MGE detailed information
MGE type: Mobilizable plasmid MGE length: 115559 bp
Accession: NZ_CP082034 Location: 1..115559 Organism: Klebsiella pneumoniae strain KP18-2138 Replicon: plasmid pKP18-2138-KPC2
Accession: NZ_CP082034 Location: 1..115559 Organism: Klebsiella pneumoniae strain KP18-2138 Replicon: plasmid pKP18-2138-KPC2
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6163_RS27955 (1) | 1..858 | + | 858 | WP_142295464.1 | incFII family plasmid replication initiator RepA | - |
| K6163_RS27960 (1797) | 1797..2450 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| K6163_RS27965 (2543) | 2543..2800 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| K6163_RS27970 (2733) | 2733..3134 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| K6163_RS27975 (3383) | 3383..3798 | + | 416 | Protein_4 | IS1 family transposase IS1R | Transposase |
| K6163_RS27980 (3834) | 3834..4379 | - | 546 | Protein_5 | Tn3 family transposase TnpA_Tn3 | Transposase |
| K6163_RS27985 (4445) | 4445..5149 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS27990 (5215) | 5215..5727 | + | 513 | Protein_7 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| K6163_RS27995 (5751) | 5751..6299 | - | 549 | WP_050497034.1 | Tn3 family transposase TnpR_Tn5403 | Transposase |
| K6163_RS28000 (6305) | 6305..7009 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS28010 (8589) | 8589..8823 | + | 235 | Protein_10 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K6163_RS28015 (8951) | 8951..9232 | + | 282 | WP_001333089.1 | hypothetical protein | - |
| K6163_RS28020 (9355) | 9355..9705 | - | 351 | WP_000361389.1 | plasmid partitioning/stability family protein | - |
| K6163_RS28025 (9708) | 9708..10670 | - | 963 | WP_000959884.1 | plasmid segregation protein ParM | - |
| K6163_RS28030 (10817) | 10817..11110 | + | 294 | WP_032146011.1 | hypothetical protein | - |
| K6163_RS28035 (11187) | 11187..11870 | + | 684 | WP_000085883.1 | DNA methylase | - |
| K6163_RS28040 (11871) | 11871..12092 | + | 222 | WP_001104881.1 | hypothetical protein | - |
| K6163_RS28045 (12106) | 12106..12540 | + | 435 | WP_000274503.1 | DUF1380 family protein | - |
| K6163_RS28050 (12591) | 12591..13367 | + | 777 | WP_001383963.1 | hypothetical protein | - |
| K6163_RS28055 (13785) | 13785..14210 | + | 426 | WP_001198928.1 | antirestriction protein | - |
| K6163_RS28060 (14257) | 14257..14679 | + | 423 | WP_000271762.1 | DUF1380 family protein | - |
| K6163_RS28065 (14676) | 14676..14867 | + | 192 | WP_001027493.1 | hypothetical protein | - |
| K6163_RS28070 (15181) | 15181..16848 | - | 1668 | WP_012372796.1 | group II intron reverse transcriptase/maturase | - |
| K6163_RS29005 (17577) | 17577..17731 | - | 155 | Protein_23 | hypothetical protein | - |
| K6163_RS28075 (18248) | 18248..18478 | + | 231 | WP_000218642.1 | hypothetical protein | - |
| K6163_RS28080 (18530) | 18530..19891 | + | 1362 | WP_000170695.1 | DUF3560 domain-containing protein | - |
| K6163_RS28085 (19938) | 19938..20501 | + | 564 | WP_015059007.1 | class I SAM-dependent methyltransferase | - |
| K6163_RS29010 (20587) | 20587..21048 | - | 462 | Protein_27 | hypothetical protein | - |
| K6163_RS28090 (21350) | 21350..21877 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
| K6163_RS28095 (21935) | 21935..22168 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
| K6163_RS28100 (22229) | 22229..24252 | + | 2024 | Protein_30 | ParB/RepB/Spo0J family partition protein | - |
| K6163_RS28105 (24321) | 24321..24755 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| K6163_RS28110 (24752) | 24752..25471 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| - (25483) | 25483..25707 | + | 225 | NuclAT_0 | - | - |
| - (25483) | 25483..25707 | + | 225 | NuclAT_0 | - | - |
| - (25483) | 25483..25707 | + | 225 | NuclAT_0 | - | - |
| - (25483) | 25483..25707 | + | 225 | NuclAT_0 | - | - |
| K6163_RS29015 (25693) | 25693..25842 | + | 150 | Protein_33 | plasmid maintenance protein Mok | - |
| K6163_RS28115 (25784) | 25784..25909 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| K6163_RS28120 (26228) | 26228..26524 | - | 297 | Protein_35 | hypothetical protein | - |
| K6163_RS28125 (26824) | 26824..27120 | + | 297 | WP_001272251.1 | hypothetical protein | - |
| K6163_RS28130 (27231) | 27231..28052 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| K6163_RS28135 (28349) | 28349..28996 | - | 648 | WP_015059008.1 | hypothetical protein | VF |
| K6163_RS28140 (29273) | 29273..29656 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| K6163_RS28145 (29847) | 29847..30533 | + | 687 | WP_015059009.1 | PAS domain-containing protein | - |
| K6163_RS28150 (30627) | 30627..30854 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
| K6163_RS28155 (30888) | 30888..31253 | + | 366 | WP_021519752.1 | type IV conjugative transfer system pilin TraA | - |
| K6163_RS28160 (31268) | 31268..31579 | + | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| K6163_RS28165 (31601) | 31601..32167 | + | 567 | WP_000399794.1 | type IV conjugative transfer system protein TraE | - |
| K6163_RS28170 (32154) | 32154..32882 | + | 729 | WP_001230787.1 | type-F conjugative transfer system secretin TraK | - |
| K6163_RS28175 (32882) | 32882..33085 | + | 204 | Protein_46 | IS6 family transposase IS15 | Transposase |
| K6163_RS28180 (33151) | 33151..33854 | + | 704 | Protein_47 | IS6 family transposase IS15DI | Transposase |
| K6163_RS28185 (33908) | 33908..34231 | - | 324 | Protein_48 | class II aldolase/adducin family protein | - |
| K6163_RS28190 (34224) | 34224..35468 | - | 1245 | Protein_49 | four-carbon acid sugar kinase family protein | - |
| K6163_RS29020 (35581) | 35581..35730 | - | 150 | WP_228751112.1 | hypothetical protein | - |
| K6163_RS28195 (35761) | 35761..36198 | - | 438 | WP_267461421.1 | NAD(P)-binding domain-containing protein | - |
| K6163_RS29115 (36227) | 36227..36337 | - | 111 | Protein_52 | oxidoreductase | - |
| K6163_RS28200 (36648) | 36648..37409 | + | 762 | WP_002210513.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| K6163_RS28205 (37430) | 37430..38290 | - | 861 | WP_002904004.1 | Beta-lactamase SHV-2 | ARG |
| K6163_RS28210 (38427) | 38427..38495 | + | 69 | Protein_55 | IS6 family transposase | - |
| K6163_RS28215 (38531) | 38531..40430 | - | 1900 | Protein_56 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| K6163_RS28220 (40496) | 40496..41200 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS28225 (41252) | 41252..41713 | + | 462 | Protein_58 | Tn3 family transposase TnpR_Tn3 | Transposase |
| K6163_RS28230 (41836) | 41836..42816 | + | 981 | WP_013213985.1 | IS481 family transposase ISKpn27 | Transposase |
| K6163_RS28235 (43092) | 43092..43973 | + | 882 | WP_004199234.1 | Carbapenem-hydrolyzing beta-lactamase KPC | ARG |
| K6163_RS28240 (44223) | 44223..45104 | - | 882 | Protein_61 | IS1182 family transposase ISKpn6 | Transposase |
| K6163_RS28245 (45208) | 45208..45504 | - | 297 | WP_013213987.1 | transcriptional regulator | - |
| K6163_RS28250 (45550) | 45550..45705 | - | 156 | WP_013213988.1 | hypothetical protein | - |
| K6163_RS28255 (45833) | 45833..46258 | - | 426 | WP_013213989.1 | antirestriction protein | - |
| K6163_RS28260 (46369) | 46369..46647 | - | 279 | WP_013213990.1 | hypothetical protein | - |
| K6163_RS28265 (47181) | 47181..47798 | - | 618 | Protein_66 | replication protein | - |
| K6163_RS28270 (48190) | 48190..48750 | + | 561 | WP_001161490.1 | Tn3 family transposase TnpR_TnAs1 | Transposase |
| K6163_RS28275 (48754) | 48754..49827 | + | 1074 | Protein_68 | Tn3 family transposase TnpA_TnAs1 | Transposase |
| K6163_RS28280 (49880) | 49880..50584 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS28285 (50649) | 50649..51821 | - | 1173 | Protein_70 | transposase | - |
| K6163_RS28290 (51896) | 51896..52564 | - | 669 | WP_001300294.1 | putative signaling protein | VF |
| K6163_RS28295 (52600) | 52600..52836 | - | 237 | WP_000993386.1 | broad-spectrum mercury transporter MerE | - |
| K6163_RS28300 (52833) | 52833..53195 | - | 363 | WP_001277456.1 | mercury resistance co-regulator MerD | - |
| K6163_RS28305 (53213) | 53213..54907 | - | 1695 | WP_000105636.1 | mercury(II) reductase | - |
| K6163_RS28310 (54959) | 54959..55381 | - | 423 | WP_001340589.1 | organomercurial transporter MerC | - |
| K6163_RS28315 (55417) | 55417..55692 | - | 276 | WP_000732292.1 | mercury resistance system periplasmic binding protein MerP | - |
| K6163_RS28320 (55706) | 55706..56056 | - | 351 | WP_001294663.1 | mercuric transport protein MerT | - |
| K6163_RS28325 (56128) | 56128..56562 | + | 435 | WP_000429836.1 | IS607 family transposase ISChh1 | Transposase |
| K6163_RS28330 (56641) | 56641..57645 | + | 1005 | WP_000427619.1 | IS110 family transposase IS5075 | Transposase |
| K6163_RS28335 (57925) | 57925..58197 | - | 273 | Protein_80 | transposase | - |
| K6163_RS28345 (59179) | 59179..60201 | - | 1023 | WP_000361404.1 | helicase UvrD | - |
| K6163_RS28350 (60186) | 60186..61748 | - | 1563 | WP_004206609.1 | AAA family ATPase | - |
| K6163_RS28355 (61822) | 61822..62238 | - | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| K6163_RS28360 (62235) | 62235..62465 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| K6163_RS28365 (62422) | 62422..62883 | + | 462 | WP_014343465.1 | hypothetical protein | - |
| K6163_RS28370 (63044) | 63044..63988 | + | 945 | WP_011977810.1 | hypothetical protein | - |
| K6163_RS28375 (64025) | 64025..64417 | + | 393 | WP_011977811.1 | hypothetical protein | - |
| K6163_RS28380 (64475) | 64475..64996 | + | 522 | WP_013214008.1 | hypothetical protein | - |
| K6163_RS28385 (65042) | 65042..65245 | + | 204 | WP_011977813.1 | hypothetical protein | - |
| K6163_RS28390 (65275) | 65275..66279 | + | 1005 | WP_011977814.1 | hypothetical protein | - |
| K6163_RS28395 (66463) | 66463..67242 | + | 780 | WP_013214009.1 | site-specific integrase | - |
| K6163_RS28400 (67288) | 67288..67545 | - | 258 | WP_013214010.1 | hypothetical protein | - |
| K6163_RS28405 (67674) | 67674..67787 | - | 114 | WP_014343462.1 | hypothetical protein | - |
| K6163_RS28410 (68323) | 68323..69189 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| K6163_RS28415 (70299) | 70299..71504 | + | 1206 | WP_011977818.1 | AAA family ATPase | - |
| K6163_RS28420 (71504) | 71504..72478 | + | 975 | WP_011977819.1 | ParB family protein | - |
| K6163_RS28425 (72560) | 72560..73831 | - | 1272 | WP_013214011.1 | Y-family DNA polymerase | - |
| K6163_RS28430 (73831) | 73831..74262 | - | 432 | WP_001568036.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| K6163_RS28435 (74669) | 74669..76156 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| K6163_RS28440 (76405) | 76405..77376 | + | 972 | WP_004152353.1 | plasmid segregation protein ParM | - |
| K6163_RS28445 (77379) | 77379..78050 | + | 672 | WP_013214012.1 | plasmid partitioning/stability family protein | - |
| K6163_RS28450 (78113) | 78113..78343 | + | 231 | WP_001568040.1 | hypothetical protein | - |
| K6163_RS29025 (78539) | 78539..78708 | + | 170 | Protein_104 | hypothetical protein | - |
| K6163_RS28455 (78780) | 78780..79481 | + | 702 | WP_151488309.1 | DNA methylase | - |
| K6163_RS28460 (79481) | 79481..79702 | + | 222 | WP_001568042.1 | hypothetical protein | - |
| K6163_RS28465 (79712) | 79712..80131 | + | 420 | WP_001568043.1 | DUF1380 domain-containing protein | - |
| K6163_RS28470 (80185) | 80185..80952 | + | 768 | WP_013214013.1 | hypothetical protein | - |
| K6163_RS28475 (81633) | 81633..82061 | + | 429 | WP_001568045.1 | antirestriction protein | - |
| K6163_RS28480 (82104) | 82104..82610 | + | 507 | WP_013214014.1 | antirestriction protein ArdA | - |
| K6163_RS28485 (82653) | 82653..82844 | + | 192 | WP_001568047.1 | hypothetical protein | - |
| K6163_RS28490 (83032) | 83032..83286 | + | 255 | WP_011977779.1 | DNA polymerase III subunit theta | - |
| K6163_RS28495 (83321) | 83321..83641 | + | 321 | WP_001568049.1 | hypothetical protein | - |
| K6163_RS28500 (84321) | 84321..84548 | + | 228 | WP_001568050.1 | hypothetical protein | - |
| K6163_RS28505 (84640) | 84640..84870 | + | 231 | WP_001568051.1 | hypothetical protein | - |
| K6163_RS28510 (84922) | 84922..86277 | + | 1356 | WP_014343515.1 | DUF3560 domain-containing protein | - |
| K6163_RS28515 (86325) | 86325..86888 | + | 564 | WP_014343514.1 | methyltransferase | - |
| K6163_RS28520 (87720) | 87720..88262 | + | 543 | WP_014343512.1 | single-stranded DNA-binding protein | - |
| K6163_RS28525 (88311) | 88311..88559 | + | 249 | WP_001568055.1 | DUF905 domain-containing protein | - |
| K6163_RS28530 (88629) | 88629..90686 | + | 2058 | WP_015493064.1 | ParB/RepB/Spo0J family partition protein | - |
| K6163_RS28535 (90731) | 90731..91162 | + | 432 | WP_001568057.1 | conjugation system SOS inhibitor PsiB | - |
| K6163_RS28540 (91159) | 91159..91887 | + | 729 | WP_001568058.1 | plasmid SOS inhibition protein A | - |
| K6163_RS28545 (91884) | 91884..92210 | + | 327 | WP_013023807.1 | hypothetical protein | - |
| K6163_RS28550 (92266) | 92266..92640 | + | 375 | WP_014343510.1 | hypothetical protein | - |
| K6163_RS29030 (92810) | 92810..92959 | + | 150 | Protein_125 | DUF5431 family protein | - |
| K6163_RS28555 (92910) | 92910..93026 | + | 117 | WP_055313929.1 | type I toxin-antitoxin system Hok family toxin | - |
| K6163_RS28560 (93719) | 93719..93991 | + | 273 | WP_040245921.1 | hypothetical protein | - |
| K6163_RS28565 (93988) | 93988..94338 | + | 351 | WP_040245917.1 | hypothetical protein | - |
| K6163_RS28570 (94353) | 94353..94670 | + | 318 | WP_014343505.1 | hypothetical protein | - |
| K6163_RS28575 (95511) | 95511..95867 | + | 357 | WP_014343501.1 | hypothetical protein | - |
| K6163_RS28580 (95928) | 95928..96140 | + | 213 | WP_014343500.1 | hypothetical protein | - |
| K6163_RS28585 (96151) | 96151..96375 | + | 225 | WP_014343499.1 | hypothetical protein | - |
| K6163_RS28590 (96456) | 96456..96776 | + | 321 | WP_014343498.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K6163_RS28595 (96766) | 96766..97044 | + | 279 | WP_004152721.1 | helix-turn-helix transcriptional regulator | - |
| K6163_RS28600 (97142) | 97142..97846 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS28605 (98175) | 98175..99125 | + | 951 | WP_015493085.1 | Recombination-promoting nuclease RpnA | VF |
| K6163_RS28610 (99122) | 99122..99733 | - | 612 | WP_015493086.1 | DUF2913 family protein | - |
| K6163_RS28615 (99730) | 99730..100125 | - | 396 | WP_015493087.1 | hypothetical protein | - |
| K6163_RS28620 (100178) | 100178..100570 | - | 393 | Protein_139 | 3'-5' exonuclease | - |
| K6163_RS28625 (100639) | 100639..101619 | + | 981 | WP_000019445.1 | IS5 family transposase ISKpn26 | Transposase |
| K6163_RS28630 (101601) | 101601..102143 | + | 543 | WP_077273850.1 | restriction endonuclease | - |
| K6163_RS28635 (102271) | 102271..102828 | + | 558 | WP_042934582.1 | hypothetical protein | - |
| K6163_RS28640 (103297) | 103297..104001 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS28645 (104007) | 104007..104147 | + | 141 | WP_001044210.1 | hypothetical protein | - |
| K6163_RS28650 (104633) | 104633..105370 | + | 738 | WP_001446887.1 | Tn3 family transposase TnpR_TnEc1 | Transposase |
| K6163_RS28655 (105367) | 105367..105591 | + | 225 | WP_000743213.1 | hypothetical protein | - |
| K6163_RS29035 (105713) | 105713..105799 | + | 87 | Protein_147 | Arm DNA-binding domain-containing protein | - |
| K6163_RS28665 (106071) | 106071..107075 | - | 1005 | WP_000427619.1 | IS110 family transposase IS5075 | Transposase |
| K6163_RS28670 (107154) | 107154..110120 | - | 2967 | WP_042863651.1 | Tn3 family transposase TnpA_ISPa38 | Transposase |
| K6163_RS28675 (110123) | 110123..110188 | - | 66 | Protein_150 | helix-turn-helix domain-containing protein | - |
| K6163_RS28680 (110241) | 110241..110945 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| K6163_RS28685 (110970) | 110970..111170 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| K6163_RS28690 (111190) | 111190..111936 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| K6163_RS28695 (111991) | 111991..112551 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| K6163_RS28700 (112683) | 112683..112883 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| K6163_RS28705 (113269) | 113269..113868 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| K6163_RS28710 (113930) | 113930..114262 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (114463) | 114463..114522 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (114463) | 114463..114522 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (114463) | 114463..114522 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| - (114463) | 114463..114522 | - | 60 | NuclAT_1 | - | Antitoxin Detail |
| K6163_RS28715 (114567) | 114567..114716 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin Detail |
| K6163_RS28720 (115000) | 115000..115248 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| K6163_RS29040 (115363) | 115363..115547 | + | 185 | Protein_160 | protein CopA/IncA | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|