Detailed information of TA system TA105057

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1819826..1820040
• Replicon: chromosome
• Accession: NZ_CP029152
• Organism: Clostridioides difficile strain CDT4

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: DDG61_RS20375
• Protein ID: WP_003429855.1
• Coordinates: 1819826..1819987 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1819907..1820040 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDG61_RS08800	1815166..1815399	+	234	WP_003433536.1	hypothetical protein	-
DDG61_RS08805	1815409..1815810	+	402	WP_009888836.1	hypothetical protein	-
DDG61_RS08810	1815804..1816151	+	348	WP_003433540.1	hypothetical protein	-
DDG61_RS08815	1816151..1816576	+	426	WP_003433542.1	HK97 gp10 family phage protein	-
DDG61_RS08820	1816569..1817006	+	438	WP_003433544.1	hypothetical protein	-
DDG61_RS20370	1816999..1817175	+	177	WP_003433548.1	hypothetical protein	-
DDG61_RS08830	1817176..1818486	+	1311	WP_003433550.1	phage tail sheath family protein	-
DDG61_RS08835	1818503..1818973	+	471	WP_003429851.1	phage tail tube protein	-
DDG61_RS08840	1819045..1819485	+	441	WP_003429853.1	phage portal protein	-
DDG61_RS20375	1819826..1819987	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1819907..1820040	-	134	NuclAT_0	-	Antitoxin
-	1819907..1820040	-	134	NuclAT_1	-	Antitoxin
-	1820385..1820433	-	49	NuclAT_5	-	-
-	1820385..1820433	-	49	NuclAT_6	-	-
DDG61_RS08855	1821312..1821887	+	576	WP_043897361.1	SHOCT domain-containing protein	-
DDG61_RS08860	1822191..1822364	+	174	WP_003433557.1	hypothetical protein	-
DDG61_RS20195	1822488..1823315	+	828	WP_003433559.1	hypothetical protein	-
DDG61_RS20380	1823364..1823540	+	177	WP_003433561.1	hypothetical protein	-
DDG61_RS08870	1823971..1824531	+	561	WP_021387709.1	ribosomal protein L7/L12	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T105057 WP_003429855.1 NZ_CP029152:1819826-1819987 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T105057 NZ_CP029152:1819826-1819987 [Clostridioides difficile]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT105057 NZ_CP029152:c1820040-1819907 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin