Detailed information of TA system TA105061

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2883482..2883691
• Replicon: chromosome
• Accession: NZ_CP029152
• Organism: Clostridioides difficile strain CDT4

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: DDG61_RS20475
• Protein ID: WP_003431040.1
• Coordinates: 2883533..2883691 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2883482..2883616 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDG61_RS13785	2878816..2879016	+	201	WP_003431034.1	cold-shock protein	-
DDG61_RS13790	2879447..2880784	+	1338	WP_003431035.1	ATP-binding protein	-
DDG61_RS13795	2880827..2881408	+	582	WP_003431036.1	accessory gene regulator B family protein	-
DDG61_RS13800	2881426..2881587	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
DDG61_RS13805	2881609..2882406	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
DDG61_RS13810	2882403..2882663	-	261	WP_003431039.1	phage holin family protein	-
-	2883482..2883616	+	135	NuclAT_2	-	Antitoxin
DDG61_RS20475	2883533..2883691	-	159	WP_003431040.1	hypothetical protein	Toxin
DDG61_RS13820	2884049..2885419	-	1371	WP_003431041.1	cell wall-binding protein Cwp29	-
DDG61_RS13825	2885701..2885799	+	99	Protein_2594	Arm DNA-binding domain-containing protein	-
DDG61_RS13830	2885818..2886240	+	423	WP_003431042.1	hypothetical protein	-
DDG61_RS13835	2886558..2886743	+	186	WP_107615967.1	tyrosine-type recombinase/integrase	-
DDG61_RS13840	2887106..2887186	-	81	Protein_2597	VOC family protein	-
DDG61_RS13845	2887226..2887894	-	669	WP_003431044.1	VanZ family protein	-
DDG61_RS13850	2887993..2888376	-	384	WP_071599195.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T105061 WP_003431040.1 NZ_CP029152:c2883691-2883533 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T105061 NZ_CP029152:c2883691-2883533 [Clostridioides difficile]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATGTAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT105061 NZ_CP029152:2883482-2883616 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin