Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | timP-timR/- |
| Location | 2672473..2672911 | Replicon | |
| Accession | NC_016810 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | ||
| T1TAdb ID | TA07144 | ||
Toxin (Protein)
| Gene name | timP | Uniprot ID | - |
| Locus tag | SL1344_RS27845 | Protein ID | WP_242617172.1 |
| Coordinates | 2672795..2672911 (+) | Length | 39 a.a. |
Antitoxin (RNA)
| Gene name | timR | ||
| Locus tag | - | ||
| Coordinates | 2672473..2672567 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SL1344_RS12985 (SL1344_2495) | 2670622..2671464 | + | 843 | WP_000205241.1 | 3-mercaptopyruvate sulfurtransferase | - |
| SL1344_RS12990 (SL1344_2496) | 2671711..2672379 | + | 669 | WP_000355342.1 | DUF5066 family protein | - |
| - | 2672473..2672567 | - | 95 | - | - | Antitoxin |
| SL1344_RS27845 | 2672795..2672911 | + | 117 | WP_242617172.1 | small toxic inner membrane protein TimP | Toxin |
| SL1344_RS12995 (SL1344_2497) | 2672948..2673724 | - | 777 | WP_001533245.1 | enhanced serine sensitivity protein SseB | - |
| SL1344_RS13000 (SL1344_2498) | 2673834..2675117 | - | 1284 | WP_000133541.1 | aminopeptidase PepB | - |
| SL1344_RS13005 (SL1344_2499) | 2675364..2675564 | - | 201 | WP_000523621.1 | Fe-S cluster assembly protein IscX | - |
| SL1344_RS13010 (SL1344_2500) | 2675576..2675911 | - | 336 | WP_001124466.1 | ISC system 2Fe-2S type ferredoxin | - |
| SL1344_RS13015 (SL1344_2501) | 2675913..2677763 | - | 1851 | WP_001196669.1 | Fe-S protein assembly chaperone HscA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 39 a.a. Molecular weight: 4163.95 Da Isoelectric Point: 8.7978
>T10086 WP_242617172.1 NC_016810:2672795-2672911 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MKVRCFCVVLLVSGTLCLHADRSYPGNSVPVTLNVQSR
MKVRCFCVVLLVSGTLCLHADRSYPGNSVPVTLNVQSR
Download Length: 117 bp
>T10086 NC_016810:2672795-2672911 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGAAGGTACGATGCTTTTGTGTCGTGCTTCTTGTTTCTGGCACGTTGTGTCTTCACGCAGACAGAAGCTACCCAGGTAA
TTCTGTTCCCGTAACGCTCAACGTCCAGAGCAGGTAA
ATGAAGGTACGATGCTTTTGTGTCGTGCTTCTTGTTTCTGGCACGTTGTGTCTTCACGCAGACAGAAGCTACCCAGGTAA
TTCTGTTCCCGTAACGCTCAACGTCCAGAGCAGGTAA
Antitoxin
Download Length: 95 bp
>AT10086 NC_016810:c2672567-2672473 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
CTACGGTGTGCCTGCGTTGCTATGGCAACAAAGCCTGCTGGAAAGGCCGCGAACCGGACCAGCACAAAAAAACCGCTCAA
TTGAGCGGTTTTTTT
CTACGGTGTGCCTGCGTTGCTATGGCAACAAAGCCTGCTGGAAAGGCCGCGAACCGGACCAGCACAAAAAAACCGCTCAA
TTGAGCGGTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10087 | Escherichia coli str. K-12 substr. MG1655 |
48.718 |
100 |
0.5 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Liis Andresen et al. (2020) The Small Toxic Salmonella Protein TimP Targets the Cytoplasmic Membrane and Is Repressed by the Small RNA TimR. MBio 11(6):e01659-20. [PubMed:33172998]