Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | aapA-IsoA/- |
| Location | 1503082..1503224 | Replicon | chromosome |
| Accession | NC_000915 | ||
| Organism | Helicobacter pylori 26695 | ||
| T1TAdb ID | TA00126 | ||
Toxin (Protein)
| Gene name | AapA3 | Uniprot ID | - |
| Locus tag | - | Protein ID | - |
| Coordinates | 1503132..1503224 (+) | Length | 31 a.a. |
Antitoxin (RNA)
| Gene name | IsoA3 | ||
| Locus tag | - | ||
| Coordinates | 1503082..1503160 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HP_RS07070 (HP1429) | 1498437..1499426 | - | 990 | WP_001121932.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
| HP_RS07075 (HP1430) | 1499410..1501479 | - | 2070 | WP_000131629.1 | ribonuclease J | - |
| HP_RS07080 (HP1431) | 1501517..1502332 | - | 816 | WP_000259453.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
| HP_RS07085 (HP_1432) | 1502586..1502804 | + | 219 | WP_001945164.1 | nickel-binding protein HpnL | - |
| - | 1503082..1503160 | - | 79 | - | - | Antitoxin |
| - | 1503132..1503224 | + | 93 | - | - | Toxin |
| HP_RS07090 (HP1433) | 1503438..1506116 | - | 2679 | WP_000923196.1 | hypothetical protein | - |
| HP_RS07095 (HP1434) | 1506117..1506998 | - | 882 | WP_000889170.1 | formyltetrahydrofolate deformylase | - |
| HP_RS07100 (HP1435) | 1507001..1507879 | - | 879 | WP_000269537.1 | signal peptide peptidase SppA | - |
| HP_RS07105 (HP1436) | 1507950..1508198 | + | 249 | WP_000752241.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 31 a.a. Molecular weight: 3585.36 Da Isoelectric Point: 11.4407
>T10113 - NC_000915:1503132-1503224 [Helicobacter pylori 26695]
MKHKSGKRSWKTLYFEFAFLGLKVIVSVKR
MKHKSGKRSWKTLYFEFAFLGLKVIVSVKR
Download Length: 93 bp
>T10113 NC_000915:1503132-1503224 [Helicobacter pylori 26695]
ATGAAACACAAAAGTGGCAAACGCTCTTGGAAAACATTATACTTTGAGTTTGCTTTTTTGGGGCTTAAAGTGATCGTTTC
TGTGAAACGCTGA
ATGAAACACAAAAGTGGCAAACGCTCTTGGAAAACATTATACTTTGAGTTTGCTTTTTTGGGGCTTAAAGTGATCGTTTC
TGTGAAACGCTGA
Antitoxin
Download Length: 79 bp
>AT10113 NC_000915:c1503160-1503082 [Helicobacter pylori 26695]
CAAGAGCGTTTGCCACTTTTGTGTTTCATGGCATGCTCCTTTTGACATAGGATTTGCCCCATATTGCAACTATGGGGCG
CAAGAGCGTTTGCCACTTTTGTGTTTCATGGCATGCTCCTTTTGACATAGGATTTGCCCCATATTGCAACTATGGGGCG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10085 | Helicobacter pylori 26695 |
60 |
100 |
0.6 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Sara Masachis et al. (2019) A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA. ELife 8:e47549. [PubMed:31411564]