Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2817786..2817995 Replicon chromosome
Accession NZ_CP029345
Organism Clostridioides difficile strain DSM 104452

Toxin (Protein)


Gene name CD2517.1 Uniprot ID Q182K5
Locus tag CDIF104452_RS13325 Protein ID WP_004454815.1
Coordinates 2817837..2817995 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name RCd8
Locus tag -
Coordinates 2817786..2817920 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF104452_RS13310 (2813413) 2813413..2815041 + 1629 WP_004454813.1 aspartate 4-decarboxylase -
CDIF104452_RS13315 (2815162) 2815162..2816157 + 996 WP_003431031.1 asparaginase -
CDIF104452_RS13320 (2816346) 2816346..2816594 - 249 WP_231298879.1 BlaI/MecI/CopY family transcriptional regulator -
- (2817786) 2817786..2817920 + 135 NuclAT_1 - Antitoxin
- (2817786) 2817786..2817920 + 135 NuclAT_1 - Antitoxin
- (2817786) 2817786..2817920 + 135 NuclAT_2 - Antitoxin
CDIF104452_RS13325 (2817837) 2817837..2817995 - 159 WP_004454815.1 hypothetical protein Toxin
CDIF104452_RS13330 (2818354) 2818354..2819724 - 1371 WP_009897709.1 cell wall-binding protein Cwp29 -
CDIF104452_RS13335 (2820160) 2820160..2820246 + 87 WP_231298880.1 hypothetical protein -
CDIF104452_RS13340 (2820776) 2820776..2821048 + 273 WP_004454820.1 tyrosine-type recombinase/integrase -
CDIF104452_RS13345 (2821366) 2821366..2822034 - 669 WP_009897711.1 VanZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5996.20 Da        Isoelectric Point: 11.3102

>T105485 WP_004454815.1 NZ_CP029345:c2817995-2817837 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Download         Length: 159 bp

>T105485 NZ_CP029345:c2817995-2817837 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATATAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin


Download         Length: 135 bp

>AT105485 NZ_CP029345:2817786-2817920 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125V849

Antitoxin

Download structure file

References