MGE detailed information
MGE type: Conjugative plasmid MGE length: 151747 bp
Accession: NZ_CP035468 Location: 1..151747 Organism: Escherichia coli strain U12A Replicon: plasmid pU12A_A
Accession: NZ_CP035468 Location: 1..151747 Organism: Escherichia coli strain U12A Replicon: plasmid pU12A_A
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| U12A_RS00010 () | 49..1359 | - | 1311 | WP_001262765.1 | DUF262 domain-containing protein | - |
| U12A_RS00015 () | 1644..2045 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| U12A_RS00020 () | 1978..2235 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| U12A_RS00025 () | 2328..2981 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| U12A_RS00035 () | 3921..4778 | - | 858 | WP_001617855.1 | incFII family plasmid replication initiator RepA | - |
| U12A_RS00040 () | 4771..4845 | - | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| U12A_RS27650 () | 4842..4976 | - | 135 | Protein_7 | protein CopA/IncA | - |
| U12A_RS00050 () | 5082..5336 | - | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| U12A_RS00055 () | 5633..5767 | - | 135 | WP_023144756.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 5812..5872 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 5812..5872 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 5812..5872 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 5812..5872 | + | 61 | NuclAT_2 | - | Antitoxin Detail |
| U12A_RS27465 () | 5839..6125 | - | 287 | Protein_10 | DUF2726 domain-containing protein | - |
| U12A_RS00065 () | 6203..7816 | - | 1614 | WP_000080195.1 | IS66-like element ISEc23 family transposase | - |
| U12A_RS00070 () | 7847..8197 | - | 351 | WP_000624722.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| U12A_RS00075 () | 8194..8619 | - | 426 | WP_000422741.1 | IS66 family insertion sequence hypothetical protein | - |
| U12A_RS00085 () | 9178..9390 | - | 213 | WP_013023861.1 | hypothetical protein | - |
| U12A_RS00090 () | 9521..10081 | - | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| U12A_RS00095 () | 10136..10882 | - | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
| U12A_RS00100 () | 10902..16172 | - | 5271 | WP_001617867.1 | conjugative transfer relaxase/helicase TraI | - |
| U12A_RS00105 () | 16172..18370 | - | 2199 | WP_024623315.1 | type IV conjugative transfer system coupling protein TraD | - |
| U12A_RS00110 () | 18367..19146 | - | 780 | WP_000199914.1 | hypothetical protein | - |
| U12A_RS00115 () | 19349..20080 | - | 732 | WP_000850429.1 | complement resistance protein TraT | - |
| U12A_RS00120 () | 20112..20609 | - | 498 | WP_000605862.1 | entry exclusion protein | - |
| U12A_RS00125 () | 20628..23447 | - | 2820 | WP_001007062.1 | conjugal transfer mating pair stabilization protein TraG | - |
| U12A_RS00130 () | 23444..24817 | - | 1374 | WP_000944328.1 | conjugal transfer protein TraH | - |
| U12A_RS00135 () | 24804..25229 | - | 426 | WP_001348758.1 | F-type conjugal transfer protein TrbF | - |
| U12A_RS00140 () | 25177..25524 | - | 348 | WP_071571857.1 | P-type conjugative transfer protein TrbJ | - |
| U12A_RS00145 () | 25454..25999 | - | 546 | WP_000059829.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| U12A_RS00150 () | 25986..26270 | - | 285 | WP_001617873.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| U12A_RS00155 () | 26397..26717 | - | 321 | WP_001348757.1 | conjugal transfer protein TrbA | - |
| U12A_RS00160 () | 26765..27462 | - | 698 | Protein_29 | IS1 family transposase | - |
| U12A_RS00165 () | 27617..28597 | - | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
| U12A_RS00170 () | 28727..29470 | - | 744 | WP_001030401.1 | type-F conjugative transfer system pilin assembly protein TraF | - |
| U12A_RS00175 () | 29463..29720 | - | 258 | WP_000864347.1 | conjugal transfer protein TrbE | - |
| U12A_RS00180 () | 29747..31597 | - | 1851 | WP_000821866.1 | type-F conjugative transfer system mating-pair stabilization protein TraN | - |
| U12A_RS00185 () | 31594..32232 | - | 639 | WP_001080259.1 | type-F conjugative transfer system pilin assembly protein TrbC | - |
| U12A_RS00190 () | 32241..32546 | - | 306 | WP_000224413.1 | hypothetical protein | - |
| U12A_RS00195 () | 32576..33568 | - | 993 | WP_000830190.1 | conjugal transfer pilus assembly protein TraU | - |
| U12A_RS00200 () | 33565..34197 | - | 633 | WP_001203727.1 | type-F conjugative transfer system protein TraW | - |
| U12A_RS00205 () | 34194..34580 | - | 387 | WP_000214084.1 | type-F conjugative transfer system protein TrbI | - |
| U12A_RS00210 () | 34577..37204 | - | 2628 | WP_001064258.1 | type IV secretion system protein TraC | - |
| U12A_RS00215 () | 37364..37585 | - | 222 | WP_001278694.1 | conjugal transfer protein TraR | - |
| U12A_RS00220 () | 37720..38235 | - | 516 | WP_000809886.1 | type IV conjugative transfer system lipoprotein TraV | - |
| U12A_RS00225 () | 38235..38594 | - | 360 | WP_001617876.1 | conjugal transfer protein TrbD | - |
| U12A_RS00230 () | 38533..39120 | - | 588 | WP_013023871.1 | conjugal transfer protein TraP | - |
| U12A_RS00235 () | 39089..40540 | - | 1452 | WP_000146687.1 | conjugal transfer protein TraB | - |
| U12A_RS00240 () | 40540..41244 | - | 705 | WP_148725207.1 | type-F conjugative transfer system secretin TraK | - |
| U12A_RS00245 () | 41255..41821 | - | 567 | WP_000399791.1 | type IV conjugative transfer system protein TraE | - |
| U12A_RS00250 () | 41843..42154 | - | 312 | WP_000012107.1 | type IV conjugative transfer system protein TraL | - |
| U12A_RS00255 () | 42159..42521 | - | 363 | WP_000338606.1 | type IV conjugative transfer system pilin TraA | - |
| U12A_RS00260 () | 42555..42782 | - | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
| U12A_RS00265 () | 42870..43547 | - | 678 | WP_001348626.1 | PAS domain-containing protein | - |
| U12A_RS00270 () | 43681..44064 | - | 384 | WP_001151566.1 | relaxosome protein TraM | - |
| U12A_RS00275 () | 44395..44997 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| U12A_RS00280 () | 45294..46115 | - | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
| U12A_RS00285 () | 46234..46521 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| U12A_RS27655 () | 46546..46752 | - | 207 | WP_000275859.1 | hypothetical protein | - |
| U12A_RS27660 () | 46665..47000 | - | 336 | WP_013023876.1 | hypothetical protein | - |
| U12A_RS00305 () | 47443..47601 | - | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| - () | 47645..47685 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 47645..47685 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 47645..47685 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 47645..47685 | - | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 49129..49315 | - | 187 | NuclAT_0 | - | - |
| - () | 49129..49315 | - | 187 | NuclAT_0 | - | - |
| - () | 49129..49315 | - | 187 | NuclAT_0 | - | - |
| - () | 49129..49315 | - | 187 | NuclAT_0 | - | - |
| U12A_RS00315 () | 49327..50046 | - | 720 | WP_001276232.1 | plasmid SOS inhibition protein A | - |
| U12A_RS00320 () | 50043..50477 | - | 435 | WP_000845940.1 | conjugation system SOS inhibitor PsiB | - |
| U12A_RS00325 () | 50532..52490 | - | 1959 | WP_129765214.1 | ParB/RepB/Spo0J family partition protein | - |
| U12A_RS00330 () | 52556..52789 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| U12A_RS00335 () | 52852..53391 | - | 540 | WP_000290841.1 | single-stranded DNA-binding protein | - |
| U12A_RS27665 () | 53536..53871 | - | 336 | WP_013023883.1 | hypothetical protein | - |
| U12A_RS00360 () | 54034..54270 | - | 237 | WP_032153960.1 | hypothetical protein | - |
| U12A_RS00365 () | 54296..54859 | - | 564 | WP_001348621.1 | class I SAM-dependent methyltransferase | - |
| U12A_RS00370 () | 54907..56268 | - | 1362 | WP_000170714.1 | DUF3560 domain-containing protein | - |
| U12A_RS00375 () | 56320..56550 | - | 231 | WP_000218642.1 | hypothetical protein | - |
| U12A_RS00385 () | 57585..57776 | - | 192 | WP_001027516.1 | hypothetical protein | - |
| U12A_RS00390 () | 57773..58195 | - | 423 | WP_000271753.1 | DUF1380 family protein | - |
| U12A_RS00395 () | 58242..58544 | - | 303 | WP_001671341.1 | antirestriction protein | - |
| U12A_RS00405 () | 59084..59860 | - | 777 | WP_001753849.1 | hypothetical protein | - |
| U12A_RS00410 () | 59906..60340 | - | 435 | WP_000274437.1 | DUF1380 family protein | - |
| U12A_RS00415 () | 60354..60575 | - | 222 | WP_001104873.1 | hypothetical protein | - |
| U12A_RS00420 () | 60576..61259 | - | 684 | WP_000086185.1 | DNA methylase | - |
| U12A_RS00425 () | 61336..61640 | - | 305 | Protein_76 | hypothetical protein | - |
| U12A_RS00430 () | 61644..62546 | - | 903 | WP_001348615.1 | DUF1281 domain-containing protein | - |
| U12A_RS00445 () | 63413..64384 | - | 972 | WP_000817036.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| U12A_RS00450 () | 64384..65550 | - | 1167 | WP_000772446.1 | plasmid-partitioning protein SopA | - |
| U12A_RS00455 () | 66138..66893 | - | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| U12A_RS00460 () | 67667..68473 | - | 807 | WP_000016982.1 | site-specific integrase | - |
| U12A_RS00465 () | 68474..68779 | - | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| U12A_RS00470 () | 68781..68999 | - | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| U12A_RS00475 () | 69707..70702 | + | 996 | WP_000246636.1 | hypothetical protein | - |
| U12A_RS00480 () | 70706..71638 | + | 933 | WP_000991832.1 | hypothetical protein | - |
| U12A_RS00485 () | 71775..72472 | - | 698 | Protein_86 | IS1 family transposase | - |
| U12A_RS00490 () | 72686..75802 | - | 3117 | WP_001553854.1 | HsdR family type I site-specific deoxyribonuclease | - |
| U12A_RS00495 () | 75924..77207 | - | 1284 | WP_001617890.1 | restriction endonuclease subunit S | - |
| U12A_RS00500 () | 77204..78760 | - | 1557 | WP_001617892.1 | type I restriction-modification system subunit M | - |
| U12A_RS00505 () | 78943..79164 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin Detail |
| U12A_RS00510 () | 79164..79544 | + | 381 | WP_001216034.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin Detail |
| U12A_RS00515 () | 79549..79728 | + | 180 | WP_001513661.1 | hypothetical protein | - |
| U12A_RS00520 () | 79756..80115 | + | 360 | WP_001513660.1 | hypothetical protein | - |
| U12A_RS00525 () | 80039..80452 | + | 414 | Protein_94 | DDE-type integrase/transposase/recombinase | - |
| U12A_RS00530 () | 80402..80719 | - | 318 | WP_001513659.1 | hypothetical protein | - |
| U12A_RS00535 () | 80947..81927 | - | 981 | WP_000019407.1 | IS5-like element IS5 family transposase | - |
| U12A_RS00540 () | 82171..83574 | + | 1404 | WP_001373486.1 | S-methylmethionine permease | - |
| U12A_RS00545 () | 83561..84493 | + | 933 | WP_000081352.1 | homocysteine S-methyltransferase | - |
| U12A_RS00550 () | 84602..84931 | - | 330 | Protein_99 | TOBE domain-containing protein | - |
| U12A_RS00555 () | 84947..85644 | - | 698 | Protein_100 | IS1 family transposase | - |
| U12A_RS00560 () | 85702..85950 | + | 249 | Protein_101 | abortive infection family protein | - |
| U12A_RS00565 () | 86319..87050 | - | 732 | WP_001617898.1 | hypothetical protein | - |
| U12A_RS00575 () | 87836..88813 | + | 978 | WP_000361610.1 | RepB family plasmid replication initiator protein | - |
| U12A_RS00580 () | 89098..89838 | - | 741 | WP_001066941.1 | tyrosine-type recombinase/integrase | - |
| U12A_RS00585 () | 89959..90147 | - | 189 | WP_001309252.1 | hypothetical protein | - |
| U12A_RS00590 () | 90514..91683 | + | 1170 | WP_001072358.1 | hypothetical protein | - |
| U12A_RS00595 () | 91909..92084 | - | 176 | Protein_107 | IS3 family transposase | - |
| U12A_RS00600 () | 92530..92802 | - | 273 | WP_001322642.1 | adhesin biosynthesis transcription regulatory family protein | - |
| U12A_RS00605 () | 93327..93763 | - | 437 | Protein_109 | transposase | - |
| U12A_RS00610 () | 94045..96015 | + | 1971 | WP_001298664.1 | TonB-dependent hemoglobin/transferrin/lactoferrin family receptor | - |
| U12A_RS00615 () | 96022..96813 | + | 792 | WP_000977394.1 | DUF4198 domain-containing protein | - |
| U12A_RS00620 () | 96876..97484 | - | 609 | Protein_112 | IS66 family transposase | - |
| U12A_RS00625 () | 97552..98334 | - | 783 | WP_001300609.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| U12A_RS00630 () | 98331..99353 | - | 1023 | WP_001310017.1 | IS21-like element IS100 family transposase | - |
| U12A_RS00635 () | 99439..100384 | - | 946 | Protein_115 | IS66 family transposase | - |
| U12A_RS00640 () | 100433..100780 | - | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| U12A_RS00645 () | 100777..101181 | - | 405 | WP_000839179.1 | IS66 family insertion sequence hypothetical protein | - |
| U12A_RS00650 () | 101210..101593 | - | 384 | Protein_118 | DDE-type integrase/transposase/recombinase | - |
| U12A_RS00655 () | 101683..103191 | - | 1509 | WP_001189113.1 | group II intron reverse transcriptase/maturase | - |
| U12A_RS00665 () | 103864..104603 | - | 740 | Protein_120 | IS3 family transposase | - |
| U12A_RS00670 () | 104629..104934 | + | 306 | Protein_121 | IS91 family transposase | - |
| U12A_RS00675 () | 105457..106632 | - | 1176 | WP_001020413.1 | enterotoxin production-related protein TieB | - |
| U12A_RS00685 () | 106701..108962 | - | 2262 | WP_001100763.1 | TonB-dependent receptor | - |
| U12A_RS00690 () | 109131..109907 | - | 777 | WP_000981091.1 | energy transducer TonB | - |
| U12A_RS00695 () | 109915..110790 | - | 876 | WP_001224623.1 | ChaN family lipoprotein | - |
| U12A_RS00700 () | 111122..111669 | - | 548 | Protein_126 | primase alpha helix C-terminal domain-containing protein | - |
| U12A_RS00725 () | 113241..113576 | - | 336 | WP_001080732.1 | colicin transporter | - |
| U12A_RS00730 () | 113705..114052 | + | 348 | WP_000142452.1 | hypothetical protein | - |
| U12A_RS00735 () | 114072..114581 | - | 510 | WP_000194542.1 | hypothetical protein | - |
| U12A_RS00740 () | 114578..114838 | - | 261 | WP_000371882.1 | hypothetical protein | - |
| U12A_RS00745 () | 114940..115679 | + | 740 | Protein_131 | IS3 family transposase | - |
| U12A_RS27670 () | 116352..116666 | + | 315 | Protein_132 | hypothetical protein | - |
| U12A_RS27675 () | 116667..116840 | + | 174 | Protein_133 | transposase | - |
| U12A_RS00760 () | 116990..117623 | - | 634 | Protein_134 | histidine-type phosphatase | - |
| U12A_RS00765 () | 117745..118230 | - | 486 | WP_000874189.1 | hypothetical protein | - |
| U12A_RS00770 () | 118255..118740 | - | 486 | WP_001267176.1 | TlpA family protein disulfide reductase | - |
| U12A_RS00775 () | 118727..119422 | - | 696 | WP_000117262.1 | ABC transporter ATP-binding protein | - |
| U12A_RS00780 () | 119427..120557 | - | 1131 | WP_000729218.1 | ABC transporter permease | - |
| U12A_RS00785 () | 120547..121830 | - | 1284 | WP_000964653.1 | ABC transporter permease | - |
| U12A_RS00790 () | 121833..123212 | - | 1380 | WP_000119836.1 | DUF2318 domain-containing protein | - |
| U12A_RS00795 () | 123316..123843 | - | 528 | WP_000178050.1 | iron transporter | - |
| U12A_RS00800 () | 123884..125770 | - | 1887 | WP_000118029.1 | FTR1 family iron permease | - |
| U12A_RS00810 () | 126117..126932 | - | 816 | WP_012372823.1 | Na(+)-translocating NADH-quinone reductase subunit C | - |
| U12A_RS00815 () | 127115..127621 | - | 507 | WP_000949452.1 | protein disulfide oxidoreductase | - |
| U12A_RS00820 () | 127611..127769 | - | 159 | WP_000449408.1 | DsbA family protein | - |
| U12A_RS27680 () | 127919..128032 | - | 114 | Protein_146 | IS6 family transposase | - |
| U12A_RS00835 () | 128232..128905 | + | 674 | Protein_147 | IS1 family transposase | - |
| U12A_RS00840 () | 128958..129662 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| U12A_RS00845 () | 129721..130470 | - | 750 | Protein_149 | class 1 integron integrase IntI1 | - |
| U12A_RS00850 () | 130628..131101 | + | 474 | WP_001389366.1 | trimethoprim-resistant dihydrofolate reductase DfrA17 | - |
| U12A_RS00855 () | 131232..132020 | + | 789 | WP_000503573.1 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA5 | - |
| U12A_RS00860 () | 132226..132573 | + | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
| U12A_RS00865 () | 132567..133406 | + | 840 | WP_000259031.1 | sulfonamide-resistant dihydropteroate synthase Sul1 | - |
| U12A_RS00875 () | 133534..133737 | + | 204 | WP_000376616.1 | hypothetical protein | - |
| U12A_RS00880 () | 133893..135098 | + | 1206 | WP_000184001.1 | chromate efflux transporter | - |
| U12A_RS00885 () | 135109..135414 | + | 306 | WP_000130000.1 | PadR family transcriptional regulator | - |
| U12A_RS27470 () | 135458..135523 | + | 66 | Protein_157 | EAL domain-containing protein | - |
| U12A_RS00895 () | 135641..136405 | + | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| U12A_RS00910 () | 136898..137482 | - | 585 | WP_001137892.1 | TetR family transcriptional regulator | - |
| U12A_RS00915 () | 137482..138720 | - | 1239 | WP_000004159.1 | MFS transporter | - |
| U12A_RS00920 () | 138717..139622 | - | 906 | WP_000219391.1 | Mph(A) family macrolide 2'-phosphotransferase | - |
| U12A_RS00930 () | 139744..140448 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| U12A_RS00935 () | 140509..140685 | + | 177 | Protein_163 | replication protein C | - |
| U12A_RS00945 () | 140993..141808 | + | 816 | WP_001043260.1 | sulfonamide-resistant dihydropteroate synthase Sul2 | - |
| U12A_RS00950 () | 141869..142672 | + | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
| U12A_RS00955 () | 142672..143508 | + | 837 | WP_000480972.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
| U12A_RS00960 () | 143562..143798 | + | 237 | WP_042005022.1 | hypothetical protein | - |
| U12A_RS00965 () | 143830..144456 | - | 627 | WP_031606906.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| U12A_RS00970 () | 144562..145761 | + | 1200 | WP_000804064.1 | tetracycline efflux MFS transporter Tet(A) | - |
| U12A_RS00975 () | 145793..146653 | - | 861 | WP_000493383.1 | EamA family transporter | - |
| U12A_RS00980 () | 146662..147168 | - | 507 | Protein_171 | transposase | - |
| U12A_RS00990 () | 147221..147925 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| U12A_RS00995 () | 147990..148484 | - | 495 | Protein_173 | IS4-like element ISVsa5 family transposase | - |
| U12A_RS01005 () | 148627..149487 | + | 861 | WP_000557454.1 | aminoglycoside N-acetyltransferase AAC(3)-IId | - |
| U12A_RS27685 () | 149500..149604 | + | 105 | Protein_175 | tunicamycin resistance protein | - |
| U12A_RS01015 () | 149656..150360 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| U12A_RS01020 () | 150659..151519 | + | 861 | WP_000027057.1 | class A broad-spectrum beta-lactamase TEM-1 | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|