Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1321240..1321445 Replicon chromosome
Accession NZ_CP029345
Organism Clostridioides difficile strain DSM 104452

Toxin (Protein)


Gene name CD1233.1 Uniprot ID A0A069A9H6
Locus tag CDIF104452_RS06350 Protein ID WP_009896140.1
Coordinates 1321240..1321392 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name SQ808
Locus tag -
Coordinates 1321372..1321445 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDIF104452_RS06330 (1317180) 1317180..1317464 - 285 WP_003419254.1 sigma-70 family RNA polymerase sigma factor -
CDIF104452_RS06335 (1317487) 1317487..1319004 - 1518 WP_003438169.1 recombinase family protein -
CDIF104452_RS06340 (1319129) 1319129..1319950 - 822 WP_003438170.1 tetratricopeptide repeat protein -
CDIF104452_RS06345 (1320141) 1320141..1321168 + 1028 Protein_1156 cell wall-binding protein Cwp26 -
CDIF104452_RS06350 (1321240) 1321240..1321392 + 153 WP_009896140.1 hypothetical protein Toxin
- (1321372) 1321372..1321445 - 74 NuclAT_6 - Antitoxin
- (1321372) 1321372..1321445 - 74 NuclAT_6 - Antitoxin
- (1321372) 1321372..1321445 - 74 NuclAT_9 - Antitoxin
CDIF104452_RS06355 (1323086) 1323086..1323310 - 225 WP_021367699.1 helix-turn-helix transcriptional regulator -
CDIF104452_RS06360 (1323989) 1323989..1324144 + 156 WP_021363414.1 hypothetical protein -
CDIF104452_RS06365 (1324423) 1324423..1324641 + 219 WP_009889000.1 hypothetical protein -
CDIF104452_RS06370 (1325298) 1325298..1325492 + 195 WP_021367700.1 hypothetical protein -
CDIF104452_RS06375 (1325861) 1325861..1326244 - 384 WP_003433385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5811.96 Da        Isoelectric Point: 11.1039

>T105480 WP_009896140.1 NZ_CP029345:1321240-1321392 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Download         Length: 153 bp

>T105480 NZ_CP029345:1321240-1321392 [Clostridioides difficile]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin


Download         Length: 74 bp

>AT105480 NZ_CP029345:c1321445-1321372 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069A9H6

Antitoxin

Download structure file

References