Detailed information of TA system TA105068

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2814599..2814808
• Replicon: chromosome
• Accession: NZ_CP029154
• Organism: Clostridioides difficile strain CD161

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: DDG63_RS21665
• Protein ID: WP_003431040.1
• Coordinates: 2814650..2814808 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2814599..2814733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDG63_RS13365	2809933..2810133	+	201	WP_003431034.1	cold-shock protein	-
DDG63_RS13370	2810564..2811901	+	1338	WP_003431035.1	ATP-binding protein	-
DDG63_RS13375	2811944..2812525	+	582	WP_003431036.1	accessory gene regulator B family protein	-
DDG63_RS13380	2812543..2812704	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
DDG63_RS13385	2812726..2813523	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
DDG63_RS13390	2813520..2813780	-	261	WP_003431039.1	phage holin family protein	-
-	2814599..2814733	+	135	NuclAT_4	-	Antitoxin
DDG63_RS21665	2814650..2814808	-	159	WP_003431040.1	hypothetical protein	Toxin
DDG63_RS13400	2815166..2816536	-	1371	WP_003431041.1	cell wall-binding protein Cwp29	-
DDG63_RS13405	2816818..2816916	+	99	Protein_2506	Arm DNA-binding domain-containing protein	-
DDG63_RS13410	2816935..2817357	+	423	WP_003431042.1	hypothetical protein	-
DDG63_RS13415	2817675..2817860	+	186	WP_107615967.1	tyrosine-type recombinase/integrase	-
DDG63_RS13420	2818223..2818303	-	81	Protein_2509	VOC family protein	-
DDG63_RS13425	2818343..2819011	-	669	WP_003431044.1	VanZ family protein	-
DDG63_RS13430	2819110..2819493	-	384	WP_071599195.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T105068 WP_003431040.1 NZ_CP029154:c2814808-2814650 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T105068 NZ_CP029154:c2814808-2814650 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATGTAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT105068 NZ_CP029154:2814599-2814733 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin