| Effector Protein ID: 54298820 |
 T4SS name [ID] | Dot/Icm [40] |
| Gene symbol | - |
| Locus tag | lpp2887 |
| Strain | Legionella pneumophila str. Paris |
| Replicon | chromosome [GenBank: NC_006368] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 3296181..3296903 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LubX/legU2 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LubX has been proved to contribute to sustained NF-kappaB activation in A549 epithelial cells, and are essential for L. pneumophila replication (Bartfeld, et al, 2009) |
| UniProt ID | Q5X159 |
| KEGG ID | lpp:lpp2887 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | U-box [PF04564], Evalue: 4.7e-26, Aligned region: 32..101 U-box [PF04564], Evalue: 4.7e-26, Aligned region: 126..190 zf-RING_LisH [PF13445], Evalue: 2.2e-10, Aligned region: 126..161 |
| Protein Sequence: 240 a.a. [Download] |
| >gi|54298820|ref|YP_125189.1| hypothetical protein lpp2887 [Legionella pneumophila str. Paris] MATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKWLETKKE DPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPISKTLIK TPVITAQGKVYDQEALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREVQKNQIQPSVSN GFGFFSLNFLTSWLWGTEEKKEKTSSDMTY |
| - |
| Nucleotide Sequence: 723 bp [Download] |
| >gi|54295983|ref|NC_006368.1|:c3296903-3296181 Legionella pneumophila str. Paris, complete genome ATGGCGACGCGAAATCCTTTTGATATTGATCATAAAAGTAAATACTTAAGAGAAGCAGCATTAGAAGCCA ATTTATCTCATCCAGAAACAACACCAACAATGCTGACTTGCCCTATTGACAGCGGATTTCTAAAAGATCC CGTGATCACACCTGAAGGTTTTGTTTATAATAAATCCTCTATTTTAAAATGGTTAGAAACGAAAAAAGAA GACCCACAAAGCCGTAAACCCTTAACGGCTAAAGATTTGCAACCATTCCCCGAGTTATTGATTATAGTCA ATAGATTTGTTGAGACACAAACGAACTATGAAAAATTAAAAAACAGATTAGTGCAAAATGCTCGGGTTGC TGCACGCCAAAAAGAATACACTGAAATTCCGGATATATTTCTTTGCCCAATAAGTAAAACGCTTATCAAA ACACCTGTCATTACTGCCCAAGGGAAAGTATATGATCAAGAAGCATTAAGTAACTTTCTTATCGCAACGG GTAATAAAGATGAAACAGGCAAAAAATTATCCATTGATGATGTAGTGGTGTTTGATGAACTCTATCAACA GATAAAAGTTTATAATTTTTACCGCAAACGCGAAGTGCAAAAAAATCAAATTCAACCTTCAGTAAGTAAT GGTTTTGGCTTTTTTAGCTTGAATTTTCTCACCTCATGGTTATGGGGAACTGAGGAGAAAAAAGAAAAGA CATCATCTGATATGACGTACTAA |
| Reference |
(1) Quaile AT et al. (2015). Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila. Structure. 23(8):1459-1469. [PudMed:26146184] 
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| (2) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |