MGE detailed information
MGE type: Non-Mobilizable plasmid MGE length: 99713 bp
Accession: NZ_CP104852 Location: 1..99713 Organism: Escherichia coli strain GYX208DH4E-2 Replicon: plasmid pHN4E2-NDM5
Accession: NZ_CP104852 Location: 1..99713 Organism: Escherichia coli strain GYX208DH4E-2 Replicon: plasmid pHN4E2-NDM5
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N6H16_RS23465 (1) | 1..978 | + | 978 | WP_000361610.1 | RepB family plasmid replication initiator protein | - |
| N6H16_RS23470 (1263) | 1263..2003 | - | 741 | WP_001066942.1 | tyrosine-type recombinase/integrase | - |
| N6H16_RS23475 (2124) | 2124..2306 | - | 183 | WP_042065278.1 | hypothetical protein | - |
| N6H16_RS23480 (2373) | 2373..2662 | - | 290 | Protein_3 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| N6H16_RS23485 (2649) | 2649..2917 | - | 269 | Protein_4 | type II toxin-antitoxin system ParD family antitoxin | - |
| N6H16_RS23490 (3449) | 3449..4321 | + | 873 | WP_104989445.1 | hypothetical protein | - |
| N6H16_RS23495 (4355) | 4355..5052 | + | 698 | WP_095033700.1 | IS1 family transposase IS1R | Transposase |
| N6H16_RS23500 (5068) | 5068..5187 | + | 120 | Protein_7 | transcriptional regulator | - |
| N6H16_RS23505 (5165) | 5165..5788 | - | 624 | WP_000088605.1 | Tetracycline repressor protein class B from transposon Tn10 | VF |
| N6H16_RS23510 (5870) | 5870..7075 | + | 1206 | WP_001089068.1 | Tetracycline resistance protein, class B | ARG |
| N6H16_RS23515 (7188) | 7188..7781 | - | 594 | WP_000428546.1 | tetracyline resistance-associated transcriptional repressor TetC | - |
| N6H16_RS23520 (7915) | 7915..8619 | + | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| N6H16_RS23525 (8673) | 8673..9038 | - | 366 | Protein_12 | chromate transporter | - |
| N6H16_RS23530 (9194) | 9194..9397 | - | 204 | WP_000376616.1 | hypothetical protein | - |
| N6H16_RS23535 (9525) | 9525..10364 | - | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| N6H16_RS23540 (10358) | 10358..10705 | - | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| N6H16_RS23545 (10822) | 10822..11660 | - | 839 | Protein_16 | Streptomycin 3''-adenylyltransferase | ARG |
| N6H16_RS23550 (11666) | 11666..11956 | - | 291 | WP_001336345.1 | DUF1010 domain-containing protein | - |
| N6H16_RS23555 (12068) | 12068..12565 | - | 498 | WP_001083725.1 | IS1595 family transposase ISSsu9 | ARG |
| N6H16_RS23560 (12710) | 12710..13723 | + | 1014 | WP_000845039.1 | IS91 family transposase ISAzo26 | Transposase |
| N6H16_RS23565 (13926) | 13926..14234 | + | 309 | Protein_20 | EAL domain-containing protein | - |
| N6H16_RS23570 (14125) | 14125..14829 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| N6H16_RS23575 (14994) | 14994..15287 | + | 294 | Protein_22 | IS30 family transposase | - |
| N6H16_RS23580 (15388) | 15388..16200 | + | 813 | WP_023408309.1 | Metallo-beta-lactamase type 2 | ARG |
| N6H16_RS23585 (16204) | 16204..16569 | + | 366 | WP_004201167.1 | bleomycin binding protein Ble-MBL | - |
| N6H16_RS23590 (16574) | 16574..17212 | + | 639 | WP_004201168.1 | phosphoribosylanthranilate isomerase | - |
| N6H16_RS23595 (17223) | 17223..17780 | - | 558 | Protein_26 | twin-arginine translocation (TAT) pathway signal sequence domain protein | - |
| N6H16_RS23600 (17880) | 17880..18254 | - | 375 | Protein_27 | protein-disulfide reductase DsbD family protein | - |
| N6H16_RS23605 (18567) | 18567..20108 | - | 1542 | WP_000050481.1 | IS91 family transposase ISVsa3 | Transposase |
| N6H16_RS23610 (20513) | 20513..21352 | - | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| N6H16_RS23615 (21346) | 21346..21693 | - | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| N6H16_RS23620 (21899) | 21899..22687 | - | 789 | WP_000503573.1 | Streptomycin 3''-adenylyltransferase | ARG |
| N6H16_RS23625 (22818) | 22818..23291 | - | 474 | WP_001389366.1 | trimethoprim-resistant dihydrofolate reductase DfrA17 | - |
| N6H16_RS23630 (23449) | 23449..24462 | + | 1014 | WP_000845048.1 | IS91 family transposase ISAzo26 | Transposase |
| N6H16_RS23635 (24665) | 24665..24973 | + | 309 | Protein_34 | EAL domain-containing protein | - |
| N6H16_RS23640 (24864) | 24864..25568 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| N6H16_RS23645 (25727) | 25727..26008 | - | 282 | Protein_36 | IS91 family transposase ISPps1 | Transposase |
| N6H16_RS23650 (26155) | 26155..27015 | - | 861 | WP_000027057.1 | Beta-lactamase TEM | ARG |
| N6H16_RS23655 (27198) | 27198..27389 | - | 192 | Protein_38 | helix-turn-helix domain-containing protein | - |
| N6H16_RS23660 (27453) | 27453..28157 | + | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| N6H16_RS23665 (28212) | 28212..29057 | - | 846 | Protein_40 | IS4 family transposase IS10R | Transposase |
| N6H16_RS23670 (29167) | 29167..30129 | - | 963 | Protein_41 | IS4 family transposase IS10R | Transposase |
| N6H16_RS23675 (30272) | 30272..31132 | + | 861 | WP_000557454.1 | SPbeta prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD | ARG |
| N6H16_RS23680 (31145) | 31145..31687 | + | 543 | WP_000587837.1 | AAA family ATPase | - |
| N6H16_RS23685 (32169) | 32169..32360 | - | 192 | WP_000951934.1 | hypothetical protein | - |
| N6H16_RS23690 (32384) | 32384..32611 | + | 228 | WP_000248278.1 | hypothetical protein | - |
| N6H16_RS23695 (32662) | 32662..33789 | + | 1128 | WP_014837927.1 | DUF3883 domain-containing protein | - |
| N6H16_RS23700 (33826) | 33826..34530 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| N6H16_RS23705 (34652) | 34652..35566 | + | 915 | WP_023063803.1 | hypothetical protein | ARG |
| N6H16_RS23710 (35563) | 35563..36801 | + | 1239 | WP_000004159.1 | macrolide resistance MFS transporter Mrx(A) | - |
| N6H16_RS23715 (36801) | 36801..37385 | + | 585 | WP_001137892.1 | macrolide-binding transcriptional repressor MphR(A) | - |
| N6H16_RS23720 (37878) | 37878..38642 | - | 765 | WP_001389365.1 | IS6 family transposase IS6100 | Transposase |
| N6H16_RS23725 (38782) | 38782..39486 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| N6H16_RS23730 (39547) | 39547..40383 | - | 837 | WP_000480968.1 | hypothetical protein | ARG |
| N6H16_RS23735 (40383) | 40383..41186 | - | 804 | WP_001082319.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| N6H16_RS23740 (41247) | 41247..42062 | - | 816 | WP_001043265.1 | Dihydropteroate synthase | ARG |
| N6H16_RS23745 (42370) | 42370..43221 | - | 852 | WP_000240536.1 | replication protein C, IncQ-type | - |
| N6H16_RS23750 (43208) | 43208..43927 | - | 720 | Protein_57 | helicase RepA family protein | - |
| N6H16_RS23755 (43977) | 43977..44681 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| N6H16_RS23760 (44746) | 44746..44952 | + | 207 | Protein_59 | serine hydrolase | - |
| N6H16_RS23765 (44999) | 44999..45292 | - | 294 | WP_116961751.1 | WbuC family cupin fold metalloprotein | - |
| N6H16_RS23770 (45357) | 45357..47576 | + | 2220 | Protein_61 | Tn3 family transposase TnpA_Tn3 | Transposase |
| N6H16_RS23775 (47653) | 47653..48357 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| N6H16_RS23780 (48411) | 48411..48851 | - | 441 | Protein_63 | CatB-related O-acetyltransferase | - |
| N6H16_RS23785 (48989) | 48989..49819 | - | 831 | WP_001334766.1 | Beta-lactamase OXA-1 | ARG |
| N6H16_RS23790 (49950) | 49950..50504 | - | 555 | WP_063840321.1 | Aminoglycoside N(6')-acetyltransferase type 1 | ARG |
| N6H16_RS23795 (50648) | 50648..51352 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| N6H16_RS23800 (51424) | 51424..53760 | + | 2337 | Protein_67 | Tn3 family transposase TnpA_Tn5403 | Transposase |
| N6H16_RS23805 (53897) | 53897..54298 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| N6H16_RS23810 (54231) | 54231..54488 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| N6H16_RS23815 (54581) | 54581..55234 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| N6H16_RS23820 (56174) | 56174..57031 | - | 858 | WP_000130640.1 | incFII family plasmid replication initiator RepA | - |
| N6H16_RS23825 (57024) | 57024..57098 | - | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| N6H16_RS23830 (57460) | 57460..59001 | + | 1542 | WP_001298859.1 | IS21 family transposase ISEc12 | Transposase |
| N6H16_RS23835 (59016) | 59016..59762 | + | 747 | WP_053906593.1 | IS21 family transposase ISEc12 | Transposase |
| N6H16_RS23840 (59922) | 59922..60176 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| N6H16_RS23845 (60473) | 60473..60607 | - | 135 | WP_023144756.1 | Hok/Gef family protein | Toxin Detail |
| - (60652) | 60652..60712 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| - (60652) | 60652..60712 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| - (60652) | 60652..60712 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| - (60652) | 60652..60712 | + | 61 | NuclAT_0 | - | Antitoxin Detail |
| N6H16_RS23850 (60679) | 60679..60965 | - | 287 | Protein_77 | DUF2726 domain-containing protein | - |
| N6H16_RS23855 (61478) | 61478..61690 | - | 213 | WP_013023861.1 | hypothetical protein | - |
| N6H16_RS23860 (61821) | 61821..62381 | - | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| N6H16_RS23865 (62436) | 62436..63182 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
| N6H16_RS23870 (63202) | 63202..65024 | - | 1823 | Protein_81 | conjugative transfer relaxase/helicase TraI | - |
| N6H16_RS23875 (65018) | 65018..66076 | - | 1059 | Protein_82 | DUF3560 domain-containing protein | - |
| N6H16_RS23880 (66128) | 66128..66358 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| N6H16_RS23885 (67393) | 67393..67584 | - | 192 | WP_001027516.1 | hypothetical protein | - |
| N6H16_RS23890 (67581) | 67581..68002 | - | 422 | Protein_85 | DUF1380 family protein | - |
| N6H16_RS23895 (68049) | 68049..68474 | - | 426 | WP_001198928.1 | antirestriction protein | - |
| N6H16_RS23900 (68891) | 68891..69667 | - | 777 | WP_001753849.1 | hypothetical protein | - |
| N6H16_RS23905 (69718) | 69718..70236 | - | 519 | WP_123325260.1 | DUF1380 family protein | - |
| N6H16_RS23910 (70166) | 70166..70387 | - | 222 | WP_001104873.1 | hypothetical protein | - |
| N6H16_RS23915 (70388) | 70388..71071 | - | 684 | WP_000086185.1 | DNA methylase | - |
| N6H16_RS23920 (71148) | 71148..71459 | - | 312 | WP_011254640.1 | hypothetical protein | - |
| N6H16_RS23925 (71456) | 71456..72358 | - | 903 | WP_001348615.1 | DUF1281 domain-containing protein | - |
| N6H16_RS23930 (73225) | 73225..74196 | - | 972 | WP_000817036.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| N6H16_RS23935 (74196) | 74196..75362 | - | 1167 | WP_000772446.1 | hypothetical protein | VF |
| N6H16_RS23940 (75950) | 75950..76705 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| N6H16_RS23945 (77479) | 77479..78285 | - | 807 | WP_000016982.1 | site-specific integrase | - |
| N6H16_RS23950 (78286) | 78286..78591 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| N6H16_RS23955 (78593) | 78593..78811 | - | 219 | WP_023909027.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| N6H16_RS23960 (79445) | 79445..79642 | + | 198 | WP_000215657.1 | hypothetical protein | - |
| N6H16_RS23965 (79639) | 79639..79923 | - | 285 | WP_000642771.1 | hypothetical protein | - |
| N6H16_RS23970 (79943) | 79943..81076 | - | 1134 | WP_000545983.1 | DUF3800 domain-containing protein | - |
| N6H16_RS23975 (81339) | 81339..84458 | - | 3120 | WP_023909028.1 | hypothetical protein | - |
| N6H16_RS23980 (84765) | 84765..84995 | + | 231 | WP_001261287.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin Detail |
| N6H16_RS23985 (84992) | 84992..85408 | + | 417 | WP_001044768.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| N6H16_RS23990 (85570) | 85570..87708 | - | 2139 | WP_000350635.1 | AAA family ATPase | - |
| N6H16_RS23995 (88173) | 88173..89168 | + | 996 | WP_000246636.1 | hypothetical protein | - |
| N6H16_RS24000 (89211) | 89211..90104 | + | 894 | WP_001553853.1 | S-4TM family putative pore-forming effector | - |
| N6H16_RS24010 (91152) | 91152..94268 | - | 3117 | WP_031311986.1 | HsdR family type I site-specific deoxyribonuclease | - |
| N6H16_RS24015 (94390) | 94390..95673 | - | 1284 | WP_001617890.1 | restriction endonuclease subunit S | - |
| N6H16_RS24020 (95670) | 95670..97226 | - | 1557 | WP_001553856.1 | type I restriction-modification system subunit M | - |
| N6H16_RS24025 (97409) | 97409..97630 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| N6H16_RS24030 (97630) | 97630..98010 | + | 381 | WP_001216034.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| N6H16_RS24035 (98015) | 98015..98194 | + | 180 | WP_001513661.1 | hypothetical protein | - |
| N6H16_RS24040 (98222) | 98222..98500 | + | 279 | Protein_115 | pdcB | - |
| N6H16_RS24045 (98505) | 98505..98918 | + | 414 | Protein_116 | IS3 family transposase ISLad1 | Transposase |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|