Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 260297..260974 Replicon chromosome
Accession NZ_CP035438
Organism Streptococcus pyogenes strain emm22.8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag ETT61_RS01425 Protein ID WP_094983362.1
Coordinates 260297..260479 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ETT61_RS01430 Protein ID WP_094983361.1
Coordinates 260522..260974 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETT61_RS01405 257652..257951 + 300 WP_014295361.1 hypothetical protein -
ETT61_RS01415 258259..258633 + 375 WP_094983363.1 plasmid mobilization relaxosome protein MobC -
ETT61_RS01420 258605..260233 + 1629 WP_136020316.1 relaxase/mobilization nuclease domain-containing protein -
ETT61_RS01425 260297..260479 + 183 WP_094983362.1 type II toxin-antitoxin system HicA family toxin Toxin
ETT61_RS01430 260522..260974 + 453 WP_094983361.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ETT61_RS01440 261166..262359 - 1194 WP_136020317.1 site-specific integrase -
ETT61_RS01445 262438..262641 - 204 WP_002610247.1 excisionase -
ETT61_RS01450 262641..263732 - 1092 WP_168389641.1 replication initiation factor domain-containing protein -
ETT61_RS01455 264199..264870 + 672 WP_002322214.1 helix-turn-helix domain-containing protein -
ETT61_RS01465 265181..265660 + 480 WP_002322212.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / aph(3')-III / erm(B) / cat(pC194) slo / speG / hasC 154659..327393 172734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-73)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6680.94 Da        Isoelectric Point: 10.8936

>T117792 WP_094983362.1 NZ_CP035438:260297-260479 [Streptococcus pyogenes]
MPMTQKEMVKLLTAHGWKKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T117792 NZ_CP035438:260297-260479 [Streptococcus pyogenes]
ATGCCTATGACACAAAAAGAAATGGTTAAATTACTTACTGCCCATGGTTGGAAAAAAACTAAAGGCGGTAAGGGGTCACA
CGTTAAACTTGAAAAAGCTGGCGAACGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACTGAAAGGGGTATTA
AAAAGCAAGCAGGACTGTTATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16709.59 Da        Isoelectric Point: 3.8295

>AT117792 WP_094983361.1 NZ_CP035438:260522-260974 [Streptococcus pyogenes]
MLVTYPALFYYDDTDGSATPYFVTFPDFEYSATQGENMADAMTMASDWLGVTLADYIENGRDIPTPSSINTLSLIDNDPF
KNDDDFNLVYNPDKSFISMVVVDVAEYLGSQEPVKKTLTIPRWADTLGHELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT117792 NZ_CP035438:260522-260974 [Streptococcus pyogenes]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGATGATACTGACGGATCAGCTACACCATATTTTGTGACTTTTCCAGA
TTTTGAATATTCTGCAACACAAGGTGAGAACATGGCAGATGCCATGACTATGGCTAGTGATTGGCTAGGAGTTACTTTAG
CTGATTATATTGAAAATGGACGAGATATCCCTACTCCATCATCAATTAACACACTTTCTTTAATTGATAATGATCCATTT
AAGAATGATGACGATTTTAACTTAGTTTATAATCCTGATAAATCTTTTATCTCAATGGTTGTGGTTGATGTAGCTGAATA
CTTAGGAAGTCAGGAACCAGTCAAAAAAACACTGACTATTCCACGTTGGGCAGATACATTGGGTCATGAACTTGGATTGA
ATTTTTCACAAACTTTAACAGATGCTATCGCTGACAAAAAAATTCATGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References