MGE detailed information
MGE type: Integrative_Conjugative_Elements MGE length: 172735 bp
Accession: NZ_CP035438 Location: 154659..327393 Organism: Streptococcus pyogenes strain emm22.8 Replicon: chromosome
Accession: NZ_CP035438 Location: 154659..327393 Organism: Streptococcus pyogenes strain emm22.8 Replicon: chromosome
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ETT61_RS00920 () | 149815..150135 | + | 321 | WP_002986440.1 | hypothetical protein | - |
| ETT61_RS00925 () | 150125..152125 | + | 2001 | WP_136020283.1 | V-type ATP synthase subunit I | - |
| ETT61_RS00930 () | 152127..152606 | + | 480 | WP_002993834.1 | V-type ATP synthase subunit K | - |
| ETT61_RS00935 () | 152675..153259 | + | 585 | WP_136020284.1 | ATPase V | - |
| ETT61_RS00940 () | 153275..154273 | + | 999 | WP_136020285.1 | V-type ATPase subunit | - |
| ETT61_RS00945 () | 154270..154590 | + | 321 | WP_002987866.1 | V-type ATP synthase subunit F | - |
| ETT61_RS00950 () | 154791..156566 | + | 1776 | WP_136020286.1 | V-type sodium ATPase catalytic subunit A | VF |
| ETT61_RS00955 () | 156567..157982 | + | 1416 | WP_136020287.1 | V-type sodium ATPase subunit B | VF |
| ETT61_RS00960 () | 158027..158653 | + | 627 | WP_002986417.1 | V-type ATP synthase subunit D | - |
| ETT61_RS00965 () | 158773..160035 | - | 1263 | WP_136020288.1 | toxic anion resistance protein | - |
| ETT61_RS00970 () | 160048..160926 | - | 879 | WP_014635244.1 | hypothetical protein | - |
| ETT61_RS00975 () | 161364..162656 | + | 1293 | WP_136020289.1 | adenylosuccinate synthase | - |
| ETT61_RS00980 () | 162983..164026 | + | 1044 | WP_168389633.1 | BMP family protein | - |
| ETT61_RS00985 () | 164200..164739 | + | 540 | WP_002987881.1 | transcription termination/antitermination protein NusG | - |
| ETT61_RS00990 () | 165111..166466 | + | 1356 | WP_014407249.1 | nicotine adenine dinucleotide glycohydrolase | - |
| ETT61_RS00995 () | 166471..166956 | + | 486 | WP_009880983.1 | NAD glycohydrolase inhibitor | - |
| ETT61_RS01000 () | 166980..168695 | + | 1716 | WP_136020290.1 | Streptolysin O | VF |
| ETT61_RS01005 () | 168950..169360 | + | 411 | WP_136020291.1 | TrbC/VirB2 family protein | - |
| ETT61_RS01010 () | 169547..169783 | - | 237 | WP_136020292.1 | hypothetical protein | - |
| ETT61_RS01015 () | 170184..170351 | - | 168 | WP_011284460.1 | hypothetical protein | - |
| ETT61_RS01020 () | 170545..170817 | - | 273 | WP_136020293.1 | hypothetical protein | - |
| ETT61_RS01025 () | 171301..172440 | + | 1140 | WP_136020302.1 | PLP-dependent aspartate aminotransferase family protein | - |
| ETT61_RS01030 () | 172652..175153 | + | 2502 | WP_136020294.1 | leucine--tRNA ligase | - |
| ETT61_RS01035 () | 175460..176893 | + | 1434 | WP_032464661.1 | PTS sugar transporter subunit IIC | - |
| ETT61_RS01040 () | 176964..177242 | + | 279 | WP_002986367.1 | PTS sugar transporter subunit IIB | - |
| ETT61_RS01045 () | 177365..177850 | + | 486 | WP_030126936.1 | PTS sugar transporter subunit IIA | - |
| ETT61_RS01050 () | 177941..178603 | + | 663 | WP_002992542.1 | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD | - |
| ETT61_RS01055 () | 178608..179471 | + | 864 | WP_002992543.1 | L-ribulose-5-phosphate 3-epimerase | - |
| ETT61_RS01060 () | 179473..180177 | + | 705 | WP_053308168.1 | L-ribulose-5-phosphate 4-epimerase | - |
| ETT61_RS01070 () | 180502..182148 | + | 1647 | WP_168389634.1 | transcription antiterminator | - |
| ETT61_RS01075 () | 182401..183492 | + | 1092 | WP_002986347.1 | L-ascorbate 6-phosphate lactonase | - |
| ETT61_RS01080 () | 183981..185177 | + | 1197 | WP_002986345.1 | Glycine betaine transport ATP-binding protein OpuAA | VF |
| ETT61_RS01085 () | 185193..186920 | + | 1728 | WP_136020295.1 | ABC transporter permease/substrate binding protein | - |
| ETT61_RS01090 () | 187051..189693 | + | 2643 | WP_136020296.1 | DNA polymerase I | - |
| ETT61_RS01095 () | 189871..190326 | + | 456 | WP_002986334.1 | CoA-binding protein | - |
| ETT61_RS01100 () | 190378..190845 | + | 468 | WP_002986328.1 | peroxide-responsive transcriptional repressor PerR | - |
| ETT61_RS01105 () | 191002..191301 | + | 300 | WP_009880534.1 | hypothetical protein | - |
| ETT61_RS01110 () | 191523..192857 | + | 1335 | WP_031488638.1 | phosphoadenosine phosphosulfate reductase | - |
| ETT61_RS01115 () | 192850..193380 | + | 531 | WP_136020297.1 | ParB/RepB/Spo0J family partition protein | - |
| ETT61_RS10050 () | 193427..193582 | - | 156 | Protein_168 | ISL3 family transposase | - |
| ETT61_RS01125 () | 193708..194874 | - | 1167 | Protein_169 | IS3 family transposase | - |
| ETT61_RS01135 () | 194952..196262 | - | 1311 | WP_014407266.1 | C4-dicarboxylate ABC transporter | - |
| ETT61_RS01140 () | 196486..197358 | + | 873 | WP_002992869.1 | carboxylating nicotinate-nucleotide diphosphorylase | - |
| ETT61_RS01145 () | 197621..198520 | - | 900 | Protein_172 | IS3 family transposase ISStin7 | Transposase |
| ETT61_RS01150 () | 198606..199469 | - | 864 | WP_014407270.1 | DUF975 family protein | - |
| ETT61_RS01160 () | 199688..200830 | + | 1143 | WP_011528208.1 | tRNA guanosine(34) transglycosylase Tgt | - |
| ETT61_RS01165 () | 201047..201358 | + | 312 | WP_002987947.1 | hypothetical protein | - |
| ETT61_RS01170 () | 201362..201901 | + | 540 | WP_002986314.1 | biotin transporter BioY | - |
| ETT61_RS01175 () | 202040..202819 | + | 780 | WP_011528209.1 | MBL fold metallo-hydrolase | - |
| ETT61_RS01180 () | 202819..203334 | + | 516 | WP_002992549.1 | tRNA adenosine(34) deaminase TadA | - |
| ETT61_RS01185 () | 203948..205180 | - | 1233 | WP_136020525.1 | S-layer protein | - |
| ETT61_RS01195 () | 205580..206284 | + | 705 | WP_010921857.1 | Exotoxin type C | VF |
| ETT61_RS01200 () | 206740..208089 | + | 1350 | WP_014635263.1 | glucose-6-phosphate isomerase | - |
| ETT61_RS01205 () | 208438..209946 | - | 1509 | WP_002986134.1 | helix-turn-helix domain-containing protein | - |
| ETT61_RS01210 () | 210501..211633 | + | 1133 | Protein_183 | ISAs1 family transposase IS1548 | Transposase |
| ETT61_RS10055 () | 211617..211811 | + | 195 | WP_168389637.1 | exfoliative toxin | - |
| ETT61_RS01220 () | 211959..212630 | + | 672 | WP_136020304.1 | rhomboid family intramembrane serine protease | - |
| ETT61_RS01225 () | 212730..213629 | - | 900 | WP_136020305.1 | UTP--glucose-1-phosphate uridylyltransferase | VF |
| ETT61_RS01230 () | 213662..214678 | - | 1017 | WP_002986123.1 | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase | - |
| ETT61_RS01235 () | 214974..215423 | + | 450 | WP_002986120.1 | MarR family transcriptional regulator | - |
| ETT61_RS01240 () | 215416..217122 | + | 1707 | WP_136020306.1 | ABC transporter ATP-binding protein/permease | - |
| ETT61_RS01245 () | 217125..218909 | + | 1785 | WP_002986115.1 | putative ABC transporter ATP-binding protein | VF |
| ETT61_RS01250 () | 219027..219794 | + | 768 | WP_011054158.1 | epoxyqueuosine reductase QueH | - |
| ETT61_RS01255 () | 219904..220350 | + | 447 | WP_002986111.1 | dUTP diphosphatase | - |
| ETT61_RS01260 () | 220431..221792 | + | 1362 | WP_136020307.1 | DNA repair protein RadA | - |
| ETT61_RS01265 () | 221981..222478 | + | 498 | WP_010921867.1 | carbonic anhydrase | - |
| ETT61_RS01270 () | 222609..223319 | + | 711 | WP_168389638.1 | TIGR00266 family protein | - |
| ETT61_RS01275 () | 223501..224946 | + | 1446 | WP_032460440.1 | glutamate--tRNA ligase | - |
| ETT61_RS01280 () | 225340..226686 | + | 1347 | WP_136020308.1 | sensor histidine kinase | - |
| ETT61_RS01285 () | 226683..227966 | + | 1284 | WP_014407281.1 | sensor histidine kinase | - |
| ETT61_RS01290 () | 227970..228710 | + | 741 | WP_002986100.1 | Accessory gene regulator A | VF |
| ETT61_RS01295 () | 229250..229609 | + | 360 | WP_002992035.1 | ribonuclease P protein component | - |
| ETT61_RS01300 () | 229575..230402 | + | 828 | WP_136020309.1 | YidC/Oxa1 family membrane protein insertase | - |
| ETT61_RS01305 () | 230414..231328 | + | 915 | WP_136020310.1 | protein jag | - |
| ETT61_RS01310 () | 231636..231830 | + | 195 | WP_070031335.1 | hypothetical protein | - |
| ETT61_RS01315 () | 231830..232804 | + | 975 | WP_074626861.1 | replication initiator protein A | - |
| ETT61_RS10060 () | 232797..232955 | + | 159 | WP_014295382.1 | hypothetical protein | - |
| ETT61_RS01320 () | 233195..233521 | + | 327 | WP_094983377.1 | hypothetical protein | - |
| ETT61_RS01325 () | 233532..234311 | + | 780 | WP_136020311.1 | hypothetical protein | VF |
| ETT61_RS01330 () | 234393..238928 | + | 4536 | WP_136020312.1 | Cell surface antigen I/II | VF |
| ETT61_RS01335 () | 239135..239362 | + | 228 | WP_000379152.1 | hypothetical protein | - |
| ETT61_RS01340 () | 239442..239999 | + | 558 | WP_094983374.1 | hypothetical protein | - |
| ETT61_RS01345 () | 240058..240807 | + | 750 | WP_094983373.1 | hypothetical protein | - |
| ETT61_RS01350 () | 240861..241217 | + | 357 | WP_094983372.1 | PrgI family protein | - |
| ETT61_RS01355 () | 241192..243552 | + | 2361 | WP_094983371.1 | DUF87 domain-containing protein | - |
| ETT61_RS01360 () | 243589..246249 | + | 2661 | WP_136020313.1 | CHAP domain-containing protein | - |
| ETT61_RS01365 () | 246266..246871 | + | 606 | WP_000564600.1 | hypothetical protein | - |
| ETT61_RS01370 () | 246883..247269 | + | 387 | WP_094983369.1 | single-stranded DNA-binding protein | - |
| ETT61_RS01375 () | 247285..247560 | + | 276 | WP_074626871.1 | hypothetical protein | - |
| ETT61_RS01380 () | 247560..248363 | + | 804 | WP_094983368.1 | hypothetical protein | - |
| ETT61_RS01385 () | 248381..248872 | + | 492 | WP_136020314.1 | DUF3801 domain-containing protein | - |
| ETT61_RS01390 () | 248872..250938 | + | 2067 | WP_094983366.1 | type IV secretory system conjugative DNA transfer family protein | - |
| ETT61_RS10065 () | 250974..251117 | + | 144 | WP_015695733.1 | hypothetical protein | - |
| ETT61_RS01395 () | 251172..252908 | + | 1737 | WP_094983365.1 | DNA topoisomerase III | - |
| ETT61_RS01400 () | 252957..257594 | + | 4638 | WP_136020315.1 | toprim domain-containing protein | - |
| ETT61_RS01405 () | 257652..257951 | + | 300 | WP_014295361.1 | hypothetical protein | - |
| ETT61_RS01415 () | 258259..258633 | + | 375 | WP_094983363.1 | plasmid mobilization relaxosome protein MobC | - |
| ETT61_RS01420 () | 258605..260233 | + | 1629 | WP_136020316.1 | relaxase/mobilization nuclease domain-containing protein | - |
| ETT61_RS01425 () | 260297..260479 | + | 183 | WP_094983362.1 | type II toxin-antitoxin system HicA family toxin | Toxin Detail |
| ETT61_RS01430 () | 260522..260974 | + | 453 | WP_094983361.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin Detail |
| ETT61_RS01440 () | 261166..262359 | - | 1194 | WP_136020317.1 | Transposase from transposon Tn916 ; Integrase | Integrase |
| ETT61_RS01445 () | 262438..262641 | - | 204 | WP_002610247.1 | excisionase | - |
| ETT61_RS01450 () | 262641..263732 | - | 1092 | WP_168389641.1 | replication initiation factor domain-containing protein | - |
| ETT61_RS01455 () | 264199..264870 | + | 672 | WP_002322214.1 | helix-turn-helix domain-containing protein | - |
| ETT61_RS01465 () | 265181..265660 | + | 480 | WP_002322212.1 | MGMT family protein | - |
| ETT61_RS01470 () | 265968..266462 | + | 495 | WP_002322211.1 | trimethoprim-resistant dihydrofolate reductase DfrF | - |
| ETT61_RS01475 () | 266551..266871 | + | 321 | WP_004611573.1 | hypothetical protein | - |
| ETT61_RS01485 () | 267294..267485 | + | 192 | WP_094983360.1 | type II toxin-antitoxin system HicA family toxin | - |
| ETT61_RS01490 () | 267553..267939 | + | 387 | WP_094983359.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| ETT61_RS10070 () | 268097..268267 | + | 171 | WP_000713595.1 | hypothetical protein | - |
| ETT61_RS01495 () | 268281..268883 | + | 603 | WP_001062586.1 | Tn3 family transposase TnpR_ISPa40 | Transposase |
| ETT61_RS01500 () | 268899..269576 | + | 678 | Protein_240 | DNA topoisomerase | - |
| ETT61_RS01505 () | 269887..270054 | + | 168 | WP_000898188.1 | hypothetical protein | - |
| ETT61_RS01510 () | 270088..270384 | + | 297 | WP_002360685.1 | hypothetical protein | - |
| ETT61_RS01515 () | 270385..270801 | + | 417 | WP_000323438.1 | hypothetical protein ; Integrase | Integrase |
| ETT61_RS01520 () | 270803..272365 | + | 1563 | WP_000136908.1 | Tn3 family transposase TnpR_Tn5403 | Transposase |
| ETT61_RS01525 () | 272508..272732 | + | 225 | WP_000205227.1 | helix-turn-helix transcriptional regulator | Antitoxin Detail |
| ETT61_RS01530 () | 272747..273616 | + | 870 | WP_000233000.1 | nucleotidyltransferase domain-containing protein | Toxin Detail |
| ETT61_RS01535 () | 273597..274331 | + | 735 | WP_000662263.1 | class I SAM-dependent methyltransferase | - |
| ETT61_RS01540 () | 274364..275272 | + | 909 | WP_001255866.1 | Aminoglycoside 6-adenylyltransferase | ARG |
| ETT61_RS01545 () | 275269..275749 | + | 481 | Protein_249 | GNAT family N-acetyltransferase | - |
| ETT61_RS01550 () | 275842..276636 | + | 795 | WP_001096887.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| ETT61_RS01555 () | 277046..277131 | + | 86 | Protein_251 | peptide-binding protein | - |
| ETT61_RS01560 () | 277180..277263 | + | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| ETT61_RS01565 () | 277388..278125 | + | 738 | WP_010725416.1 | rRNA adenine N-6-methyltransferase | ARG |
| ETT61_RS01575 () | 278295..278555 | + | 261 | Protein_254 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| ETT61_RS01580 () | 278631..279982 | + | 1352 | WP_136020319.1 | IS3 family transposase ISStin7 | Transposase |
| ETT61_RS10075 () | 280051..280362 | - | 312 | WP_153276871.1 | hypothetical protein | - |
| ETT61_RS01590 () | 281553..281618 | + | 66 | Protein_257 | type A chloramphenicol O-acetyltransferase | - |
| ETT61_RS01595 () | 282076..282726 | + | 651 | WP_039139170.1 | Chloramphenicol acetyltransferase | ARG |
| ETT61_RS01600 () | 282805..283104 | - | 300 | Protein_259 | TnsA endonuclease N-terminal domain-containing protein | - |
| ETT61_RS01605 () | 283159..283839 | - | 681 | WP_001015311.1 | IS6 family transposase IS1216E | Transposase |
| ETT61_RS01610 () | 284150..284317 | + | 168 | WP_002319681.1 | cysteine-rich KTR domain-containing protein | - |
| ETT61_RS01615 () | 284376..284729 | - | 354 | WP_002324548.1 | helix-turn-helix domain-containing protein | - |
| ETT61_RS01625 () | 285231..285656 | + | 426 | WP_002324547.1 | sigma-70 family RNA polymerase sigma factor | - |
| ETT61_RS01630 () | 285653..285883 | + | 231 | WP_002334012.1 | helix-turn-helix domain-containing protein | - |
| ETT61_RS01645 () | 286501..288102 | + | 1602 | WP_094983356.1 | IS607 family transposase ISCbt3 | Transposase |
| ETT61_RS01650 () | 288107..288427 | + | 321 | Protein_266 | cell filamentation protein Fic | - |
| ETT61_RS01655 () | 288579..289931 | + | 1353 | WP_094983355.1 | ISLre2 family transposase ISTeha1 | Transposase |
| ETT61_RS01660 () | 290359..290493 | + | 135 | WP_002885866.1 | 50S ribosomal protein L34 | - |
| ETT61_RS01665 () | 290766..291470 | + | 705 | WP_136020320.1 | N-acetylmannosamine-6-phosphate 2-epimerase | - |
| ETT61_RS01670 () | 291519..292838 | + | 1320 | WP_111704894.1 | ABC transporter substrate-binding protein | - |
| ETT61_RS01675 () | 292941..293828 | + | 888 | WP_087671307.1 | sugar ABC transporter permease | - |
| ETT61_RS01680 () | 293841..294671 | + | 831 | WP_009880516.1 | carbohydrate ABC transporter permease | - |
| ETT61_RS01685 () | 294828..295490 | + | 663 | WP_136020321.1 | DUF624 domain-containing protein | - |
| ETT61_RS01690 () | 295502..296416 | + | 915 | WP_136020322.1 | dihydrodipicolinate synthase family protein | - |
| ETT61_RS01695 () | 296438..297376 | + | 939 | WP_136020323.1 | ROK family protein | - |
| ETT61_RS01700 () | 297487..298317 | - | 831 | WP_023079304.1 | MurR/RpiR family transcriptional regulator | - |
| ETT61_RS01705 () | 298602..299393 | + | 792 | WP_168389640.1 | TatD family hydrolase | - |
| ETT61_RS01710 () | 299365..299955 | + | 591 | WP_011054172.1 | ribonuclease M5 | - |
| ETT61_RS01715 () | 300069..300941 | + | 873 | WP_002992056.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
| ETT61_RS01720 () | 301367..302239 | + | 873 | WP_032464165.1 | ribosome small subunit-dependent GTPase A | - |
| ETT61_RS01725 () | 302249..302911 | + | 663 | WP_002992061.1 | Ribulose-phosphate 3-epimerase | VF |
| ETT61_RS01730 () | 302904..303536 | + | 633 | WP_136020324.1 | thiamine diphosphokinase | - |
| ETT61_RS01735 () | 303538..304809 | + | 1272 | WP_136020325.1 | DNA recombination protein RmuC | - |
| ETT61_RS01740 () | 304799..305737 | + | 939 | WP_002991146.1 | 3'-5' exoribonuclease YhaM family protein | - |
| ETT61_RS01745 () | 306004..306843 | + | 840 | WP_002992072.1 | pur operon repressor | - |
| ETT61_RS01750 () | 306834..309455 | + | 2622 | WP_136020326.1 | SEC10/PgrA surface exclusion domain-containing protein | - |
| ETT61_RS01755 () | 309583..310715 | + | 1133 | Protein_287 | ISAs1 family transposase IS1548 | Transposase |
| ETT61_RS01765 () | 310988..311401 | + | 414 | WP_002986049.1 | 30S ribosomal protein S12 | - |
| ETT61_RS01770 () | 311422..311892 | + | 471 | WP_002992078.1 | 30S ribosomal protein S7 | - |
| ETT61_RS01780 () | 312259..314337 | + | 2079 | WP_002986045.1 | Elongation factor G | VF |
| ETT61_RS01785 () | 314685..315695 | + | 1011 | WP_002986042.1 | type I glyceraldehyde-3-phosphate dehydrogenase | - |
| ETT61_RS01790 () | 315921..316037 | - | 117 | WP_000818733.1 | putative metal homeostasis protein | - |
| ETT61_RS01795 () | 316179..316919 | - | 741 | WP_002991131.1 | Arginine transport ATP-binding protein ArtM | VF |
| ETT61_RS01800 () | 316912..318480 | - | 1569 | WP_136020502.1 | ABC transporter substrate-binding protein/permease | - |
| ETT61_RS01805 () | 318678..320603 | + | 1926 | WP_136020503.1 | DUF2207 domain-containing protein | - |
| ETT61_RS01810 () | 320669..321508 | + | 840 | WP_136020504.1 | undecaprenyl-diphosphate phosphatase | - |
| ETT61_RS01815 () | 321654..322415 | + | 762 | WP_002986029.1 | adaptor protein MecA | - |
| ETT61_RS01820 () | 322422..323591 | + | 1170 | WP_136020505.1 | undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase | - |
| ETT61_RS01825 () | 323714..324484 | + | 771 | WP_136020506.1 | Fe-S cluster assembly ATPase SufC | - |
| ETT61_RS01830 () | 324579..325841 | + | 1263 | WP_047235146.1 | Fe-S cluster assembly protein SufD | - |
| ETT61_RS01835 () | 325872..327098 | + | 1227 | WP_136020507.1 | cysteine desulfurase | - |
| ETT61_RS01840 () | 327085..327564 | + | 480 | WP_002986018.1 | SUF system NifU family Fe-S cluster assembly protein | - |
| ETT61_RS01845 () | 327557..328975 | + | 1419 | WP_136020508.1 | Fe-S cluster assembly protein SufB | - |
| ETT61_RS01850 () | 329127..330308 | - | 1182 | WP_136020509.1 | D-alanyl-D-alanine carboxypeptidase | - |
| ETT61_RS01855 () | 330476..331708 | - | 1233 | WP_111676124.1 | D-alanyl-D-alanine carboxypeptidase PBP3 | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|