MGE detailed information
MGE type: Conjugative plasmid MGE length: 134864 bp
Accession: NZ_AP022065 Location: 1..134864 Organism: Escherichia coli strain WP4-W18-ESBL-08 Replicon: plasmid pWP4-W18-ESBL-08_1
Accession: NZ_AP022065 Location: 1..134864 Organism: Escherichia coli strain WP4-W18-ESBL-08 Replicon: plasmid pWP4-W18-ESBL-08_1
Gene structure
The 5 kb flanking regions of this MGE are displayed.
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R03_RS23905 () | 999..1874 | + | 876 | WP_001224623.1 | ChaN family lipoprotein | - |
| H7R03_RS23910 () | 1882..2658 | + | 777 | WP_000981091.1 | energy transducer TonB | - |
| H7R03_RS23915 () | 2827..5088 | + | 2262 | WP_001100763.1 | TonB-dependent receptor | - |
| H7R03_RS23920 () | 5157..6332 | + | 1176 | WP_001020413.1 | putative protein YncE | VF |
| H7R03_RS23925 () | 6855..7160 | - | 306 | Protein_5 | IS91 family transposase ISSbo1 | Transposase |
| H7R03_RS23930 () | 7186..7925 | + | 740 | Protein_6 | IS3 family transposase IS629 | Transposase |
| H7R03_RS23935 () | 8598..10106 | + | 1509 | WP_001189113.1 | group II intron reverse transcriptase/maturase | - |
| H7R03_RS23940 () | 10196..10579 | + | 384 | Protein_8 | IS3 family transposase IS629 | Transposase |
| H7R03_RS23945 () | 10608..11012 | + | 405 | WP_000839179.1 | IS66 family transposase ISEc22 | Transposase |
| H7R03_RS23950 () | 11009..11356 | + | 348 | WP_000612626.1 | IS66 family transposase ISKpn24 | Transposase |
| H7R03_RS23955 () | 11405..12350 | + | 946 | Protein_11 | IS66 family transposase ISEc8 | Transposase |
| H7R03_RS23960 () | 12436..13458 | + | 1023 | WP_001310017.1 | IS21 family transposase IS100kyp | Transposase |
| H7R03_RS23965 () | 13458..14237 | + | 780 | WP_001323403.1 | IS21 family transposase IS100kyp | Transposase |
| H7R03_RS23970 () | 14305..14913 | + | 609 | Protein_14 | IS66 family transposase ISEc22 | Transposase |
| H7R03_RS23975 () | 14976..15767 | - | 792 | WP_000977394.1 | DUF4198 domain-containing protein | - |
| H7R03_RS23980 () | 15774..17744 | - | 1971 | WP_001298664.1 | Hemin receptor | VF |
| H7R03_RS23985 () | 18026..18462 | + | 437 | Protein_17 | IS3 family transposase IS2 | Transposase |
| H7R03_RS23990 () | 18987..19259 | + | 273 | WP_001322642.1 | Major pilu subunit operon regulatory protein PapB | VF |
| H7R03_RS23995 () | 19705..19880 | + | 176 | Protein_19 | IS3 family transposase | - |
| H7R03_RS24000 () | 20106..21275 | - | 1170 | WP_001072358.1 | hypothetical protein | - |
| H7R03_RS24005 () | 21642..21830 | + | 189 | WP_001309252.1 | hypothetical protein | - |
| H7R03_RS24010 () | 21951..22691 | + | 741 | WP_001066941.1 | tyrosine-type recombinase/integrase | - |
| H7R03_RS24015 () | 22976..23953 | - | 978 | WP_000361610.1 | RepB family plasmid replication initiator protein | - |
| H7R03_RS24020 () | 24739..25470 | + | 732 | WP_001617898.1 | hypothetical protein | - |
| H7R03_RS24025 () | 25839..26087 | - | 249 | Protein_25 | abortive infection family protein | - |
| H7R03_RS24030 () | 26145..26842 | + | 698 | Protein_26 | IS1 family transposase IS1R | Transposase |
| H7R03_RS24035 () | 26858..27187 | + | 330 | Protein_27 | TOBE domain-containing protein | - |
| H7R03_RS24040 () | 27296..28228 | - | 933 | WP_000081352.1 | homocysteine S-methyltransferase | - |
| H7R03_RS24045 () | 28215..29618 | - | 1404 | WP_001373486.1 | S-methylmethionine permease | - |
| H7R03_RS24050 () | 29826..30842 | + | 1017 | WP_012372828.1 | IS5 family transposase IS5D | Transposase |
| H7R03_RS24055 () | 31070..31387 | + | 318 | WP_001513659.1 | hypothetical protein | - |
| H7R03_RS24060 () | 31337..31750 | - | 414 | Protein_32 | IS3 family transposase ISLad1 | Transposase |
| H7R03_RS24065 () | 31674..32033 | - | 360 | WP_001513660.1 | hypothetical protein | - |
| H7R03_RS24070 () | 32061..32240 | - | 180 | WP_001513661.1 | hypothetical protein | - |
| H7R03_RS24075 () | 32245..32625 | - | 381 | WP_001216034.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin Detail |
| H7R03_RS24080 () | 32625..32846 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin Detail |
| H7R03_RS24085 () | 33029..34585 | + | 1557 | WP_001617892.1 | type I restriction-modification system subunit M | - |
| H7R03_RS24090 () | 34582..35865 | + | 1284 | WP_001617890.1 | restriction endonuclease subunit S | - |
| H7R03_RS24095 () | 35987..39103 | + | 3117 | WP_001553854.1 | HsdR family type I site-specific deoxyribonuclease | - |
| H7R03_RS24100 () | 39317..40014 | + | 698 | Protein_40 | IS1 family transposase IS1G | Transposase |
| H7R03_RS24105 () | 40151..41083 | - | 933 | WP_000991832.1 | hypothetical protein | - |
| H7R03_RS24110 () | 41087..42082 | - | 996 | WP_000246636.1 | hypothetical protein | - |
| H7R03_RS24115 () | 42790..43008 | + | 219 | WP_000813634.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin Detail |
| H7R03_RS24120 () | 43010..43315 | + | 306 | WP_001159868.1 | type II toxin-antitoxin system toxin CcdB | Toxin Detail |
| H7R03_RS24125 () | 43316..44122 | + | 807 | WP_000016982.1 | site-specific integrase | - |
| H7R03_RS24130 () | 44896..45651 | + | 756 | WP_000852146.1 | replication initiation protein RepE | - |
| H7R03_RS24135 () | 46239..47405 | + | 1167 | WP_000772446.1 | Sporulation initiation inhibitor protein Soj | VF |
| H7R03_RS24140 () | 47405..48376 | + | 972 | WP_000817036.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| H7R03_RS24145 () | 49243..50145 | + | 903 | WP_001348615.1 | DUF1281 domain-containing protein | - |
| H7R03_RS24150 () | 50149..50453 | + | 305 | Protein_50 | hypothetical protein | - |
| H7R03_RS24155 () | 50530..51213 | + | 684 | WP_000086185.1 | DNA methylase | - |
| H7R03_RS24160 () | 51214..51435 | + | 222 | WP_001104873.1 | hypothetical protein | - |
| H7R03_RS24165 () | 51449..51883 | + | 435 | WP_000274437.1 | DUF1380 family protein | - |
| H7R03_RS24170 () | 51934..52710 | + | 777 | WP_001753849.1 | hypothetical protein | - |
| H7R03_RS24175 () | 53250..53552 | + | 303 | WP_001671341.1 | antirestriction protein | - |
| H7R03_RS24180 () | 53599..54021 | + | 423 | WP_000271753.1 | DUF1380 family protein | - |
| H7R03_RS24185 () | 54018..54209 | + | 192 | WP_001027516.1 | hypothetical protein | - |
| H7R03_RS24190 () | 55244..55474 | + | 231 | WP_000218642.1 | hypothetical protein | - |
| H7R03_RS24195 () | 55526..56887 | + | 1362 | WP_000170714.1 | DUF3560 domain-containing protein | - |
| H7R03_RS24200 () | 56935..57498 | + | 564 | WP_001348621.1 | class I SAM-dependent methyltransferase | - |
| H7R03_RS24205 () | 57524..57772 | + | 249 | WP_001553845.1 | hypothetical protein | - |
| H7R03_RS24210 () | 57935..58270 | + | 336 | WP_013023883.1 | hypothetical protein | - |
| H7R03_RS24215 () | 58415..58954 | + | 540 | WP_000290841.1 | single-stranded DNA-binding protein | - |
| H7R03_RS24220 () | 59017..59250 | + | 234 | WP_000005990.1 | DUF905 family protein | - |
| H7R03_RS24225 () | 59316..61274 | + | 1959 | WP_000117179.1 | ParB/RepB/Spo0J family partition protein | - |
| H7R03_RS24230 () | 61329..61763 | + | 435 | WP_000845940.1 | conjugation system SOS inhibitor PsiB | - |
| H7R03_RS24235 () | 61760..62479 | + | 720 | WP_001276232.1 | plasmid SOS inhibition protein A | - |
| - () | 62491..62677 | + | 187 | NuclAT_0 | - | - |
| - () | 62491..62677 | + | 187 | NuclAT_0 | - | - |
| - () | 62491..62677 | + | 187 | NuclAT_0 | - | - |
| - () | 62491..62677 | + | 187 | NuclAT_0 | - | - |
| H7R03_RS24240 () | 62725..64094 | + | 1370 | WP_085947770.1 | IS3 family transposase IS150 | Transposase |
| - () | 64121..64161 | + | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 64121..64161 | + | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 64121..64161 | + | 41 | NuclAT_1 | - | Antitoxin Detail |
| - () | 64121..64161 | + | 41 | NuclAT_1 | - | Antitoxin Detail |
| H7R03_RS24245 () | 64205..64363 | + | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| H7R03_RS24250 () | 64806..65141 | + | 336 | WP_013023876.1 | hypothetical protein | - |
| H7R03_RS24255 () | 65054..65260 | + | 207 | WP_000275859.1 | hypothetical protein | - |
| H7R03_RS24260 () | 65285..65572 | + | 288 | WP_000107535.1 | hypothetical protein | - |
| H7R03_RS24265 () | 65691..66512 | + | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
| H7R03_RS24270 () | 66809..67411 | - | 603 | WP_000243712.1 | hypothetical protein | VF |
| H7R03_RS24275 () | 67742..68125 | + | 384 | WP_001151566.1 | relaxosome protein TraM | - |
| H7R03_RS24280 () | 68259..68936 | + | 678 | WP_001348626.1 | PAS domain-containing protein | - |
| H7R03_RS24285 () | 69024..69251 | + | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
| H7R03_RS24290 () | 69285..69647 | + | 363 | WP_000338606.1 | type IV conjugative transfer system pilin TraA | - |
| H7R03_RS24295 () | 69652..69963 | + | 312 | WP_000012107.1 | type IV conjugative transfer system protein TraL | - |
| H7R03_RS24300 () | 70037..70734 | + | 698 | Protein_80 | IS1 family transposase IS1G | Transposase |
| H7R03_RS24305 () | 70782..71102 | + | 321 | WP_001348757.1 | conjugal transfer protein TrbA | - |
| H7R03_RS24310 () | 71229..71513 | + | 285 | WP_001617873.1 | type-F conjugative transfer system pilin chaperone TraQ | - |
| H7R03_RS24315 () | 71500..72045 | + | 546 | WP_000059829.1 | type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB | - |
| H7R03_RS24320 () | 71975..72322 | + | 348 | WP_071571857.1 | P-type conjugative transfer protein TrbJ | - |
| H7R03_RS24325 () | 72270..72695 | + | 426 | WP_001348758.1 | F-type conjugal transfer protein TrbF | - |
| H7R03_RS24330 () | 72682..74055 | + | 1374 | WP_000944328.1 | conjugal transfer protein TraH | - |
| H7R03_RS24335 () | 74052..76871 | + | 2820 | WP_001007062.1 | conjugal transfer mating pair stabilization protein TraG | - |
| H7R03_RS24340 () | 76890..77387 | + | 498 | WP_000605862.1 | entry exclusion protein | - |
| H7R03_RS24345 () | 77419..78150 | + | 732 | WP_000850429.1 | complement resistance protein TraT | - |
| H7R03_RS24350 () | 78353..79132 | + | 780 | WP_000199914.1 | hypothetical protein | - |
| H7R03_RS24355 () | 79129..81309 | + | 2181 | WP_016238500.1 | type IV conjugative transfer system coupling protein TraD | - |
| H7R03_RS24360 () | 81309..86579 | + | 5271 | WP_001617867.1 | Multifunctional conjugation protein TraI | Relaxase |
| H7R03_RS24365 () | 86599..87345 | + | 747 | WP_000205718.1 | conjugal transfer pilus acetylase TraX | - |
| H7R03_RS24370 () | 87400..87960 | + | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
| H7R03_RS24375 () | 88091..88303 | + | 213 | WP_013023861.1 | hypothetical protein | - |
| H7R03_RS24380 () | 88862..89287 | + | 426 | WP_000422741.1 | IS66 family transposase ISEc23 | Transposase |
| H7R03_RS24385 () | 89284..89634 | + | 351 | WP_000624722.1 | IS66 family transposase ISEc23 | Transposase |
| H7R03_RS24390 () | 89665..91278 | + | 1614 | WP_000080195.1 | IS66 family transposase ISEc23 | Transposase |
| H7R03_RS24395 () | 91356..91642 | + | 287 | Protein_99 | DUF2726 domain-containing protein | - |
| - () | 91609..91669 | - | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 91609..91669 | - | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 91609..91669 | - | 61 | NuclAT_2 | - | Antitoxin Detail |
| - () | 91609..91669 | - | 61 | NuclAT_2 | - | Antitoxin Detail |
| H7R03_RS24400 () | 91714..91848 | + | 135 | WP_023144756.1 | type I toxin-antitoxin system Hok family toxin | Toxin Detail |
| H7R03_RS24405 () | 92145..92399 | + | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| H7R03_RS25280 () | 92505..92639 | + | 135 | Protein_102 | protein CopA/IncA | - |
| H7R03_RS24410 () | 92636..92710 | + | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
| H7R03_RS24415 () | 92703..93560 | + | 858 | WP_001617855.1 | incFII family plasmid replication initiator RepA | - |
| H7R03_RS24420 () | 94500..95153 | + | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| H7R03_RS24425 () | 95246..95503 | + | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| H7R03_RS24430 () | 95436..95837 | + | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| H7R03_RS24435 () | 96086..96501 | + | 416 | Protein_108 | IS1 family transposase | - |
| H7R03_RS24440 () | 96537..97082 | - | 546 | Protein_109 | Tn3 family transposase TnpA_Tn3 | Transposase |
| H7R03_RS24445 () | 97148..97852 | - | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| H7R03_RS24450 () | 98166..99041 | + | 876 | WP_032277257.1 | Beta-lactamase CTX-M-97 | ARG |
| H7R03_RS24455 () | 99076..99438 | + | 363 | Protein_112 | IS5 family transposase IS903B | Transposase |
| H7R03_RS24460 () | 99498..100202 | + | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| H7R03_RS24465 () | 100255..100587 | + | 333 | Protein_114 | EamA family transporter | - |
| H7R03_RS24470 () | 100619..101818 | - | 1200 | WP_000804064.1 | Tetracycline resistance protein, class C | ARG |
| H7R03_RS24475 () | 101924..102550 | + | 627 | WP_031606906.1 | tetracycline resistance transcriptional repressor TetR(A) | - |
| H7R03_RS24480 () | 102582..102818 | - | 237 | WP_042005022.1 | hypothetical protein | - |
| H7R03_RS24485 () | 102872..103708 | - | 837 | WP_000480972.1 | hypothetical protein | ARG |
| H7R03_RS24490 () | 103708..104511 | - | 804 | WP_001082319.1 | Aminoglycoside 3'-phosphotransferase | ARG |
| H7R03_RS24495 () | 104572..105387 | - | 816 | WP_001043260.1 | Dihydropteroate synthase | ARG |
| H7R03_RS24500 () | 105695..105871 | - | 177 | Protein_121 | replication protein C | - |
| H7R03_RS24505 () | 105932..106636 | + | 705 | WP_001067855.1 | IS6 family transposase IS26 | Transposase |
| H7R03_RS24510 () | 106758..107663 | + | 906 | WP_000219391.1 | hypothetical protein | ARG |
| H7R03_RS24515 () | 107660..108898 | + | 1239 | WP_000004159.1 | MFS transporter | - |
| H7R03_RS24520 () | 108898..109482 | + | 585 | WP_001137892.1 | TetR family transcriptional regulator | - |
| H7R03_RS24525 () | 109975..110739 | - | 765 | WP_001389365.1 | IS6 family transposase IS6100 | Transposase |
| H7R03_RS24530 () | 110857..110922 | - | 66 | Protein_127 | EAL domain-containing protein | - |
| H7R03_RS24535 () | 110966..111271 | - | 306 | WP_000130000.1 | hypothetical protein | Relaxase |
| H7R03_RS24540 () | 111282..112487 | - | 1206 | WP_000184001.1 | chromate efflux transporter | - |
| H7R03_RS24545 () | 112643..112846 | - | 204 | WP_000376616.1 | hypothetical protein | - |
| H7R03_RS24550 () | 112974..113813 | - | 840 | WP_000259031.1 | Dihydropteroate synthase | ARG |
| H7R03_RS24555 () | 113807..114154 | - | 348 | WP_000679427.1 | Multidrug transporter EmrE | ARG |
| H7R03_RS24560 () | 114360..115148 | - | 789 | WP_000503573.1 | Streptomycin 3''-adenylyltransferase | ARG |
| H7R03_RS24565 () | 115279..115752 | - | 474 | WP_001389366.1 | Dihydrofolate reductase type 1 | ARG |
| H7R03_RS24570 () | 115910..116659 | + | 750 | Protein_135 | IS91 family transposase ISAzo26 | Transposase |
| H7R03_RS24575 () | 116718..117422 | + | 705 | WP_001067858.1 | IS6 family transposase IS15DI | Transposase |
| H7R03_RS24580 () | 117472..117690 | - | 219 | Protein_137 | IS4 family transposase | - |
| H7R03_RS24585 () | 117705..118402 | - | 698 | Protein_138 | IS1 family transposase IS1X2 | Transposase |
| H7R03_RS24590 () | 118865..119023 | + | 159 | WP_000449408.1 | DsbA family protein | - |
| H7R03_RS24595 () | 119013..119519 | + | 507 | WP_000949452.1 | protein disulfide oxidoreductase | - |
| H7R03_RS24600 () | 119702..120517 | + | 816 | WP_012372823.1 | Na(+)-translocating NADH-quinone reductase subunit C | - |
| H7R03_RS24605 () | 120864..122750 | + | 1887 | WP_000118029.1 | FTR1 family iron permease | - |
| H7R03_RS24610 () | 122791..123318 | + | 528 | WP_000178050.1 | iron transporter | - |
| H7R03_RS24615 () | 123422..124801 | + | 1380 | WP_000119836.1 | DUF2318 domain-containing protein | - |
| H7R03_RS24620 () | 124804..126087 | + | 1284 | WP_000964653.1 | ABC transporter permease | - |
| H7R03_RS24625 () | 126077..127207 | + | 1131 | WP_000729218.1 | ABC transporter permease | - |
| H7R03_RS24630 () | 127212..127907 | + | 696 | WP_000117262.1 | Lipoprotein-releasing system ATP-binding protein LolD | VF |
| H7R03_RS24635 () | 127894..128379 | + | 486 | WP_001267176.1 | TlpA family protein disulfide reductase | - |
| H7R03_RS24640 () | 128404..128889 | + | 486 | WP_000874189.1 | hypothetical protein | - |
| H7R03_RS24645 () | 129011..129644 | + | 634 | Protein_150 | histidine-type phosphatase | - |
| H7R03_RS24650 () | 129794..129967 | - | 174 | Protein_151 | IS5 family transposase ISKpn26 | Transposase |
| H7R03_RS24655 () | 129968..130282 | - | 315 | Protein_152 | IS5 family transposase ISKpn26 | Transposase |
| H7R03_RS24660 () | 130955..131694 | - | 740 | Protein_153 | IS3 family transposase IS629 | Transposase |
| H7R03_RS24665 () | 131796..132056 | + | 261 | WP_000371882.1 | hypothetical protein | - |
| H7R03_RS24670 () | 132053..132562 | + | 510 | WP_000194542.1 | hypothetical protein | - |
| H7R03_RS24675 () | 132582..132929 | - | 348 | WP_000142452.1 | hypothetical protein | - |
| H7R03_RS24680 () | 133058..133393 | + | 336 | WP_001080732.1 | colicin transporter | - |
Similar MGE(s)
Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE.
| Detail | Organism | MGE type | Related TA | Genome accession | Coordinates | Mash distance |
|---|