NZ_CP1023921..135425

MGE detailed information

MGE type: Mobilizable plasmid        MGE length: 135425 bp
Accession: NZ_CP102392        Location: 1..135425         Organism: Klebsiella pneumoniae strain K64       Replicon: plasmid pKPC-ESBL-2


Gene structure


The 5 kb flanking regions of this MGE are displayed.

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRF21_RS27530 (1) 1..858 + 858 WP_032495102.1 incFII family plasmid replication initiator RepA -
NRF21_RS27535 (1797) 1797..2450 + 654 WP_000616807.1 CPBP family intramembrane metalloprotease -
NRF21_RS27540 (2543) 2543..2800 + 258 WP_000557619.1 type II toxin-antitoxin system antitoxin PemI -
NRF21_RS27545 (2733) 2733..3134 + 402 WP_001398199.1 type II toxin-antitoxin system toxin endoribonuclease PemK -
NRF21_RS27550 (3383) 3383..3798 + 416 Protein_4 IS1 family transposase -
NRF21_RS27555 (3834) 3834..4379 - 546 Protein_5 Tn3 family transposase TnpA_Tn3 Transposase
NRF21_RS27560 (4445) 4445..5149 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27565 (5219) 5219..5410 + 192 Protein_7 IS1380 family transposase -
NRF21_RS27570 (5660) 5660..6535 + 876 WP_013188475.1 Beta-lactamase Toho-1 ARG
NRF21_RS27575 (6570) 6570..7538 + 969 WP_013362812.1 IS5 family transposase IS903B Transposase
NRF21_RS27580 (7595) 7595..8692 + 1098 Protein_10 TonB-dependent receptor -
NRF21_RS27585 (8760) 8760..9236 - 477 Protein_11 PAS domain-containing protein -
NRF21_RS27590 (9289) 9289..9993 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27595 (10058) 10058..10648 + 591 Protein_13 IS91 family transposase ISSbo1 Transposase
NRF21_RS27600 (11104) 11104..11808 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27605 (11859) 11859..12476 - 618 Protein_15 IS91 family transposase ISSbo1 Transposase
NRF21_RS27610 (12486) 12486..12674 - 189 WP_000957857.1 hypothetical protein -
NRF21_RS27615 (12766) 12766..13302 + 537 WP_064441864.1 Tn3 family transposase TnpR_Tn3 Transposase
NRF21_RS27620 (13485) 13485..14345 + 861 WP_000027057.1 Beta-lactamase TEM ARG
NRF21_RS27625 (14515) 14515..15270 + 756 WP_012372818.1 16S rRNA (guanine(1405)-N(7))-methyltransferase ARG
NRF21_RS27630 (15351) 15351..15665 - 315 Protein_20 hypothetical protein -
NRF21_RS27635 (15720) 15720..16424 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27640 (16517) 16517..17077 + 561 WP_001161490.1 Tn3 family transposase TnpR_TnAs1 Transposase
NRF21_RS27645 (17081) 17081..20047 + 2967 WP_001138014.1 Tn3 family transposase TnpA_TnAs1 Transposase
NRF21_RS27650 (20083) 20083..20151 - 69 Protein_24 IS6 family transposase -
NRF21_RS27655 (20288) 20288..21148 + 861 WP_002904004.1 Beta-lactamase SHV-2 ARG
NRF21_RS27660 (21169) 21169..21930 - 762 WP_002210513.1 DeoR/GlpR family DNA-binding transcription regulator -
NRF21_RS27665 (22192) 22192..23094 + 903 WP_002903955.1 NAD(P)-dependent oxidoreductase -
NRF21_RS27670 (23106) 23106..24358 + 1253 Protein_28 four-carbon acid sugar kinase family protein -
NRF21_RS27675 (24351) 24351..24674 + 324 Protein_29 class II aldolase/adducin family protein -
NRF21_RS27680 (24728) 24728..25432 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27685 (25713) 25713..26096 - 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
NRF21_RS27690 (26373) 26373..27020 + 648 WP_015059008.1 hypothetical protein VF
NRF21_RS27695 (27317) 27317..28138 - 822 WP_001234445.1 DUF932 domain-containing protein -
NRF21_RS27700 (28249) 28249..28545 - 297 WP_001272251.1 hypothetical protein -
NRF21_RS27705 (28845) 28845..29141 + 297 Protein_35 hypothetical protein -
NRF21_RS27710 (29460) 29460..29585 - 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin Detail
NRF21_RS27715 (29527) 29527..29676 - 150 Protein_37 plasmid maintenance protein Mok -
- (29662) 29662..29886 - 225 NuclAT_0 - Antitoxin Detail
- (29662) 29662..29886 - 225 NuclAT_0 - Antitoxin Detail
- (29662) 29662..29886 - 225 NuclAT_0 - Antitoxin Detail
- (29662) 29662..29886 - 225 NuclAT_0 - Antitoxin Detail
NRF21_RS27720 (29898) 29898..30617 - 720 WP_001276217.1 plasmid SOS inhibition protein A -
NRF21_RS27725 (30614) 30614..31048 - 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
NRF21_RS27730 (31117) 31117..33140 - 2024 Protein_40 ParB/RepB/Spo0J family partition protein -
NRF21_RS27735 (33201) 33201..33434 - 234 WP_000006003.1 DUF905 family protein -
NRF21_RS27740 (33492) 33492..34019 - 528 WP_000290834.1 single-stranded DNA-binding protein -
NRF21_RS27745 (34321) 34321..34770 + 450 Protein_43 hypothetical protein -
NRF21_RS27750 (34856) 34856..35419 - 564 WP_015059007.1 class I SAM-dependent methyltransferase -
NRF21_RS27755 (35466) 35466..36827 - 1362 WP_000170695.1 DUF3560 domain-containing protein -
NRF21_RS27760 (36879) 36879..37109 - 231 WP_000218642.1 hypothetical protein -
NRF21_RS27765 (37626) 37626..37780 + 155 Protein_47 hypothetical protein -
NRF21_RS27770 (38509) 38509..40176 + 1668 WP_012372796.1 group II intron reverse transcriptase/maturase -
NRF21_RS27775 (40490) 40490..40681 - 192 WP_001027493.1 hypothetical protein -
NRF21_RS27780 (40678) 40678..41100 - 423 WP_000271762.1 DUF1380 family protein -
NRF21_RS27785 (41147) 41147..41572 - 426 WP_001198928.1 antirestriction protein -
NRF21_RS27790 (41990) 41990..42766 - 777 WP_001383963.1 hypothetical protein -
NRF21_RS27795 (42817) 42817..43251 - 435 WP_000274503.1 DUF1380 family protein -
NRF21_RS27800 (43265) 43265..43486 - 222 WP_001104881.1 hypothetical protein -
NRF21_RS27805 (43487) 43487..44170 - 684 WP_000085883.1 DNA methylase -
NRF21_RS27810 (44247) 44247..44540 - 294 WP_032146011.1 hypothetical protein -
NRF21_RS27815 (44687) 44687..45649 + 963 WP_000959884.1 plasmid segregation protein ParM -
NRF21_RS27820 (45652) 45652..46002 + 351 WP_000361389.1 plasmid partitioning/stability family protein -
NRF21_RS27825 (46125) 46125..46406 - 282 WP_001333089.1 hypothetical protein -
NRF21_RS27830 (46534) 46534..46768 - 235 Protein_60 type II toxin-antitoxin system RelE/ParE family toxin -
NRF21_RS27835 (48217) 48217..48282 - 66 Protein_61 IS1 family transposase -
NRF21_RS27840 (48348) 48348..49052 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27845 (49475) 49475..50092 + 618 Protein_63 replication protein -
NRF21_RS27850 (50626) 50626..50904 + 279 WP_013213990.1 hypothetical protein -
NRF21_RS27855 (51015) 51015..51440 + 426 WP_013213989.1 antirestriction protein -
NRF21_RS27860 (51568) 51568..51723 + 156 WP_013213988.1 hypothetical protein -
NRF21_RS27865 (51769) 51769..52065 + 297 WP_013213987.1 transcriptional regulator -
NRF21_RS27870 (52169) 52169..53050 + 882 Protein_68 IS1182 family transposase ISKpn6 Transposase
NRF21_RS27875 (53300) 53300..54181 - 882 WP_004199234.1 Carbapenem-hydrolyzing beta-lactamase KPC ARG
NRF21_RS27880 (54457) 54457..55437 - 981 WP_013213985.1 IS481 family transposase ISKpn27 Transposase
NRF21_RS27885 (55560) 55560..56021 - 462 Protein_71 Tn3 family transposase TnpR_Tn3 Transposase
NRF21_RS27890 (56073) 56073..56777 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS27895 (57570) 57570..58133 - 564 WP_014343514.1 methyltransferase -
NRF21_RS27900 (58181) 58181..59536 - 1356 WP_014343515.1 DUF3560 domain-containing protein -
NRF21_RS27905 (59588) 59588..59818 - 231 WP_001568051.1 hypothetical protein -
NRF21_RS27910 (59910) 59910..60137 - 228 WP_001568050.1 hypothetical protein -
NRF21_RS27915 (60818) 60818..61138 - 321 WP_001568049.1 hypothetical protein -
NRF21_RS27920 (61173) 61173..61427 - 255 WP_011977779.1 DNA polymerase III subunit theta -
NRF21_RS27925 (61615) 61615..61806 - 192 WP_001568047.1 hypothetical protein -
NRF21_RS27930 (61849) 61849..62355 - 507 WP_013214014.1 antirestriction protein ArdA -
NRF21_RS27935 (62398) 62398..62826 - 429 WP_001568045.1 antirestriction protein -
NRF21_RS27940 (63507) 63507..64274 - 768 WP_013214013.1 hypothetical protein -
NRF21_RS27945 (64328) 64328..64747 - 420 WP_001568043.1 DUF1380 domain-containing protein -
NRF21_RS27950 (64757) 64757..64978 - 222 WP_001568042.1 hypothetical protein -
NRF21_RS27955 (64978) 64978..65679 - 702 WP_001568041.1 DNA methylase -
NRF21_RS27960 (65751) 65751..65920 - 170 Protein_86 hypothetical protein -
NRF21_RS27965 (66116) 66116..66346 - 231 WP_001568040.1 hypothetical protein -
NRF21_RS27970 (66409) 66409..67080 - 672 WP_013214012.1 plasmid partitioning/stability family protein -
NRF21_RS27975 (67083) 67083..68054 - 972 WP_004152353.1 plasmid segregation protein ParM -
NRF21_RS27980 (68303) 68303..69790 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
NRF21_RS27985 (70197) 70197..70628 + 432 WP_001568036.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
NRF21_RS27990 (70628) 70628..71899 + 1272 WP_013214011.1 Y-family DNA polymerase -
NRF21_RS27995 (71981) 71981..72955 - 975 WP_011977819.1 ParB family protein -
NRF21_RS28000 (72955) 72955..74160 - 1206 WP_011977818.1 AAA family ATPase -
NRF21_RS28005 (75270) 75270..76136 - 867 WP_004118283.1 replication initiation protein -
NRF21_RS28010 (76672) 76672..76785 + 114 WP_014343462.1 hypothetical protein -
NRF21_RS28015 (76914) 76914..77171 + 258 WP_013214010.1 hypothetical protein -
NRF21_RS28020 (77217) 77217..77996 - 780 WP_013214009.1 site-specific integrase -
NRF21_RS28025 (78180) 78180..79184 - 1005 WP_011977814.1 hypothetical protein -
NRF21_RS28030 (79214) 79214..79417 - 204 WP_011977813.1 hypothetical protein -
NRF21_RS28035 (79463) 79463..79984 - 522 WP_013214008.1 hypothetical protein -
NRF21_RS28040 (80042) 80042..80434 - 393 WP_011977811.1 hypothetical protein -
NRF21_RS28045 (80471) 80471..81415 - 945 WP_011977810.1 hypothetical protein -
NRF21_RS28050 (81576) 81576..81821 - 246 Protein_104 hypothetical protein -
NRF21_RS28055 (82000) 82000..82974 - 975 WP_004213565.1 sensor domain-containing diguanylate cyclase -
NRF21_RS28060 (83611) 83611..84519 + 909 WP_023302803.1 HNH endonuclease -
NRF21_RS28065 (84906) 84906..85256 - 351 WP_004213569.1 DUF305 domain-containing protein -
NRF21_RS28070 (85400) 85400..85831 - 432 WP_023302802.1 silver-binding protein SilE -
NRF21_RS28075 (86082) 86082..87557 - 1476 WP_000555737.1 copper/silver sensor histidine kinase SilS -
NRF21_RS28080 (87550) 87550..88230 - 681 WP_004213574.1 Transcriptional regulatory protein CusR VF
NRF21_RS28085 (88420) 88420..89805 + 1386 WP_004213577.1 Cation efflux system protein CusC VF
NRF21_RS28090 (89834) 89834..90196 + 363 WP_004213578.1 cation efflux system protein CusF -
NRF21_RS28095 (90310) 90310..91602 + 1293 WP_004213579.1 Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB -
NRF21_RS28100 (91613) 91613..94759 + 3147 WP_004098958.1 Cu(+)/Ag(+) efflux RND transporter permease subunit SilA -
NRF21_RS28105 (94846) 94846..95286 + 441 WP_000758228.1 DUF411 domain-containing protein -
NRF21_RS28110 (95413) 95413..97860 + 2448 WP_004098955.1 Ag(+)-translocating P-type ATPase SilP -
NRF21_RS28115 (97901) 97901..98098 + 198 WP_000843497.1 DUF2933 domain-containing protein -
NRF21_RS28120 (98132) 98132..98869 - 738 WP_004118669.1 Murein DD-endopeptidase MepM VF
NRF21_RS28125 (99136) 99136..99603 - 468 WP_048336866.1 hypothetical protein -
NRF21_RS28130 (99837) 99837..101654 + 1818 WP_004213580.1 multicopper oxidase PcoA -
NRF21_RS28135 (101660) 101660..102550 + 891 WP_029884201.1 copper resistance outer membrane transporter PcoB -
NRF21_RS28140 (102590) 102590..102970 + 381 WP_000025662.1 copper resistance system metallochaperone PcoC -
NRF21_RS28145 (102975) 102975..103904 + 930 WP_004213583.1 copper resistance inner membrane protein PcoD -
NRF21_RS28150 (103959) 103959..104639 + 681 WP_001188930.1 Transcriptional activator protein CopR VF
NRF21_RS28155 (104636) 104636..106036 + 1401 WP_004152084.1 copper resistance membrane spanning protein PcoS -
NRF21_RS28160 (106564) 106564..107568 - 1005 WP_000427619.1 IS110 family transposase IS5075 Transposase
NRF21_RS28165 (107647) 107647..108081 - 435 WP_000429836.1 IS607 family transposase ISChh1 Transposase
NRF21_RS28170 (108153) 108153..108503 + 351 WP_001294663.1 mercuric transport protein MerT -
NRF21_RS28175 (108517) 108517..108792 + 276 WP_000732292.1 mercury resistance system periplasmic binding protein MerP -
NRF21_RS28180 (108828) 108828..109250 + 423 WP_001340589.1 organomercurial transporter MerC -
NRF21_RS28185 (109302) 109302..110996 + 1695 WP_000105636.1 mercury(II) reductase -
NRF21_RS28190 (111014) 111014..111376 + 363 WP_001277456.1 mercury resistance co-regulator MerD -
NRF21_RS28195 (111373) 111373..111609 + 237 WP_000993386.1 broad-spectrum mercury transporter MerE -
NRF21_RS28200 (111645) 111645..112313 + 669 WP_001300294.1 putative signaling protein VF
NRF21_RS28205 (112388) 112388..113560 + 1173 Protein_135 transposase -
NRF21_RS28210 (113625) 113625..114329 + 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS28215 (114493) 114493..115035 + 543 WP_014343512.1 single-stranded DNA-binding protein -
NRF21_RS28220 (115084) 115084..115332 + 249 WP_001568055.1 DUF905 domain-containing protein -
NRF21_RS28225 (115402) 115402..117459 + 2058 WP_015493064.1 ParB/RepB/Spo0J family partition protein -
NRF21_RS28230 (117504) 117504..117935 + 432 WP_001568057.1 conjugation system SOS inhibitor PsiB -
NRF21_RS28235 (117932) 117932..118660 + 729 WP_001568058.1 plasmid SOS inhibition protein A -
NRF21_RS28240 (118657) 118657..118983 + 327 WP_013023807.1 hypothetical protein -
NRF21_RS28245 (119039) 119039..119413 + 375 WP_014343510.1 hypothetical protein -
NRF21_RS28250 (119583) 119583..119732 + 150 Protein_144 FlmC family protein -
NRF21_RS28255 (119683) 119683..119799 + 117 WP_055313929.1 type I toxin-antitoxin system Hok family toxin -
NRF21_RS28260 (120492) 120492..120764 + 273 WP_040245921.1 hypothetical protein -
NRF21_RS28265 (120761) 120761..121111 + 351 WP_040245917.1 hypothetical protein -
NRF21_RS28270 (121126) 121126..121443 + 318 WP_014343505.1 hypothetical protein -
NRF21_RS28275 (122284) 122284..122640 + 357 WP_014343501.1 hypothetical protein -
NRF21_RS28280 (122701) 122701..122913 + 213 WP_014343500.1 hypothetical protein -
NRF21_RS28285 (122924) 122924..123148 + 225 WP_014343499.1 hypothetical protein -
NRF21_RS28290 (123229) 123229..123549 + 321 WP_014343498.1 type II toxin-antitoxin system RelE/ParE family toxin -
NRF21_RS28295 (123539) 123539..123817 + 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
NRF21_RS28300 (123821) 123821..123925 + 105 Protein_154 transcriptional regulator -
NRF21_RS28305 (124756) 124756..125577 + 822 WP_004152492.1 DUF932 domain-containing protein -
NRF21_RS28310 (125610) 125610..125939 + 330 WP_013214015.1 DUF5983 family protein -
NRF21_RS28315 (125972) 125972..126457 - 486 WP_014343495.1 hypothetical protein VF
NRF21_RS28320 (126848) 126848..127264 + 417 WP_014343494.1 conjugal transfer relaxosome DNA-binding protein TraM -
NRF21_RS28325 (127464) 127464..128201 + 738 WP_154244330.1 conjugal transfer protein TrbJ -
NRF21_RS28330 (128316) 128316..128522 + 207 WP_171773970.1 TraY domain-containing protein -
NRF21_RS28335 (128584) 128584..128952 + 369 WP_004194426.1 type IV conjugative transfer system pilin TraA -
NRF21_RS28340 (128966) 128966..129271 + 306 WP_004144424.1 type IV conjugative transfer system protein TraL -
NRF21_RS28345 (129291) 129291..129656 + 366 Protein_163 type IV conjugative transfer system protein TraE -
NRF21_RS28350 (129711) 129711..130055 - 345 Protein_164 IS6 family transposase IS26 Transposase
NRF21_RS28355 (130107) 130107..130811 - 705 WP_001067855.1 IS6 family transposase IS26 Transposase
NRF21_RS28360 (130836) 130836..131036 + 201 WP_072354025.1 hypothetical protein -
NRF21_RS28365 (131056) 131056..131802 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
NRF21_RS28370 (131857) 131857..132417 + 561 WP_000139328.1 fertility inhibition protein FinO -
NRF21_RS28375 (132549) 132549..132749 + 201 WP_015059022.1 hypothetical protein -
NRF21_RS28380 (133135) 133135..133734 + 600 WP_032083981.1 PIN domain-containing protein -
NRF21_RS28385 (133796) 133796..134128 + 333 WP_152916585.1 hypothetical protein -
- (134329) 134329..134388 - 60 NuclAT_1 - Antitoxin Detail
- (134329) 134329..134388 - 60 NuclAT_1 - Antitoxin Detail
- (134329) 134329..134388 - 60 NuclAT_1 - Antitoxin Detail
- (134329) 134329..134388 - 60 NuclAT_1 - Antitoxin Detail
NRF21_RS28390 (134433) 134433..134582 + 150 WP_001312851.1 Hok/Gef family protein Toxin Detail
NRF21_RS28395 (134866) 134866..135114 + 249 WP_000083837.1 replication regulatory protein RepA -
NRF21_RS28400 (135229) 135229..135413 + 185 Protein_174 protein CopA/IncA -

Similar MGE(s)


Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.

Detail Organism MGE type Related TA Genome accession Coordinates Mash
distance