Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 828684..829096 Replicon chromosome
Accession NZ_CP028703
Organism Escherichia coli strain ME8067

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag DBB47_RS04300 Protein ID WP_000132601.1
Coordinates 828684..829025 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 829020..829096 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBB47_RS04290 826097..827143 - 1047 WP_108118850.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
DBB47_RS04295 827143..828522 - 1380 WP_108118568.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
DBB47_RS04300 828684..829025 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- 829020..829096 + 77 NuclAT_14 - Antitoxin
- 829020..829096 + 77 NuclAT_14 - Antitoxin
- 829020..829096 + 77 NuclAT_14 - Antitoxin
- 829020..829096 + 77 NuclAT_14 - Antitoxin
- 829020..829096 + 77 NuclAT_15 - Antitoxin
- 829020..829096 + 77 NuclAT_15 - Antitoxin
- 829020..829096 + 77 NuclAT_15 - Antitoxin
- 829020..829096 + 77 NuclAT_15 - Antitoxin
DBB47_RS04305 829253..830647 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
DBB47_RS04310 830644..832233 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 821599..830647 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T102983 WP_000132601.1 NZ_CP028703:c829025-828684 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T102983 NZ_CP028703:c829025-828684 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 77 bp

>AT102983 NZ_CP028703:829020-829096 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References