Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/- |
| Location | 2083169..2084042 | Replicon | chromosome |
| Accession | NZ_CP015625 | ||
| Organism | Bartonella apis strain BBC0122 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | BBC0122_RS09205 | Protein ID | WP_077993242.1 |
| Coordinates | 2083647..2084042 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | BBC0122_RS09200 | Protein ID | WP_077993240.1 |
| Coordinates | 2083169..2083642 (+) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BBC0122_RS09185 (BBC0122_017720) | 2079726..2080583 | - | 858 | WP_077993234.1 | hypothetical protein | - |
| BBC0122_RS09190 (BBC0122_017730) | 2080631..2081383 | - | 753 | WP_077993236.1 | hypothetical protein | - |
| BBC0122_RS09195 (BBC0122_017740) | 2082107..2082937 | + | 831 | WP_149866674.1 | hypothetical protein | - |
| BBC0122_RS09200 (BBC0122_017750) | 2083169..2083642 | + | 474 | WP_077993240.1 | SocA family protein | Antitoxin |
| BBC0122_RS09205 (BBC0122_017760) | 2083647..2084042 | + | 396 | WP_077993242.1 | hypothetical protein | Toxin |
| BBC0122_RS09210 (BBC0122_017770) | 2084192..2085517 | + | 1326 | WP_077993244.1 | phage terminase large subunit | - |
| BBC0122_RS12860 | 2085711..2086007 | + | 297 | WP_149866675.1 | hypothetical protein | - |
| BBC0122_RS09220 (BBC0122_017780) | 2086165..2088261 | + | 2097 | WP_077993248.1 | phage portal protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14901.18 Da Isoelectric Point: 6.4706
>T10009 WP_077993242.1 NZ_CP015625:2083647-2084042 [Bartonella apis]
MGAEDEIKGANKKVPPLREPDVVDDADSLKEAAELSSGLSSTELEKQANEKKFKRRERFKDHFECSLLFFLWGITTLIAV
TTLIWTFHLIAPVSWCWLNKEGIERLQTILFSGVGGVLYTIFSKNIKNRID
MGAEDEIKGANKKVPPLREPDVVDDADSLKEAAELSSGLSSTELEKQANEKKFKRRERFKDHFECSLLFFLWGITTLIAV
TTLIWTFHLIAPVSWCWLNKEGIERLQTILFSGVGGVLYTIFSKNIKNRID
Download Length: 396 bp
>T10009 NZ_CP015625:2083647-2084042 [Bartonella apis]
ATGGGGGCGGAGGACGAAATTAAAGGTGCCAATAAAAAAGTTCCGCCCCTGCGGGAACCTGATGTTGTTGACGACGCGGA
TTCGCTTAAGGAAGCAGCTGAGCTTTCAAGTGGACTTTCTTCGACGGAACTAGAAAAACAAGCTAACGAAAAGAAGTTCA
AGCGACGAGAACGATTTAAAGATCACTTCGAATGTAGCCTCTTATTTTTTTTATGGGGGATTACCACCTTAATTGCAGTT
ACAACATTAATCTGGACATTTCATTTGATCGCTCCTGTTAGTTGGTGTTGGTTAAATAAAGAAGGTATTGAACGTCTTCA
AACGATTCTTTTTAGCGGTGTTGGCGGTGTTTTATATACAATTTTTTCCAAAAATATAAAAAATCGGATAGATTAG
ATGGGGGCGGAGGACGAAATTAAAGGTGCCAATAAAAAAGTTCCGCCCCTGCGGGAACCTGATGTTGTTGACGACGCGGA
TTCGCTTAAGGAAGCAGCTGAGCTTTCAAGTGGACTTTCTTCGACGGAACTAGAAAAACAAGCTAACGAAAAGAAGTTCA
AGCGACGAGAACGATTTAAAGATCACTTCGAATGTAGCCTCTTATTTTTTTTATGGGGGATTACCACCTTAATTGCAGTT
ACAACATTAATCTGGACATTTCATTTGATCGCTCCTGTTAGTTGGTGTTGGTTAAATAAAGAAGGTATTGAACGTCTTCA
AACGATTCTTTTTAGCGGTGTTGGCGGTGTTTTATATACAATTTTTTCCAAAAATATAAAAAATCGGATAGATTAG
Antitoxin
Download Length: 158 a.a. Molecular weight: 18039.35 Da Isoelectric Point: 6.7540
>AT10009 WP_077993240.1 NZ_CP015625:2083169-2083642 [Bartonella apis]
MHDSTVVANCFLKLAKDKNDTLTPMQLLKLVYIAHGWMLGLYGRPLIKDEIQAWQYGPVIPNLYNKIRRYKSNPVTDYID
HGLNNDRADDQLDYDENDIVNQVYQIYGHLSGPYLSRLTHQPGSPWEVTYKPGVFGAVISNDVIEDHYQRRASSKQG
MHDSTVVANCFLKLAKDKNDTLTPMQLLKLVYIAHGWMLGLYGRPLIKDEIQAWQYGPVIPNLYNKIRRYKSNPVTDYID
HGLNNDRADDQLDYDENDIVNQVYQIYGHLSGPYLSRLTHQPGSPWEVTYKPGVFGAVISNDVIEDHYQRRASSKQG
Download Length: 474 bp
>AT10009 NZ_CP015625:2083169-2083642 [Bartonella apis]
ATGCACGATAGCACAGTTGTCGCCAATTGCTTCCTGAAATTAGCTAAGGACAAGAATGATACTTTAACACCCATGCAACT
GTTAAAGTTGGTGTACATCGCACATGGTTGGATGCTTGGATTATACGGTCGACCATTGATTAAAGACGAGATTCAGGCTT
GGCAATACGGCCCCGTCATTCCGAATCTCTATAATAAGATCAGGCGTTACAAAAGTAATCCCGTTACAGATTATATAGAT
CACGGATTAAACAATGATCGCGCTGATGATCAATTAGATTATGACGAAAACGACATTGTTAATCAGGTGTATCAGATATA
TGGACACTTATCGGGGCCTTATCTTTCGCGGTTAACGCATCAACCAGGCTCTCCATGGGAAGTGACATATAAGCCAGGTG
TATTCGGTGCTGTTATATCAAATGATGTCATAGAAGACCATTACCAACGGCGAGCAAGCTCCAAACAAGGTTAA
ATGCACGATAGCACAGTTGTCGCCAATTGCTTCCTGAAATTAGCTAAGGACAAGAATGATACTTTAACACCCATGCAACT
GTTAAAGTTGGTGTACATCGCACATGGTTGGATGCTTGGATTATACGGTCGACCATTGATTAAAGACGAGATTCAGGCTT
GGCAATACGGCCCCGTCATTCCGAATCTCTATAATAAGATCAGGCGTTACAAAAGTAATCCCGTTACAGATTATATAGAT
CACGGATTAAACAATGATCGCGCTGATGATCAATTAGATTATGACGAAAACGACATTGTTAATCAGGTGTATCAGATATA
TGGACACTTATCGGGGCCTTATCTTTCGCGGTTAACGCATCAACCAGGCTCTCCATGGGAAGTGACATATAAGCCAGGTG
TATTCGGTGCTGTTATATCAAATGATGTCATAGAAGACCATTACCAACGGCGAGCAAGCTCCAAACAAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10007 | Escherichia coli STEC_O31 |
38.462 |
99.363 |
0.382 |
| AT10013 | Vibrio harveyi strain FDAARGOS_107 |
36.111 |
92.903 |
0.335 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Tatsuaki Kurata et al. (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of The National Academy of Sciences of The United States of America 119(6):e2102212119. [PubMed:35121656]