Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | AapC-IsoC/- |
| Location | 1071944..1072031 | Replicon | chromosome |
| Accession | NC_000915 | ||
| Organism | Helicobacter pylori 26695 | ||
| T1TAdb ID | TA03831 | ||
Toxin (Protein)
| Gene name | AapC | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 1071944..1071994 (-) | Length | 17 a.a. |
Antitoxin (RNA)
| Gene name | IsoC | ||
| Locus tag | - | ||
| Coordinates | 1071960..1072031 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HP_RS04930 (HP1005) | 1067156..1067470 | + | 315 | WP_000065304.1 | hypothetical protein | - |
| HP_RS04935 | 1067463..1067745 | + | 283 | Protein_963 | YafQ family addiction module toxin | - |
| HP_RS04940 (HP1006) | 1068021..1068545 | - | 525 | WP_025444691.1 | type IV secretory system conjugative DNA transfer family protein | - |
| HP_RS04945 (HP1007) | 1068602..1069929 | - | 1328 | Protein_965 | transposase | - |
| HP_RS04950 (HP1008) | 1069967..1070383 | + | 417 | WP_001862466.1 | IS200/IS605 family transposase | - |
| HP_RS04955 (HP1009) | 1070508..1071303 | - | 796 | Protein_967 | tyrosine-type recombinase/integrase | - |
| - | 1071944..1071994 | - | 51 | - | - | Toxin |
| - | 1071960..1072031 | + | 72 | - | - | Antitoxin |
| HP_RS04965 (HP1010) | 1072429..1074456 | + | 2028 | WP_001078673.1 | RNA degradosome polyphosphate kinase | - |
| HP_RS04970 (HP1011) | 1074493..1075548 | + | 1056 | WP_000967190.1 | quinone-dependent dihydroorotate dehydrogenase | - |
| HP_RS04975 (HP1012) | 1075545..1076879 | + | 1335 | WP_000680224.1 | insulinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1006987..1072139 | 65152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 17 a.a. Molecular weight: 1819.34 Da Isoelectric Point: 8.7990
>T10215 - NC_000915:c1071994-1071944 [Helicobacter pylori 26695]
MRLVIIVLMVSATPLY
MRLVIIVLMVSATPLY
Download Length: 51 bp
>T10215 NC_000915:c1071994-1071944 [Helicobacter pylori 26695]
ATGAGATTAGTAATCATAGTTTTAATGGTATCCGCAACGCCATTATACTAA
ATGAGATTAGTAATCATAGTTTTAATGGTATCCGCAACGCCATTATACTAA
Antitoxin
Download Length: 72 bp
>AT10215 NC_000915:1071960-1072031 [Helicobacter pylori 26695]
GCGGATACCATTAAAACTATGATTACTAATCTCATGTTAGGTTATCTCCTTTTCTGAGGTAACCACCCACTA
GCGGATACCATTAAAACTATGATTACTAATCTCATGTTAGGTTATCTCCTTTTCTGAGGTAACCACCCACTA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10214 | Helicobacter pylori 26695 |
100 |
100 |
1 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Cynthia M Sharma et al. (2010) The primary transcriptome of the major human pathogen Helicobacter pylori. Nature 464(7286):250-5. [PubMed:20164839]