MGE detailed information
MGE type: Conjugative plasmid MGE length: 121872 bp
Accession: NZ_CP050384 Location: 1..121872 Organism: Escherichia coli strain 52148 Replicon: plasmid p52148_NDM_5
Accession: NZ_CP050384 Location: 1..121872 Organism: Escherichia coli strain 52148 Replicon: plasmid p52148_NDM_5
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HB638_RS23325 () | 599..1465 | + | 867 | Protein_1 | class 1 integron integrase IntI1 | - |
| HB638_RS23330 () | 1520..2224 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HB638_RS23335 () | 2290..3804 | + | 1515 | Protein_3 | Tn3-like element TnAs1 family transposase | - |
| HB638_RS23340 () | 3846..4088 | + | 243 | WP_032140899.1 | hypothetical protein | - |
| HB638_RS23345 () | 4120..4770 | - | 651 | WP_000164043.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| HB638_RS23350 () | 4876..6075 | + | 1200 | WP_000804064.1 | tetracycline efflux MFS transporter Tet(A) | - |
| HB638_RS23355 () | 6107..6991 | - | 885 | WP_000058717.1 | EamA family transporter | - |
| HB638_RS23360 () | 7129..7536 | - | 408 | WP_001214976.1 | cysteine hydrolase | - |
| HB638_RS23365 () | 7525..8274 | + | 750 | Protein_9 | Tn3 family transposase | - |
| HB638_RS23370 () | 8298..8903 | - | 606 | WP_000509965.1 | recombinase family protein | - |
| HB638_RS23375 () | 8998..11895 | + | 2898 | WP_001553819.1 | Tn3-like element Tn5403 family transposase | - |
| HB638_RS23380 () | 12032..12433 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| HB638_RS23385 () | 12366..12623 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| HB638_RS23390 () | 12716..13369 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| HB638_RS23395 () | 14308..15165 | - | 858 | WP_029702152.1 | incFII family plasmid replication initiator RepA | - |
| HB638_RS23400 () | 15158..15232 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| HB638_RS23405 () | 15468..15725 | - | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
| HB638_RS23410 () | 16009..16215 | - | 207 | WP_032215358.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 16202..16263 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| - () | 16202..16263 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| - () | 16202..16263 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| - () | 16202..16263 | + | 62 | NuclAT_1 | - | Antitoxin Detail |
| HB638_RS24100 () | 16402..16668 | - | 267 | WP_087757657.1 | hypothetical protein | - |
| HB638_RS23420 () | 17043..17612 | - | 570 | WP_029702150.1 | DUF2726 domain-containing protein | - |
| HB638_RS23425 () | 17764..18390 | - | 627 | WP_029702149.1 | hypothetical protein | - |
| HB638_RS23430 () | 18802..19011 | - | 210 | WP_039023209.1 | hypothetical protein | - |
| HB638_RS23435 () | 19142..19702 | - | 561 | WP_001567328.1 | fertility inhibition protein FinO | - |
| HB638_RS23440 () | 19757..20503 | - | 747 | WP_052273601.1 | conjugal transfer pilus acetylase TraX | - |
| HB638_RS23445 () | 20531..21277 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| HB638_RS23450 () | 21292..22833 | - | 1542 | WP_002431311.1 | IS21-like element ISEc12 family transposase | - |
| HB638_RS23455 () | 23109..28379 | - | 5271 | WP_039023145.1 | conjugative transfer relaxase/helicase TraI | - |
| HB638_RS23460 () | 28461..28688 | + | 228 | WP_039023146.1 | toxin-antitoxin system antitoxin VapB | Antitoxin Detail |
| HB638_RS23465 () | 28688..29086 | + | 399 | WP_039023147.1 | tRNA(fMet)-specific endonuclease VapC | Toxin Detail |
| HB638_RS23470 () | 29095..31338 | - | 2244 | WP_167317319.1 | type IV conjugative transfer system coupling protein TraD | - |
| HB638_RS23475 () | 31591..32322 | - | 732 | WP_000850422.1 | complement resistance protein TraT | - |
| HB638_RS23480 () | 32354..32851 | - | 498 | WP_000605862.1 | entry exclusion protein | - |
| HB638_RS23485 () | 32870..35689 | - | 2820 | WP_039023149.1 | conjugal transfer mating pair stabilization protein TraG | - |
| HB638_RS23490 () | 35686..37059 | - | 1374 | WP_039023150.1 | conjugal transfer protein TraH | - |
| HB638_RS23495 () | 37059..37421 | - | 363 | WP_071550055.1 | P-type conjugative transfer protein TrbJ | - |
| HB638_RS23500 () | 37351..37896 | - | 546 | WP_016236310.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| HB638_RS23505 () | 37883..38167 | - | 285 | WP_000624110.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| HB638_RS23510 () | 38286..38633 | - | 348 | WP_001287894.1 | conjugal transfer protein TrbA | - |
| HB638_RS23515 () | 38649..39392 | - | 744 | WP_001030376.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| HB638_RS23520 () | 39385..39642 | - | 258 | WP_039023152.1 | conjugal transfer protein TrbE | - |
| HB638_RS23525 () | 39669..41477 | - | 1809 | WP_039023153.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| HB638_RS23530 () | 41474..42112 | - | 639 | WP_001553832.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| HB638_RS23535 () | 42121..43113 | - | 993 | WP_001553833.1 | conjugal transfer pilus assembly protein TraU | - |
| HB638_RS23540 () | 43110..43742 | - | 633 | WP_001203720.1 | type-F conjugative transfer system protein TraW | - |
| HB638_RS23545 () | 43739..44125 | - | 387 | WP_000099690.1 | type-F conjugative transfer system protein TrbI | - |
| HB638_RS23550 () | 44122..46749 | - | 2628 | WP_001064264.1 | type IV secretion system protein TraC | - |
| HB638_RS23555 () | 46909..47130 | - | 222 | WP_001278692.1 | conjugal transfer protein TraR | - |
| HB638_RS23560 () | 47265..47780 | - | 516 | WP_000809832.1 | type IV conjugative transfer system lipoprotein TraV | - |
| HB638_RS23565 () | 47777..48028 | - | 252 | WP_001038342.1 | conjugal transfer protein TrbG | - |
| HB638_RS23570 () | 48021..48182 | - | 162 | WP_000741714.1 | conjugal transfer protein TrbD | - |
| HB638_RS23575 () | 48204..48341 | - | 138 | WP_001553834.1 | conjugal transfer protein TrbD | - |
| HB638_RS23580 () | 48328..48918 | - | 591 | WP_000002787.1 | conjugal transfer protein TraP | - |
| HB638_RS23585 () | 48908..50335 | - | 1428 | WP_001553836.1 | conjugal transfer protein TraB | - |
| HB638_RS23590 () | 50335..51039 | - | 705 | WP_148713163.1 | type-F conjugative transfer system secretin TraK | - |
| HB638_RS23595 () | 51050..51616 | - | 567 | WP_000399790.1 | type IV conjugative transfer system protein TraE | - |
| HB638_RS23600 () | 51638..51949 | - | 312 | WP_000012106.1 | type IV conjugative transfer system protein TraL | - |
| HB638_RS23605 () | 51964..52329 | - | 366 | WP_000340282.1 | type IV conjugative transfer system pilin TraA | - |
| HB638_RS23610 () | 52372..52587 | - | 216 | WP_001352842.1 | conjugal transfer relaxosome protein TraY | - |
| HB638_RS23615 () | 52723..53370 | - | 648 | WP_000332520.1 | conjugal transfer transcriptional regulator TraJ | - |
| HB638_RS23620 () | 53561..53944 | - | 384 | WP_001063020.1 | relaxosome protein TraM | - |
| HB638_RS23625 () | 54314..54886 | + | 573 | WP_000949660.1 | transglycosylase SLT domain-containing protein | - |
| HB638_RS23630 () | 55182..56003 | - | 822 | WP_001234465.1 | DUF945 domain-containing protein | - |
| HB638_RS23635 () | 56122..56409 | - | 288 | WP_000107242.1 | hypothetical protein | - |
| HB638_RS24105 () | 56434..56640 | - | 207 | WP_000275854.1 | hypothetical protein | - |
| HB638_RS23645 () | 57308..57466 | - | 159 | WP_001302184.1 | type I toxin-antitoxin system Hok family toxin | - |
| - () | 58985..59175 | - | 191 | NuclAT_0 | - | - |
| - () | 58985..59175 | - | 191 | NuclAT_0 | - | - |
| - () | 58985..59175 | - | 191 | NuclAT_0 | - | - |
| - () | 58985..59175 | - | 191 | NuclAT_0 | - | - |
| HB638_RS23655 () | 59144..59249 | - | 106 | Protein_67 | plasmid SOS inhibition protein A | - |
| HB638_RS23660 () | 59404..59721 | + | 318 | Protein_68 | IS110 family transposase | - |
| HB638_RS23665 () | 60010..60261 | - | 252 | Protein_69 | iron-containing alcohol dehydrogenase | - |
| HB638_RS23670 () | 60346..60969 | - | 624 | WP_000912556.1 | potassium channel family protein | - |
| HB638_RS23675 () | 60985..61678 | - | 694 | Protein_71 | IS1 family transposase | - |
| HB638_RS23680 () | 61735..61839 | + | 105 | Protein_72 | thiosulfate reductase cytochrome B subunit | - |
| HB638_RS23685 () | 62085..63479 | - | 1395 | WP_001037799.1 | carbohydrate porin | - |
| HB638_RS23690 () | 63674..65107 | - | 1434 | WP_024170639.1 | glycoside hydrolase family 32 protein | - |
| HB638_RS23695 () | 65104..66381 | - | 1278 | WP_001083369.1 | MFS transporter | - |
| HB638_RS23700 () | 66444..68570 | - | 2127 | WP_000253905.1 | alpha-galactosidase | - |
| HB638_RS23705 () | 68666..69676 | - | 1011 | WP_000053332.1 | substrate-binding domain-containing protein | - |
| HB638_RS23710 () | 69834..70592 | - | 759 | Protein_78 | site-specific integrase | - |
| HB638_RS23715 () | 70683..71911 | + | 1229 | WP_152924612.1 | IS3 family transposase | - |
| HB638_RS23720 () | 71896..72465 | + | 570 | WP_089634947.1 | hypothetical protein | - |
| HB638_RS24110 () | 73566..73800 | - | 235 | Protein_81 | hypothetical protein | - |
| HB638_RS23730 () | 73826..74389 | - | 564 | WP_029702196.1 | class I SAM-dependent methyltransferase | - |
| HB638_RS23735 () | 74437..75798 | - | 1362 | WP_039023242.1 | DUF3560 domain-containing protein | - |
| HB638_RS23740 () | 75850..76080 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| HB638_RS23745 () | 76597..76845 | + | 249 | WP_071781657.1 | hypothetical protein | - |
| HB638_RS23750 () | 77117..77308 | - | 192 | WP_001027495.1 | hypothetical protein | - |
| HB638_RS23755 () | 77305..77727 | - | 423 | WP_000271685.1 | DUF1380 family protein | - |
| HB638_RS23760 () | 77774..78076 | - | 303 | WP_001666994.1 | antirestriction protein | - |
| HB638_RS23775 () | 78613..79383 | - | 771 | WP_001006251.1 | hypothetical protein | - |
| HB638_RS23780 () | 79428..79862 | - | 435 | WP_001546462.1 | DUF1380 family protein | - |
| HB638_RS23785 () | 79876..80097 | - | 222 | WP_001104873.1 | hypothetical protein | - |
| HB638_RS23790 () | 80098..80781 | - | 684 | WP_032181561.1 | DNA methylase | - |
| HB638_RS23795 () | 80858..81162 | - | 305 | Protein_93 | hypothetical protein | - |
| HB638_RS23800 () | 81166..82068 | - | 903 | WP_064766247.1 | DUF1281 domain-containing protein | - |
| HB638_RS23805 () | 82806..83777 | - | 972 | WP_000817031.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| HB638_RS23810 () | 83777..84943 | - | 1167 | WP_000772446.1 | plasmid-partitioning protein SopA | - |
| HB638_RS23815 () | 85531..86286 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| HB638_RS23820 () | 87008..87814 | - | 807 | WP_000016970.1 | site-specific integrase | - |
| HB638_RS23825 () | 87815..88120 | - | 306 | WP_001159871.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| HB638_RS23830 () | 88122..88340 | - | 219 | WP_000813630.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| HB638_RS23835 () | 88900..89130 | + | 231 | WP_001261286.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin Detail |
| HB638_RS23840 () | 89127..89543 | + | 417 | WP_001034044.1 | type II toxin-antitoxin system VapC family toxin | Toxin Detail |
| HB638_RS23845 () | 89618..91183 | + | 1566 | WP_001128474.1 | AAA family ATPase | - |
| HB638_RS23850 () | 91168..92190 | + | 1023 | WP_000361402.1 | helicase UvrD | - |
| HB638_RS23855 () | 92444..93130 | - | 687 | Protein_105 | IS1 family transposase | - |
| HB638_RS23860 () | 93280..93977 | - | 698 | Protein_106 | IS1 family transposase | - |
| HB638_RS24115 () | 94177..94290 | + | 114 | Protein_107 | IS6 family transposase | - |
| HB638_RS23865 () | 94440..94598 | + | 159 | WP_000449408.1 | DsbA family protein | - |
| HB638_RS23870 () | 94588..95094 | + | 507 | WP_000949452.1 | protein disulfide oxidoreductase | - |
| HB638_RS23875 () | 95277..96092 | + | 816 | WP_012372823.1 | Na(+)-translocating NADH-quinone reductase subunit C | - |
| HB638_RS23880 () | 96439..98325 | + | 1887 | WP_000118029.1 | FTR1 family iron permease | - |
| HB638_RS23885 () | 98366..98893 | + | 528 | WP_000178050.1 | iron transporter | - |
| HB638_RS23890 () | 98997..100376 | + | 1380 | WP_000119836.1 | DUF2318 domain-containing protein | - |
| HB638_RS23895 () | 100379..101662 | + | 1284 | WP_000964653.1 | ABC transporter permease | - |
| HB638_RS23900 () | 101652..102782 | + | 1131 | WP_000729219.1 | ABC transporter permease | - |
| HB638_RS23905 () | 102787..103482 | + | 696 | WP_000117262.1 | ABC transporter ATP-binding protein | - |
| HB638_RS23910 () | 103469..103954 | + | 486 | WP_001267176.1 | TlpA family protein disulfide reductase | - |
| HB638_RS23915 () | 103979..104464 | + | 486 | WP_000874189.1 | hypothetical protein | - |
| HB638_RS23920 () | 104586..105218 | + | 633 | Protein_119 | histidine-type phosphatase | - |
| HB638_RS23925 () | 105368..105472 | - | 105 | Protein_120 | IS5/IS1182 family transposase | - |
| HB638_RS23930 () | 105506..107920 | - | 2415 | Protein_121 | Tn3 family transposase | - |
| HB638_RS23935 () | 107978..108682 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HB638_RS23940 () | 108804..109718 | + | 915 | WP_023063803.1 | Mph(A) family macrolide 2'-phosphotransferase | - |
| HB638_RS23945 () | 109715..110953 | + | 1239 | WP_000004159.1 | MFS transporter | - |
| HB638_RS23950 () | 110953..111537 | + | 585 | WP_001137892.1 | TetR family transcriptional regulator | - |
| HB638_RS23955 () | 112030..112794 | - | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| HB638_RS23960 () | 112901..113605 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HB638_RS23965 () | 113770..114063 | + | 294 | Protein_128 | IS30 family transposase | - |
| HB638_RS23970 () | 114164..114976 | + | 813 | WP_023408309.1 | subclass B1 metallo-beta-lactamase NDM-5 | - |
| HB638_RS23975 () | 114980..115345 | + | 366 | WP_004201167.1 | bleomycin binding protein Ble-MBL | - |
| HB638_RS23980 () | 115350..115988 | + | 639 | WP_004201168.1 | phosphoribosylanthranilate isomerase | - |
| HB638_RS23985 () | 115999..117030 | - | 1032 | WP_004201169.1 | protein-disulfide reductase DsbD N-terminal domain-containing protein | - |
| HB638_RS23990 () | 117343..118884 | - | 1542 | WP_000050481.1 | IS91 family transposase | - |
| HB638_RS23995 () | 119289..120128 | - | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
| HB638_RS24000 () | 120122..120469 | - | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
| HB638_RS24005 () | 120633..121424 | - | 792 | WP_001206356.1 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2 | - |
| HB638_RS24010 () | 121430..121720 | - | 291 | WP_001336345.1 | DUF1010 domain-containing protein | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|