Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | Zor-Orz/- |
| Location | 2953979..2954389 | Replicon | chromosome |
| Accession | NC_002655 | ||
| Organism | Escherichia coli O157:H7 str. EDL933 | ||
| T1TAdb ID | TA04740 | ||
Toxin (Protein)
| Gene name | zorP | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 2953979..2954068 (-) | Length | 30 a.a. |
Antitoxin (RNA)
| Gene name | orzP | ||
| Locus tag | - | ||
| Coordinates | 2954307..2954389 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Z_RS15440 (Z3287) | 2949252..2952881 | + | 3630 | WP_000356841.1 | DUF4132 domain-containing protein | - |
| Z_RS15445 (Z3288) | 2952943..2953260 | + | 318 | WP_000636932.1 | hypothetical protein | - |
| - | 2953979..2954068 | - | 90 | - | - | Toxin |
| - | 2954307..2954389 | + | 83 | - | - | Antitoxin |
| Z_RS15460 (Z3291) | 2954501..2955589 | + | 1089 | WP_001302026.1 | MoxR family ATPase | - |
| Z_RS15465 (Z3292) | 2955600..2957129 | + | 1530 | WP_001294381.1 | hypothetical protein | - |
| Z_RS15470 (Z3293) | 2957148..2957879 | + | 732 | WP_000528951.1 | hypothetical protein | - |
| Z_RS15475 (Z3294) | 2957872..2959008 | + | 1137 | WP_001302810.1 | VWA domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 30 a.a. Molecular weight: 3249.08 Da Isoelectric Point: 6.0104
>T10213 - NC_002655:c2954068-2953979 [Escherichia coli O157:H7 str. EDL933]
MDSLTQKLTVLIAVLELLVALLRLIDLLK
MDSLTQKLTVLIAVLELLVALLRLIDLLK
Download Length: 90 bp
>T10213 NC_002655:c2954068-2953979 [Escherichia coli O157:H7 str. EDL933]
ATGGACTCGCTGACACAAAAGTTAACCGTGCTCATTGCTGTACTGGAGCTATTAGTAGCTCTGTTACGGTTGATTGATTT
GTTGAAGTAA
ATGGACTCGCTGACACAAAAGTTAACCGTGCTCATTGCTGTACTGGAGCTATTAGTAGCTCTGTTACGGTTGATTGATTT
GTTGAAGTAA
Antitoxin
Download Length: 83 bp
>AT10213 NC_002655:2954307-2954389 [Escherichia coli O157:H7 str. EDL933]
GTTGGAACACGATGTTGCACAGGCTGTGGTGTTAGGCCTGAAAATAGTAAATAAAAGAACCTGCCTCACCAGCAGGTTTT
TTT
GTTGGAACACGATGTTGCACAGGCTGTGGTGTTAGGCCTGAAAATAGTAAATAAAAGAACCTGCCTCACCAGCAGGTTTT
TTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6361 | Escherichia coli O157:H7 str. EDL933 |
96.552 |
100 |
0.966 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Jia Wen et al. (2014) The ZorO-OrzO type I toxin-antitoxin locus: repression by the OrzO antitoxin. Nucleic Acids Research 42(3):1930-46. [PubMed:24203704]