MGE detailed information
MGE type: Conjugative plasmid MGE length: 138402 bp
Accession: NZ_CP086617 Location: 1..138402 Organism: Escherichia coli strain RIVM_C039629 Replicon: plasmid pRIVM_C039629_1
Accession: NZ_CP086617 Location: 1..138402 Organism: Escherichia coli strain RIVM_C039629 Replicon: plasmid pRIVM_C039629_1
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LN353_RS24870 () | 1..261 | + | 261 | WP_000083819.1 | replication regulatory protein RepA | - |
| LN353_RS24875 () | 486..560 | + | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| LN353_RS24880 () | 553..1410 | + | 858 | WP_000130647.1 | incFII family plasmid replication initiator RepA | - |
| LN353_RS24885 () | 2349..3002 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| LN353_RS24890 () | 3095..3352 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| LN353_RS24895 () | 3285..3686 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| LN353_RS24900 () | 3935..4350 | + | 416 | Protein_6 | IS1-like element IS1B family transposase | - |
| LN353_RS24905 () | 4386..4931 | - | 546 | Protein_7 | Tn3 family transposase TnpA_Tn3 | Transposase |
| LN353_RS24910 () | 4997..5701 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LN353_RS24915 () | 5768..6698 | - | 931 | Protein_9 | IS3 family transposase | - |
| LN353_RS24920 () | 6818..7738 | - | 921 | Protein_10 | IS4 family transposase IS4 | Transposase |
| LN353_RS24925 () | 7877..8671 | + | 795 | WP_063625815.1 | 3-methyl-2-oxobutanoate hydroxymethyltransferase | - |
| LN353_RS24930 () | 8683..9534 | + | 852 | WP_032248272.1 | pantoate--beta-alanine ligase | - |
| LN353_RS24935 () | 9679..9753 | - | 75 | Protein_13 | hypothetical protein | - |
| LN353_RS24940 () | 9832..10072 | + | 241 | Protein_14 | polysaccharide deacetylase family protein | - |
| LN353_RS24945 () | 10076..10456 | - | 381 | WP_000621515.1 | aspartate 1-decarboxylase | - |
| LN353_RS24950 () | 10730..10861 | + | 132 | Protein_16 | Rpn family recombination-promoting nuclease/putative transposase | - |
| LN353_RS24955 () | 11059..12453 | + | 1395 | WP_050488426.1 | MFS transporter | - |
| LN353_RS24960 () | 12559..13590 | + | 1032 | WP_000194408.1 | LacI family DNA-binding transcriptional regulator | - |
| LN353_RS24965 () | 13565..14584 | + | 1020 | WP_077758491.1 | nucleoside hydrolase | - |
| LN353_RS24970 () | 14701..15405 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LN353_RS24975 () | 15553..15657 | + | 105 | Protein_21 | integrase core domain-containing protein | - |
| LN353_RS24980 () | 15807..16805 | + | 999 | WP_004175650.1 | ABC transporter substrate-binding protein | - |
| LN353_RS24985 () | 16805..17842 | + | 1038 | WP_032248242.1 | Hemin transport system permease protein HmuU | VF |
| LN353_RS24990 () | 17842..18603 | + | 762 | WP_000020504.1 | Fe(3+) dicitrate transport ATP-binding protein FecE | VF |
| LN353_RS24995 () | 18660..19847 | + | 1188 | WP_162753250.1 | MFS transporter | - |
| LN353_RS25000 () | 19943..20923 | + | 981 | WP_063624983.1 | IS5 family transposase ISKpn26 | Transposase |
| LN353_RS25005 () | 21073..21705 | - | 633 | Protein_27 | histidine-type phosphatase | - |
| LN353_RS25010 () | 21827..22312 | - | 486 | WP_000874189.1 | hypothetical protein | - |
| LN353_RS25015 () | 22337..22822 | - | 486 | WP_001554949.1 | TlpA disulfide reductase family protein | - |
| LN353_RS25020 () | 22809..23504 | - | 696 | WP_063624982.1 | Lipoprotein-releasing system ATP-binding protein LolD | VF |
| LN353_RS25025 () | 23509..24237 | - | 729 | Protein_31 | FtsX-like permease family protein | - |
| LN353_RS25030 () | 24292..24996 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| LN353_RS25035 () | 25055..25804 | - | 750 | Protein_33 | IS91 family transposase ISAzo26 | Transposase |
| LN353_RS25040 () | 25962..26435 | + | 474 | WP_001389366.1 | trimethoprim-resistant dihydrofolate reductase DfrA17 | - |
| LN353_RS25045 () | 26566..27354 | + | 789 | WP_000503573.1 | Streptomycin 3''-adenylyltransferase | ARG |
| LN353_RS25050 () | 27560..27907 | + | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| LN353_RS25055 () | 27901..28740 | + | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| LN353_RS25060 () | 28868..29071 | + | 204 | WP_000376616.1 | hypothetical protein | - |
| LN353_RS25065 () | 29227..30432 | + | 1206 | WP_000184001.1 | chromate efflux transporter | - |
| LN353_RS25070 () | 30443..30748 | + | 306 | WP_000130000.1 | hypothetical protein | Relaxase |
| LN353_RS25075 () | 30792..30857 | + | 66 | Protein_41 | EAL domain-containing protein | - |
| LN353_RS25080 () | 30975..31739 | + | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| LN353_RS25085 () | 32232..32816 | - | 585 | WP_001137892.1 | macrolide-binding transcriptional repressor MphR(A) | - |
| LN353_RS25090 () | 32816..34054 | - | 1239 | WP_000004159.1 | macrolide resistance MFS transporter Mrx(A) | - |
| LN353_RS25095 () | 34051..34956 | - | 906 | WP_000219391.1 | hypothetical protein | ARG |
| LN353_RS25100 () | 35078..35782 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LN353_RS25105 () | 35843..36019 | + | 177 | Protein_47 | replication protein C, IncQ-type | - |
| LN353_RS25110 () | 36327..37142 | + | 816 | WP_001043260.1 | Dihydropteroate synthase | ARG |
| LN353_RS25115 () | 37203..38006 | + | 804 | WP_001082319.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| LN353_RS25120 () | 38006..38842 | + | 837 | WP_000480972.1 | hypothetical protein | ARG |
| LN353_RS25125 () | 38896..39132 | + | 237 | WP_042005022.1 | hypothetical protein | - |
| LN353_RS25130 () | 39164..39790 | - | 627 | WP_031606906.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| LN353_RS25135 () | 39896..41095 | + | 1200 | WP_000804064.1 | Tetracycline resistance protein, class C | ARG |
| LN353_RS25140 () | 41127..41987 | - | 861 | WP_000493383.1 | EamA family transporter | - |
| LN353_RS25145 () | 41996..42502 | - | 507 | Protein_55 | transposase | - |
| LN353_RS25150 () | 42555..43259 | - | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| LN353_RS25155 () | 43401..44276 | - | 876 | WP_032277257.1 | Beta-lactamase CTX-M-97 | ARG |
| LN353_RS25160 () | 44526..44705 | - | 180 | Protein_58 | IS1380 family transposase | - |
| LN353_RS25165 () | 44770..45474 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| LN353_RS25170 () | 45529..45813 | + | 285 | Protein_60 | integrase core domain-containing protein | - |
| LN353_RS25175 () | 45867..46904 | - | 1038 | WP_032248218.1 | LacI family DNA-binding transcriptional regulator | - |
| LN353_RS25185 () | 48776..49843 | + | 1068 | WP_032248209.1 | cellulase family glycosylhydrolase | - |
| LN353_RS25190 () | 49961..51325 | + | 1365 | WP_077758488.1 | MFS transporter | - |
| - () | 51602..51656 | - | 55 | NuclAT_1 | - | - |
| - () | 51602..51656 | - | 55 | NuclAT_1 | - | - |
| - () | 51602..51656 | - | 55 | NuclAT_1 | - | - |
| - () | 51602..51656 | - | 55 | NuclAT_1 | - | - |
| LN353_RS25195 () | 51824..53037 | - | 1214 | Protein_65 | IS3 family transposase | - |
| LN353_RS25200 () | 53092..53307 | + | 216 | Protein_66 | Tn3 family transposase | - |
| LN353_RS25205 () | 53384..53692 | + | 309 | Protein_67 | IS4 family transposase ISEc13 | Transposase |
| LN353_RS25210 () | 53751..55061 | - | 1311 | WP_000476108.1 | ABC transporter substrate-binding protein | - |
| LN353_RS25215 () | 55054..56127 | - | 1074 | WP_000950177.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | VF |
| LN353_RS25220 () | 56133..56957 | - | 825 | WP_000922702.1 | phosphodiesterase | - |
| LN353_RS25225 () | 56968..57855 | - | 888 | WP_001271561.1 | carbohydrate ABC transporter permease | - |
| LN353_RS25230 () | 57845..58723 | - | 879 | WP_162753243.1 | sugar ABC transporter permease | - |
| LN353_RS25235 () | 58854..59420 | - | 567 | Protein_73 | zinc-binding dehydrogenase | - |
| LN353_RS25240 () | 59773..60663 | + | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
| LN353_RS25245 () | 60688..61068 | + | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
| LN353_RS25250 () | 61101..62066 | + | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
| LN353_RS25255 () | 62112..62864 | - | 753 | WP_001403368.1 | IclR family transcriptional regulator | - |
| LN353_RS25260 () | 63469..63753 | + | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin Detail |
| LN353_RS25265 () | 63753..64028 | + | 276 | WP_000421273.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin Detail |
| LN353_RS25270 () | 64134..64337 | + | 204 | Protein_80 | hypothetical protein | - |
| LN353_RS25275 () | 64462..64590 | - | 129 | Protein_81 | IS481 family transposase | - |
| LN353_RS25280 () | 64623..65792 | - | 1170 | WP_001403369.1 | hypothetical protein | - |
| LN353_RS25285 () | 66324..66592 | + | 269 | Protein_83 | type II toxin-antitoxin system ParD family antitoxin | - |
| LN353_RS25290 () | 66579..66869 | + | 291 | Protein_84 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LN353_RS25295 () | 66936..67118 | + | 183 | WP_042344623.1 | hypothetical protein | - |
| LN353_RS25300 () | 67239..67979 | + | 741 | WP_001066941.1 | tyrosine-type recombinase/integrase | - |
| LN353_RS25305 () | 68222..69199 | - | 978 | WP_001309253.1 | RepB family plasmid replication initiator protein | - |
| LN353_RS25310 () | 70374..71015 | - | 642 | WP_000990667.1 | hypothetical protein | - |
| LN353_RS25315 () | 73337..73555 | + | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| LN353_RS25320 () | 73557..73862 | + | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| LN353_RS25325 () | 73863..74672 | + | 810 | WP_000016979.1 | site-specific integrase | - |
| LN353_RS25330 () | 74810..75085 | - | 276 | WP_000239529.1 | hypothetical protein | - |
| LN353_RS25335 () | 75079..75723 | - | 645 | WP_000633911.1 | AAA family ATPase | - |
| LN353_RS25340 () | 75952..76923 | + | 972 | WP_001103694.1 | plasmid segregation protein ParM | - |
| LN353_RS25345 () | 76928..77320 | + | 393 | WP_000340835.1 | plasmid partitioning/stability family protein | - |
| LN353_RS25350 () | 77325..77576 | - | 252 | Protein_96 | DUF4113 domain-containing protein | - |
| LN353_RS25355 () | 77638..78435 | - | 798 | WP_000544830.1 | IS21 family transposase IS21 | Transposase |
| LN353_RS25360 () | 78435..79607 | - | 1173 | WP_000952372.1 | IS21 family transposase IS21 | Transposase |
| LN353_RS25365 () | 79709..80730 | - | 1022 | Protein_99 | translesion error-prone DNA polymerase V subunit UmuC | - |
| LN353_RS25370 () | 80730..81167 | - | 438 | WP_000109079.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| LN353_RS25375 () | 81164..81412 | - | 249 | WP_000619112.1 | DinI-like family protein | - |
| LN353_RS25380 () | 81547..82065 | + | 519 | WP_000115885.1 | hypothetical protein | VF |
| LN353_RS25385 () | 82084..83304 | + | 1221 | WP_000343766.1 | ISL3 family transposase ISEc53 | Transposase |
| LN353_RS25390 () | 83723..84625 | + | 903 | WP_001310012.1 | DUF1281 domain-containing protein | - |
| LN353_RS25395 () | 84622..84933 | + | 312 | WP_001310011.1 | hypothetical protein | - |
| LN353_RS25400 () | 85009..85692 | + | 684 | WP_000086169.1 | DNA methylase | - |
| LN353_RS25405 () | 85693..85914 | + | 222 | WP_001104873.1 | hypothetical protein | - |
| LN353_RS25410 () | 85844..86362 | + | 519 | WP_223364201.1 | DUF1380 family protein | - |
| LN353_RS25415 () | 86407..87177 | + | 771 | WP_001004562.1 | hypothetical protein | - |
| LN353_RS25420 () | 87593..88018 | + | 426 | WP_001198903.1 | antirestriction protein | - |
| LN353_RS25425 () | 88065..88487 | + | 423 | WP_000271708.1 | DUF1380 family protein | - |
| LN353_RS25430 () | 88484..88675 | + | 192 | WP_001027516.1 | hypothetical protein | - |
| LN353_RS25435 () | 89638..89868 | + | 231 | WP_000155844.1 | hypothetical protein | - |
| LN353_RS25440 () | 89920..91281 | + | 1362 | WP_000170667.1 | DUF3560 domain-containing protein | - |
| LN353_RS25445 () | 91328..91891 | + | 564 | WP_001311069.1 | class I SAM-dependent methyltransferase | - |
| LN353_RS25450 () | 91891..92121 | + | 231 | WP_001333093.1 | hypothetical protein | - |
| LN353_RS25455 () | 92043..92291 | + | 249 | WP_071606928.1 | hypothetical protein | - |
| LN353_RS25460 () | 92761..93288 | + | 528 | WP_000290793.1 | single-stranded DNA-binding protein | - |
| LN353_RS25465 () | 93344..93577 | + | 234 | WP_000006018.1 | DUF905 domain-containing protein | - |
| LN353_RS25470 () | 93636..95594 | + | 1959 | WP_032152921.1 | ParB/RepB/Spo0J family partition protein | - |
| LN353_RS25475 () | 95649..96083 | + | 435 | WP_000845901.1 | conjugation system SOS inhibitor PsiB | - |
| LN353_RS25480 () | 96080..96842 | + | 763 | Protein_122 | plasmid SOS inhibition protein A | - |
| LN353_RS25485 () | 96811..96999 | - | 189 | WP_001299721.1 | hypothetical protein | - |
| - () | 96811..97035 | + | 225 | NuclAT_0 | - | - |
| - () | 96811..97035 | + | 225 | NuclAT_0 | - | - |
| - () | 96811..97035 | + | 225 | NuclAT_0 | - | - |
| - () | 96811..97035 | + | 225 | NuclAT_0 | - | - |
| - | 96968..97033 | - | 66 | - | - | Antitoxin Detail |
| LN353_RS25490 () | 97021..97170 | + | 150 | Protein_124 | plasmid maintenance protein Mok | - |
| LN353_RS25495 () | 97112..97237 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| LN353_RS25500 () | 97457..97687 | + | 231 | WP_071587244.1 | hypothetical protein | - |
| LN353_RS25505 () | 97685..97858 | - | 174 | Protein_127 | hypothetical protein | - |
| LN353_RS25510 () | 98156..98443 | + | 288 | WP_000107537.1 | hypothetical protein | - |
| LN353_RS25515 () | 98564..99385 | + | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| LN353_RS25520 () | 99682..100329 | - | 648 | WP_124760006.1 | hypothetical protein | VF |
| LN353_RS25525 () | 100615..100998 | + | 384 | WP_001151564.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| LN353_RS25530 () | 101192..101878 | + | 687 | WP_000332487.1 | PAS domain-containing protein | - |
| LN353_RS25535 () | 101972..102199 | + | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
| LN353_RS25540 () | 102233..102595 | + | 363 | WP_001098998.1 | type IV conjugative transfer system pilin TraA | - |
| LN353_RS25545 () | 102600..102911 | + | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| LN353_RS25550 () | 102933..103499 | + | 567 | WP_000399804.1 | type IV conjugative transfer system protein TraE | - |
| LN353_RS25555 () | 103486..104214 | + | 729 | WP_001230787.1 | type-F conjugative transfer system secretin TraK | - |
| LN353_RS25560 () | 104214..105641 | + | 1428 | WP_000146638.1 | F-type conjugal transfer pilus assembly protein TraB | - |
| LN353_RS25565 () | 105631..106215 | + | 585 | WP_000002795.1 | conjugal transfer pilus-stabilizing protein TraP | - |
| LN353_RS25570 () | 106202..106522 | + | 321 | WP_001057302.1 | conjugal transfer protein TrbD | - |
| LN353_RS25575 () | 106515..106766 | + | 252 | WP_001038341.1 | conjugal transfer protein TrbG | - |
| LN353_RS25580 () | 106763..107278 | + | 516 | WP_000809893.1 | type IV conjugative transfer system lipoprotein TraV | - |
| LN353_RS25585 () | 107413..107634 | + | 222 | WP_001278978.1 | conjugal transfer protein TraR | - |
| LN353_RS25590 () | 107794..110420 | + | 2627 | Protein_144 | type IV secretion system protein TraC | - |
| LN353_RS25595 () | 110417..110803 | + | 387 | WP_000214082.1 | type-F conjugative transfer system protein TrbI | - |
| LN353_RS25600 () | 110800..111432 | + | 633 | WP_001203720.1 | type-F conjugative transfer system protein TraW | - |
| LN353_RS25605 () | 111429..112421 | + | 993 | WP_000830838.1 | conjugal transfer pilus assembly protein TraU | - |
| LN353_RS25610 () | 112451..112756 | + | 306 | WP_000224411.1 | hypothetical protein | - |
| LN353_RS25615 () | 112765..113403 | + | 639 | WP_001080257.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| LN353_RS25620 () | 113400..115208 | + | 1809 | WP_024221016.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| LN353_RS25625 () | 115235..115492 | + | 258 | WP_000864320.1 | conjugal transfer protein TrbE | - |
| LN353_RS25630 () | 115485..116228 | + | 744 | WP_001749618.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| LN353_RS25635 () | 116244..116582 | + | 339 | WP_001287905.1 | conjugal transfer protein TrbA | - |
| LN353_RS25640 () | 116709..116993 | + | 285 | WP_001448202.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| LN353_RS25645 () | 116980..117525 | + | 546 | WP_000059824.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| LN353_RS25650 () | 117455..117796 | + | 342 | WP_001448115.1 | P-type conjugative transfer protein TrbJ | - |
| LN353_RS25655 () | 117777..118169 | + | 393 | WP_000660703.1 | F-type conjugal transfer protein TrbF | - |
| LN353_RS25660 () | 118156..119529 | + | 1374 | WP_001137364.1 | conjugal transfer pilus assembly protein TraH | - |
| LN353_RS25665 () | 119526..122345 | + | 2820 | WP_001007057.1 | conjugal transfer mating-pair stabilization protein TraG | - |
| LN353_RS25670 () | 122364..122861 | + | 498 | WP_000605861.1 | hypothetical protein | - |
| LN353_RS25675 () | 122893..123624 | + | 732 | WP_024221017.1 | conjugal transfer complement resistance protein TraT | - |
| LN353_RS25680 () | 123877..126075 | + | 2199 | WP_032302075.1 | type IV conjugative transfer system coupling protein TraD | - |
| LN353_RS25685 () | 126075..131345 | + | 5271 | WP_048967012.1 | Multifunctional conjugation protein TraI | Relaxase |
| LN353_RS25690 () | 131365..132111 | + | 747 | WP_000205725.1 | conjugal transfer pilus acetylase TraX | - |
| LN353_RS25695 () | 132170..133030 | + | 861 | WP_000704523.1 | putative protein YcjY | VF |
| LN353_RS25700 () | 133133..133693 | + | 561 | WP_000139321.1 | fertility inhibition protein FinO | - |
| LN353_RS25705 () | 133822..134034 | + | 213 | WP_001309245.1 | ANR family transcriptional regulator | - |
| LN353_RS25710 () | 134279..134422 | + | 144 | Protein_168 | endonuclease | - |
| LN353_RS25715 () | 134512..134937 | + | 426 | WP_000422741.1 | IS66 family transposase ISEc23 | Transposase |
| LN353_RS25720 () | 134934..135284 | + | 351 | WP_000624722.1 | IS66 family transposase ISEc23 | Transposase |
| LN353_RS25725 () | 135315..136928 | + | 1614 | WP_135118410.1 | IS66 family transposase ISEc23 | Transposase |
| LN353_RS25730 () | 136960..137280 | + | 321 | Protein_172 | thermonuclease family protein | - |
| LN353_RS25735 () | 137326..137535 | + | 210 | WP_001298565.1 | hemolysin expression modulator Hha | - |
| LN353_RS25740 () | 137573..138163 | + | 591 | WP_000766805.1 | DUF2726 domain-containing protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|