Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2602972..2603945 Replicon chromosome
Accession NZ_CP028320
Organism Escherichia coli O18:H1 strain CFSAN067215

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C7X15_RS12990 Protein ID WP_135801351.1
Coordinates 2602972..2603679 (-) Length 236 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag C7X15_RS12995 Protein ID WP_001304368.1
Coordinates 2603679..2603945 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7X15_RS12955 2598329..2599039 - 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
C7X15_RS12960 2599401..2599964 - 564 WP_001327671.1 type 1 fimbrial major subunit FimA -
C7X15_RS12970 2600740..2601522 - 783 WP_001221834.1 SDR family oxidoreductase -
C7X15_RS12975 2601671..2602252 + 582 Protein_2478 LysR family transcriptional regulator -
C7X15_RS12980 2602300..2602713 + 414 WP_000753076.1 acetylxylan esterase -
C7X15_RS12990 2602972..2603679 - 708 WP_135801351.1 HipA N-terminal domain-containing protein Toxin
C7X15_RS12995 2603679..2603945 - 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
C7X15_RS13000 2604253..2605011 + 759 WP_001286540.1 trans-aconitate 2-methyltransferase -
C7X15_RS13005 2605015..2605929 - 915 WP_001443133.1 bestrophin family protein -
C7X15_RS13010 2606126..2607577 - 1452 WP_000854660.1 tagaturonate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - fimA 2587618..2603945 16327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 236 a.a.        Molecular weight: 26661.77 Da        Isoelectric Point: 8.0645

>T100966 WP_135801351.1 NZ_CP028320:c2603679-2602972 [Escherichia coli O18:H1]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKKTA
IDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIPAALDNVKNSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 708 bp

>T100966 NZ_CP028320:c2603679-2602972 [Escherichia coli O18:H1]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGAAAACGGCA
ATCGATAAAATTTATCCGCGACATTTTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCT
GAGTGACTTTGCCAGAATGATTCCGGCAGCACTGGATAACGTGAAGAATTCATTACCGACAGATTTTCCGGAGAACGTGG
TGACGGCAGTTGAAACCAATGTGTTGAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT100966 WP_001304368.1 NZ_CP028320:c2603945-2603679 [Escherichia coli O18:H1]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp

>AT100966 NZ_CP028320:c2603945-2603679 [Escherichia coli O18:H1]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
GCAGAACAGCAAGATTTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References