Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 1183974..1184189 | Replicon | chromosome |
| Accession | NZ_CP029345 | ||
| Organism | Clostridioides difficile strain DSM 104452 | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | CDIF104452_RS05650 | Protein ID | WP_011861731.1 |
| Coordinates | 1183974..1184117 (+) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd8 | ||
| Locus tag | - | ||
| Coordinates | 1184039..1184189 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CDIF104452_RS05625 (1179646) | 1179646..1179993 | + | 348 | WP_009898409.1 | hypothetical protein | - |
| CDIF104452_RS05630 (1180159) | 1180159..1180677 | + | 519 | WP_009898407.1 | DUF5706 domain-containing protein | - |
| CDIF104452_RS05635 (1180741) | 1180741..1182309 | - | 1569 | WP_009898404.1 | hypothetical protein | - |
| CDIF104452_RS05640 (1182303) | 1182303..1182824 | - | 522 | WP_009898403.1 | ImmA/IrrE family metallo-endopeptidase | - |
| CDIF104452_RS05645 (1183526) | 1183526..1183714 | - | 189 | WP_009898401.1 | hypothetical protein | - |
| CDIF104452_RS05650 (1183974) | 1183974..1184117 | + | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| - (1184039) | 1184039..1184189 | - | 151 | NuclAT_1 | - | Antitoxin |
| - (1184043) | 1184043..1184189 | - | 147 | NuclAT_0 | - | - |
| - (1184043) | 1184043..1184189 | - | 147 | NuclAT_0 | - | - |
| - (1184043) | 1184043..1184189 | - | 147 | NuclAT_0 | - | - |
| CDIF104452_RS05655 (1184624) | 1184624..1185001 | + | 378 | WP_021391346.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| CDIF104452_RS05660 (1185111) | 1185111..1185494 | + | 384 | WP_015984867.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| CDIF104452_RS05665 (1185688) | 1185688..1186263 | + | 576 | WP_021360401.1 | GntR family transcriptional regulator | - |
| CDIF104452_RS05670 (1186289) | 1186289..1186702 | + | 414 | WP_009896035.1 | PTS sugar transporter subunit IIA | - |
| CDIF104452_RS05675 (1186706) | 1186706..1187449 | + | 744 | WP_003437997.1 | BtpA/SgcQ family protein | - |
| CDIF104452_RS05680 (1187449) | 1187449..1187919 | + | 471 | WP_003428544.1 | PTS sugar transporter subunit IIB | - |
| CDIF104452_RS05685 (1187936) | 1187936..1188694 | + | 759 | WP_009888882.1 | PTS sugar transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T105476 WP_011861731.1 NZ_CP029345:1183974-1184117 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T105476 NZ_CP029345:1183974-1184117 [Clostridioides difficile]
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
ATGAGCGAATTTTTACTAGGAGTGTTAGCTAGTTTAACAGCTAGCTTTATTACATATATTATTTCCAGAAAAGTAAAAAG
CCACTCTGGCAGGAGTGACTTTGAGCTTGATGTAAAAATCAAGTTTAATAAAAAACGACATTAA
Antitoxin
Download Length: 151 bp
>AT105476 NZ_CP029345:c1184189-1184039 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTTTCTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
