Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/- |
| Location | 2673871..2675338 | Replicon | chromosome |
| Accession | NC_002942 | ||
| Organism | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | Q5ZSZ6 |
| Locus tag | LPG_RS11920 | Protein ID | WP_010948074.1 |
| Coordinates | 2674400..2675338 (+) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | Q5ZSZ7 |
| Locus tag | LPG_RS11915 | Protein ID | WP_010948073.1 |
| Coordinates | 2674095..2674403 (+) | Length | 103 a.a. |
Regulator (Protein)
| Gene name | HipB | Uniprot ID | - |
| Locus tag | LPG_RS11910 | Protein ID | WP_006870829.1 |
| Coordinates | 2673871..2674098 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPG_RS11885 (lpg2364) | 2669531..2669896 | + | 366 | WP_010948069.1 | BRCT domain-containing protein | - |
| LPG_RS11890 (lpg2365) | 2670253..2670618 | - | 366 | WP_010948070.1 | TraK family protein | - |
| LPG_RS11895 | 2670803..2670943 | - | 141 | WP_153802426.1 | hypothetical protein | - |
| LPG_RS11900 (lpg2366) | 2670946..2672697 | - | 1752 | WP_010948071.1 | DUF927 domain-containing protein | - |
| LPG_RS11905 (lpg2367) | 2672763..2673038 | - | 276 | WP_010948072.1 | helix-turn-helix domain-containing protein | - |
| LPG_RS11910 (lpg2368) | 2673871..2674098 | + | 228 | WP_006870829.1 | helix-turn-helix transcriptional regulator | Regulator |
| LPG_RS11915 (lpg2369) | 2674095..2674403 | + | 309 | WP_010948073.1 | HipA N-terminal domain-containing protein | Antitoxin |
| LPG_RS11920 (lpg2370) | 2674400..2675338 | + | 939 | WP_010948074.1 | lpg2370 family Dot/Icm T4SS effector | Toxin |
| LPG_RS11930 (lpg2371) | 2675881..2676495 | + | 615 | WP_010948075.1 | hypothetical protein | - |
| LPG_RS11935 | 2676651..2676857 | - | 207 | WP_015444115.1 | hypothetical protein | - |
| LPG_RS11940 (lpg2372) | 2677194..2678462 | + | 1269 | WP_010948076.1 | lpg2372 family Dot/Icm T4SS effector | - |
| LPG_RS11945 | 2678678..2679203 | - | 526 | Protein_2341 | hypothetical protein | - |
| LPG_RS11950 (lpg2373) | 2679203..2679868 | - | 666 | WP_015444114.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2668117..2669292 | 1175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 36077.81 Da Isoelectric Point: 8.6882
>T10036 WP_010948074.1 NC_002942:2674400-2675338 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD
Download Length: 939 bp
>T10036 NC_002942:2674400-2675338 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
ATGAAACACTGCCCTATTACTTATGAAAAGATTAGTGACCAGGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTGGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTGTTCAAGGCGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAAGGCTGTTTTGAAATCGTGGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGAACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCTTGGTCGGTAATGAAGACATGCATCTAAAAAACTTTTCCTTAATTACGAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAACACAAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGCTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA
ATGAAACACTGCCCTATTACTTATGAAAAGATTAGTGACCAGGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTGGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTGTTCAAGGCGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAAGGCTGTTTTGAAATCGTGGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGAACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCTTGGTCGGTAATGAAGACATGCATCTAAAAAACTTTTCCTTAATTACGAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAACACAAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGCTTCAGTTTTTTATCTCAAGAGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11557.38 Da Isoelectric Point: 4.5994
>AT10036 WP_010948073.1 NC_002942:2674095-2674403 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR
Download Length: 309 bp
>AT10036 NC_002942:2674095-2674403 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
ATGAGAAAAGCATACGTATCGGTGAGTGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGATTTTGACGTGTTCC
CCCCTTTTTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATACAAGATAGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA
ATGAGAAAAGCATACGTATCGGTGAGTGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGATTTTGACGTGTTCC
CCCCTTTTTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATACAAGATAGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA
Regulator
Download Length: 76 a.a. Molecular weight: 8554.85 Da Isoelectric Point: 9.5375
>RE10036 WP_006870829.1 NC_002942:2673871-2674098 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MPKHEIANLIHYYRKQSGLSQQELARLAGVGKTVIYDIEKGKESVRLNTLLKVLDVLNIQIKFETPFPQTTDNNS
MPKHEIANLIHYYRKQSGLSQQELARLAGVGKTVIYDIEKGKESVRLNTLLKVLDVLNIQIKFETPFPQTTDNNS
Download Length: 228 bp
>RE10036 NC_002942:2673871-2674098 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
ATGCCCAAACACGAAATTGCCAATTTAATCCATTATTACCGCAAACAAAGCGGCTTATCACAACAAGAATTAGCCCGGTT
AGCGGGGGTCGGTAAGACGGTCATCTATGATATTGAAAAAGGGAAAGAATCGGTGCGGCTAAATACATTGCTAAAAGTGC
TCGATGTTTTAAATATCCAAATAAAATTTGAAACGCCTTTTCCTCAAACAACGGATAATAATTCATGA
ATGCCCAAACACGAAATTGCCAATTTAATCCATTATTACCGCAAACAAAGCGGCTTATCACAACAAGAATTAGCCCGGTT
AGCGGGGGTCGGTAAGACGGTCATCTATGATATTGAAAAAGGGAAAGAATCGGTGCGGCTAAATACATTGCTAAAAGTGC
TCGATGTTTTAAATATCCAAATAAAATTTGAAACGCCTTTTCCTCAAACAACGGATAATAATTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10121 | Escherichia coli O127:H6 str. E2348/69 |
29.326 |
100 |
0.321 |
| T10106 | Xenorhabdus nematophila ATCC 19061 |
30.097 |
100 |
0.304 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
References
(1) Xiangkai Zhen et al. (2022) Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila. Nature Communications 13(1):4333. [PubMed:35882877]