MGE detailed information
MGE type: Conjugative plasmid MGE length: 124410 bp
Accession: NZ_CP121156 Location: 1..124410 Organism: Escherichia coli strain E67 Replicon: plasmid pE67-1
Accession: NZ_CP121156 Location: 1..124410 Organism: Escherichia coli strain E67 Replicon: plasmid pE67-1
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P6H85_RS23740 (64) | 64..324 | + | 261 | WP_000083818.1 | replication regulatory protein RepA | - |
| P6H85_RS23745 (350) | 350..586 | - | 237 | WP_223368648.1 | replication protein RepA | - |
| P6H85_RS23750 (577) | 577..624 | + | 48 | WP_077822033.1 | hypothetical protein | - |
| P6H85_RS23755 (617) | 617..1474 | + | 858 | WP_000130940.1 | incFII family plasmid replication initiator RepA | - |
| P6H85_RS23760 (2414) | 2414..3067 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| P6H85_RS23765 (3160) | 3160..3417 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| P6H85_RS23770 (3350) | 3350..3751 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| P6H85_RS23775 (4000) | 4000..4415 | + | 416 | Protein_7 | IS1-like element IS1B family transposase | - |
| P6H85_RS23780 (4451) | 4451..4996 | - | 546 | Protein_8 | Tn3 family transposase TnpA_Tn3 | Transposase |
| P6H85_RS23785 (5062) | 5062..5766 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS23790 (5831) | 5831..6010 | + | 180 | Protein_10 | IS1380 family transposase | - |
| P6H85_RS23795 (6260) | 6260..7135 | + | 876 | WP_032277257.1 | Beta-lactamase CTX-M-97 | ARG |
| P6H85_RS23800 (7170) | 7170..8138 | + | 969 | WP_013362812.1 | IS5 family transposase IS903B | Transposase |
| P6H85_RS23805 (8195) | 8195..9292 | + | 1098 | Protein_13 | TonB-dependent receptor | - |
| P6H85_RS23810 (9360) | 9360..9749 | - | 390 | Protein_14 | Tn3 family transposase TnpA_Tn3 | Transposase |
| P6H85_RS23815 (9913) | 9913..10470 | + | 558 | WP_001235713.1 | Tn3 family transposase TnpR_Tn3 | Transposase |
| P6H85_RS23820 (10653) | 10653..11066 | + | 414 | Protein_16 | serine hydrolase | - |
| P6H85_RS23825 (11129) | 11129..11833 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS23830 (12032) | 12032..12382 | - | 351 | WP_000454193.1 | DUF3330 domain-containing protein | - |
| P6H85_RS23835 (12585) | 12585..13598 | - | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| P6H85_RS23840 (13765) | 13765..14607 | + | 843 | WP_001456218.1 | alpha/beta fold putative hydrolase EstX | - |
| P6H85_RS23845 (14703) | 14703..15311 | + | 609 | WP_000050382.1 | HAD family hydrolase | - |
| P6H85_RS23850 (15369) | 15369..16207 | + | 839 | Protein_22 | Streptomycin 3''-adenylyltransferase | ARG |
| P6H85_RS23855 (16422) | 16422..17681 | + | 1260 | WP_000095725.1 | chloramphenicol efflux MFS transporter CmlA1 | ARG |
| P6H85_RS23860 (17774) | 17774..18612 | + | 839 | Protein_24 | Streptomycin 3''-adenylyltransferase | ARG |
| P6H85_RS23865 (18735) | 18735..19067 | + | 333 | WP_000800531.1 | quaternary ammonium compound efflux SMR transporter QacL | - |
| P6H85_RS23870 (19314) | 19314..19946 | - | 633 | WP_020802982.1 | IS256 family transposase | - |
| P6H85_RS23875 (19969) | 19969..20244 | + | 276 | WP_109023896.1 | hypothetical protein | - |
| P6H85_RS23880 (20247) | 20247..21038 | - | 792 | WP_000034420.1 | Dihydropteroate synthase | ARG |
| P6H85_RS23885 (21507) | 21507..21752 | - | 246 | WP_001354008.1 | GrpB family protein | - |
| P6H85_RS23890 (21790) | 21790..22653 | - | 864 | WP_000612791.1 | SDR family oxidoreductase | - |
| P6H85_RS23895 (22799) | 22799..22867 | - | 69 | Protein_31 | macrolide transporter | - |
| P6H85_RS23900 (22914) | 22914..23618 | - | 705 | WP_001067834.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS23905 (23769) | 23769..24584 | + | 816 | WP_000018329.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| P6H85_RS23910 (24774) | 24774..24881 | - | 108 | Protein_34 | IS6 family transposase | - |
| P6H85_RS23915 (24938) | 24938..25642 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS23920 (25597) | 25597..27273 | - | 1677 | Protein_36 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| P6H85_RS23925 (27277) | 27277..27669 | + | 393 | WP_001351729.1 | isochorismatase family cysteine hydrolase | - |
| P6H85_RS23930 (27807) | 27807..28691 | + | 885 | WP_000058717.1 | EamA family transporter | - |
| P6H85_RS23935 (28723) | 28723..29922 | - | 1200 | WP_000804064.1 | Tetracycline resistance protein, class C | ARG |
| P6H85_RS23940 (30028) | 30028..30678 | + | 651 | WP_000164043.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| P6H85_RS23945 (30710) | 30710..30952 | - | 243 | WP_000844627.1 | transposase | - |
| P6H85_RS23950 (31010) | 31010..32524 | - | 1515 | Protein_42 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| P6H85_RS23955 (32590) | 32590..33294 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS23960 (33347) | 33347..33667 | - | 321 | Protein_44 | NAD(P)H-dependent oxidoreductase | - |
| P6H85_RS23965 (33828) | 33828..34151 | - | 324 | WP_001175594.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| P6H85_RS23970 (34256) | 34256..35335 | + | 1080 | WP_001089727.1 | permease | - |
| P6H85_RS23975 (35628) | 35628..36245 | - | 618 | WP_000521603.1 | ProQ/FINO family protein | - |
| P6H85_RS23980 (36437) | 36437..37993 | - | 1557 | WP_000818556.1 | AAA family ATPase | - |
| P6H85_RS23985 (38256) | 38256..38846 | - | 591 | WP_000194575.1 | hypothetical protein | - |
| P6H85_RS23990 (38846) | 38846..39103 | - | 258 | WP_000343085.1 | hypothetical protein | - |
| P6H85_RS23995 (39457) | 39457..41595 | + | 2139 | WP_000350638.1 | AAA family ATPase | - |
| P6H85_RS24000 (41757) | 41757..42173 | - | 417 | WP_001044768.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| P6H85_RS24005 (42170) | 42170..42400 | - | 231 | WP_001261287.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin Detail |
| P6H85_RS24010 (42696) | 42696..42986 | + | 291 | WP_000111771.1 | hypothetical protein | - |
| P6H85_RS24015 (42976) | 42976..43875 | + | 900 | WP_000963206.1 | nucleotide-binding protein | - |
| P6H85_RS24020 (43925) | 43925..46150 | - | 2226 | WP_000698737.1 | P-loop NTPase fold protein | - |
| P6H85_RS24025 (46152) | 46152..47240 | - | 1089 | WP_000952217.1 | transcriptional repressor PifC | - |
| P6H85_RS24030 (47785) | 47785..48135 | + | 351 | WP_000493379.1 | hypothetical protein | - |
| P6H85_RS24035 (48179) | 48179..48868 | + | 690 | WP_000796228.1 | hypothetical protein | - |
| P6H85_RS24040 (48865) | 48865..49656 | + | 792 | WP_000016493.1 | site-specific integrase | - |
| P6H85_RS24050 (50472) | 50472..50740 | + | 269 | Protein_62 | IS3 family transposase ISLad1 | Transposase |
| P6H85_RS24060 (52240) | 52240..52419 | + | 180 | Protein_64 | integrase core domain-containing protein | - |
| P6H85_RS24065 (53716) | 53716..54669 | + | 954 | WP_000280980.1 | Protease 7 | VF |
| P6H85_RS24070 (55102) | 55102..56211 | + | 1110 | WP_000771475.1 | SDR family oxidoreductase | - |
| P6H85_RS24075 (56280) | 56280..57182 | + | 903 | WP_001312822.1 | hypothetical protein | VF |
| P6H85_RS24080 (57556) | 57556..57744 | + | 189 | WP_014640565.1 | hypothetical protein | - |
| P6H85_RS24085 (57865) | 57865..58605 | + | 741 | WP_001066954.1 | tyrosine-type recombinase/integrase | - |
| P6H85_RS24090 (58890) | 58890..59867 | - | 978 | WP_000361611.1 | RepB family plasmid replication initiator protein | - |
| P6H85_RS24100 (61874) | 61874..62068 | + | 195 | Protein_72 | IS21 family transposase IS21 | Transposase |
| P6H85_RS24105 (62125) | 62125..62822 | + | 698 | WP_095033700.1 | IS1 family transposase IS1R | Transposase |
| P6H85_RS24110 (63122) | 63122..64288 | + | 1167 | WP_001238646.1 | hypothetical protein | VF |
| P6H85_RS24115 (64288) | 64288..65259 | + | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| P6H85_RS24120 (65896) | 65896..66065 | + | 170 | Protein_76 | hypothetical protein | - |
| P6H85_RS24125 (66062) | 66062..66409 | + | 348 | WP_001350917.1 | hypothetical protein | - |
| P6H85_RS24130 (66478) | 66478..66813 | + | 336 | WP_000343070.1 | hypothetical protein | - |
| P6H85_RS24135 (66864) | 66864..67561 | + | 698 | WP_095033700.1 | IS1 family transposase IS1R | Transposase |
| P6H85_RS24140 (67614) | 67614..68585 | - | 972 | WP_000082154.1 | IS110 family transposase ISEc32 | Transposase |
| P6H85_RS24145 (68987) | 68987..69412 | + | 426 | WP_001198922.1 | antirestriction protein | - |
| P6H85_RS24150 (69412) | 69412..69873 | + | 462 | WP_042007484.1 | DUF1380 family protein | - |
| P6H85_RS24155 (69873) | 69873..70055 | + | 183 | WP_001027505.1 | hypothetical protein | - |
| P6H85_RS24160 (70279) | 70279..70532 | - | 254 | Protein_84 | hypothetical protein | - |
| P6H85_RS24165 (71049) | 71049..71279 | + | 231 | WP_000218642.1 | hypothetical protein | - |
| P6H85_RS24170 (71331) | 71331..72692 | + | 1362 | WP_000170681.1 | DUF3560 domain-containing protein | - |
| P6H85_RS24175 (72738) | 72738..73301 | + | 564 | WP_001311069.1 | class I SAM-dependent methyltransferase | - |
| P6H85_RS24180 (73301) | 73301..73543 | + | 243 | WP_001610271.1 | hypothetical protein | - |
| P6H85_RS24185 (73453) | 73453..73713 | + | 261 | WP_072132736.1 | hypothetical protein | - |
| P6H85_RS24190 (74186) | 74186..74713 | + | 528 | WP_000290793.1 | single-stranded DNA-binding protein | - |
| P6H85_RS24195 (74769) | 74769..75002 | + | 234 | WP_000006004.1 | DUF905 domain-containing protein | - |
| P6H85_RS24200 (75061) | 75061..77019 | + | 1959 | WP_001145469.1 | ParB/RepB/Spo0J family partition protein | - |
| P6H85_RS24205 (77074) | 77074..77508 | + | 435 | WP_000845895.1 | conjugation system SOS inhibitor PsiB | - |
| P6H85_RS24210 (77505) | 77505..78267 | + | 763 | Protein_94 | plasmid SOS inhibition protein A | - |
| P6H85_RS24215 (78236) | 78236..78424 | - | 189 | WP_001299721.1 | hypothetical protein | - |
| - (78236) | 78236..78433 | + | 198 | NuclAT_0 | - | - |
| - (78236) | 78236..78433 | + | 198 | NuclAT_0 | - | - |
| - (78236) | 78236..78433 | + | 198 | NuclAT_0 | - | - |
| - (78236) | 78236..78433 | + | 198 | NuclAT_0 | - | - |
| P6H85_RS24220 (78481) | 78481..79850 | + | 1370 | WP_087522250.1 | IS3-like element IS150 family transposase | - |
| - (79875) | 79875..79906 | + | 32 | NuclAT_1 | - | Antitoxin Detail |
| - (79875) | 79875..79906 | + | 32 | NuclAT_1 | - | Antitoxin Detail |
| - (79875) | 79875..79906 | + | 32 | NuclAT_1 | - | Antitoxin Detail |
| - (79875) | 79875..79906 | + | 32 | NuclAT_1 | - | Antitoxin Detail |
| P6H85_RS24225 (79892) | 79892..80041 | + | 150 | Protein_97 | plasmid maintenance protein Mok | - |
| P6H85_RS24230 (79983) | 79983..80108 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| P6H85_RS24235 (80328) | 80328..80558 | + | 231 | WP_001426396.1 | hypothetical protein | - |
| P6H85_RS24240 (80556) | 80556..80729 | - | 174 | Protein_100 | hypothetical protein | - |
| P6H85_RS24245 (80799) | 80799..81005 | + | 207 | WP_000547939.1 | hypothetical protein | - |
| P6H85_RS24250 (81030) | 81030..81317 | + | 288 | WP_000107535.1 | hypothetical protein | - |
| P6H85_RS24255 (81438) | 81438..82259 | + | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| P6H85_RS24260 (82556) | 82556..83203 | - | 648 | WP_000614936.1 | hypothetical protein | VF |
| P6H85_RS24265 (83480) | 83480..83863 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| P6H85_RS24270 (84054) | 84054..84740 | + | 687 | WP_000332484.1 | PAS domain-containing protein | - |
| P6H85_RS24275 (84834) | 84834..85061 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
| P6H85_RS24280 (85095) | 85095..85454 | + | 360 | WP_000340272.1 | type IV conjugative transfer system pilin TraA | - |
| P6H85_RS24285 (85469) | 85469..85780 | + | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| P6H85_RS24290 (85802) | 85802..86368 | + | 567 | WP_000399792.1 | type IV conjugative transfer system protein TraE | - |
| P6H85_RS24295 (86355) | 86355..87083 | + | 729 | WP_001230787.1 | type-F conjugative transfer system secretin TraK | - |
| P6H85_RS24300 (87083) | 87083..88510 | + | 1428 | WP_000146685.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| P6H85_RS24305 (88500) | 88500..89072 | + | 573 | WP_000002780.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| P6H85_RS24310 (89069) | 89069..89386 | + | 318 | WP_001057292.1 | conjugal transfer protein TrbD | - |
| P6H85_RS24315 (89383) | 89383..89634 | + | 252 | WP_001038341.1 | conjugal transfer protein TrbG | - |
| P6H85_RS24320 (89631) | 89631..90146 | + | 516 | WP_000809906.1 | type IV conjugative transfer system lipoprotein TraV | - |
| P6H85_RS24325 (90281) | 90281..90502 | + | 222 | WP_001278689.1 | conjugal transfer protein TraR | - |
| P6H85_RS24330 (90662) | 90662..93289 | + | 2628 | WP_001064268.1 | type IV secretion system protein TraC | - |
| P6H85_RS24335 (93286) | 93286..93672 | + | 387 | WP_000214084.1 | type-F conjugative transfer system protein TrbI | - |
| P6H85_RS24340 (93669) | 93669..94301 | + | 633 | WP_001203745.1 | type-F conjugative transfer system protein TraW | - |
| P6H85_RS24345 (94298) | 94298..95290 | + | 993 | WP_000830839.1 | conjugal transfer pilus assembly protein TraU | - |
| P6H85_RS24350 (95316) | 95316..95777 | + | 462 | WP_000277845.1 | hypothetical protein | - |
| P6H85_RS24355 (95807) | 95807..96259 | + | 453 | WP_000069427.1 | hypothetical protein | - |
| P6H85_RS24360 (96287) | 96287..96925 | + | 639 | WP_001104248.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| P6H85_RS24365 (96922) | 96922..97782 | + | 861 | Protein_125 | conjugal transfer protein TraN | - |
| P6H85_RS24370 (97842) | 97842..98546 | + | 705 | WP_208789585.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS24375 (98598) | 98598..99107 | + | 510 | Protein_127 | IS6 family transposase IS6100 | Transposase |
| P6H85_RS24380 (99600) | 99600..100184 | - | 585 | WP_001137892.1 | macrolide-binding transcriptional repressor MphR(A) | - |
| P6H85_RS24385 (100184) | 100184..101422 | - | 1239 | WP_000004159.1 | macrolide resistance MFS transporter Mrx(A) | - |
| P6H85_RS24390 (101419) | 101419..102324 | - | 906 | WP_000219391.1 | hypothetical protein | ARG |
| P6H85_RS24395 (102446) | 102446..103150 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS24400 (103201) | 103201..103761 | + | 561 | WP_021532377.1 | Tn3 family transposase TnpR_TnAs3 | Transposase |
| P6H85_RS24405 (103764) | 103764..106730 | + | 2967 | WP_001138064.1 | Tn3 family transposase TnpA_TnAs3 | Transposase |
| P6H85_RS24410 (106809) | 106809..107813 | + | 1005 | WP_000427619.1 | IS110 family transposase IS5075 | Transposase |
| P6H85_RS24415 (108032) | 108032..108670 | - | 639 | WP_061093065.1 | hypothetical protein | - |
| P6H85_RS24420 (108670) | 108670..108924 | - | 255 | WP_000343103.1 | hypothetical protein | - |
| P6H85_RS24425 (109276) | 109276..110277 | + | 1002 | WP_000774874.1 | DUF4238 domain-containing protein | - |
| P6H85_RS24430 (110453) | 110453..110797 | - | 345 | WP_000793307.1 | hypothetical protein | - |
| P6H85_RS24435 (111383) | 111383..112087 | + | 705 | WP_001067834.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS24440 (112535) | 112535..113548 | - | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| P6H85_RS24445 (113704) | 113704..114177 | + | 474 | WP_004201280.1 | Dihydrofolate reductase type 1 | ARG |
| P6H85_RS24450 (114247) | 114247..114951 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS24455 (115005) | 115005..115319 | + | 315 | Protein_143 | Tn3 family transposase TnpR_TnAs3 | Transposase |
| P6H85_RS24460 (115322) | 115322..118288 | + | 2967 | WP_001138070.1 | Tn3 family transposase TnpA_ISPa38 | Transposase |
| P6H85_RS24465 (118367) | 118367..119143 | + | 777 | Protein_145 | IS110 family transposase IS5075 | Transposase |
| P6H85_RS24470 (119200) | 119200..119487 | - | 288 | WP_262411635.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS24475 (119478) | 119478..120182 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| P6H85_RS24480 (120236) | 120236..120934 | + | 699 | Protein_148 | Multifunctional conjugation protein TraI | Relaxase |
| P6H85_RS24485 (120954) | 120954..121700 | + | 747 | WP_000205777.1 | conjugal transfer pilus acetylase TraX | - |
| P6H85_RS24490 (121755) | 121755..122315 | + | 561 | WP_000139359.1 | fertility inhibition protein FinO | - |
| P6H85_RS24495 (122453) | 122453..122665 | + | 213 | WP_012311405.1 | hypothetical protein | - |
| P6H85_RS24500 (122908) | 122908..123369 | + | 462 | WP_001233871.1 | thermonuclease family protein | - |
| P6H85_RS24505 (123415) | 123415..123624 | + | 210 | WP_001333231.1 | hemolysin expression modulator Hha | - |
| P6H85_RS24510 (123662) | 123662..124235 | + | 574 | Protein_154 | DUF2726 domain-containing protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|