-2550703 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T105702 NZ_CP029474:2550608-2550703 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT105702 NZ_CP029474:c2550788-2550731 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References