| Effector Protein ID: 54298515 |
 T4SS name [ID] | Dot/Icm [40] |
| Gene symbol | sidC |
| Locus tag | lpp2579 |
| Strain | Legionella pneumophila str. Paris |
| Replicon | chromosome [GenBank: NC_006368] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2936942..2939656 [+] |
| Product | SidC protein (substrate of the Dot/Icm system) |
| Effector type | Protein |
| Descripton | SidC |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. (Ragaz et al, 2008) |
| UniProt ID | Q5X214 |
| KEGG ID | lpp:lpp2579 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 904 a.a. [Download] |
| >gi|54298515|ref|YP_124884.1| SidC protein (substrate of the Dot/Icm system) [Legionella pneumophila str. Paris] MVDVIKFKEPERCDYLYIDENNKVHILLPIVGGDEIGLDNTCQTAVELITFFYGSAHSGVTKYSAEHQLS EYKRQLEEDIKAINSQKKISPHAYDDLLKEKTERLQQIEKYIELIQVLKKQYDEQNDIRQLRTGGIPQLP SGVKEIIKSSENAFAVRLSPYDNDKFTRFDDPLFNVKRNISKYDTPSRQAPIPIYEGLGYRLRSTLFPED KTPTPINKKSSKEKIVETVLAQVDADYMKDGDKEQKLEELKKLIQQELVKIDSNLSVNMSRDGKEVNLSY LDIVMALDDDSTIKDWIEGIIEVSIDPTVWEAQASSPFYDGAKEIKSDHEADRISIRVQYLLAEANIYCK TNKLSDANFGEFFDKEPHATEIAKRVKEGFAQGAEIEPIIYDYINSNHAELGLKSPLTGKQQQEITEKFT RHYNTIKESPHFDEFFVADPDKKGNIFSHQGRISCHFLDFFTRQTKGKHPLGDLASHQEALQEGTSNRLH HKNEVVAQGYEKLDQFKKEVVKLLAENKPKELLDYLVATSPTGVPNYSMLSKETQNYIAYNRNWPAIQKE LEKATSIPESQKQDLLRLLSRDNLQHDNLSAITWSKYSSKPLLDVELNKIAEGLELTAKIYNEKRGREWW FKGSRNEARKTQCEELQRVSKEINTLMQSESLTKSQVLEKVLNSIETLDKIDRDISAESNWFQSTLQKEV RLFRDQLKDICQLDKYAFKSTKLDEIISLEMEEQFQKIQDPAVQQIVRDLPSHCHNDEAIEFFKTLNPEE AAKVASYLSLEYREINKSTDKKTLLEQDIPRLFKEVNTQLLSKLKEEKAIDEQVHEKLSQLADKIPPEHF TRNNIIKWSTNPEKLEESNLNEPIKSVQSPTTKQTSKQFREAMGEITGRNEPPTDTLYTGVIKK |
| - |
| Nucleotide Sequence: 2715 bp [Download] |
| >gi|54295983|ref|NC_006368.1|:2936942-2939656 Legionella pneumophila str. Paris, complete genome ATGGTTGACGTAATCAAATTCAAAGAGCCGGAACGTTGTGACTACCTATATATTGATGAAAACAACAAAG TTCATATCCTTTTACCGATTGTAGGAGGAGATGAAATAGGTTTAGACAACACCTGTCAAACAGCAGTTGA ATTGATCACGTTTTTCTATGGCAGTGCACACAGTGGTGTGACCAAATATTCTGCCGAACACCAACTTAGT GAATACAAAAGGCAATTGGAAGAAGACATCAAAGCCATTAATAGCCAAAAGAAAATTTCACCTCATGCTT ATGACGATTTATTAAAAGAGAAAACGGAACGCCTGCAACAGATTGAAAAGTACATTGAATTAATTCAAGT ACTAAAAAAACAATATGATGAGCAAAATGACATCAGGCAACTCCGTACTGGAGGGATTCCACAATTACCC TCTGGTGTAAAGGAAATCATTAAATCCTCTGAAAATGCTTTCGCTGTGAGACTTTCTCCTTATGACAACG ATAAATTTACTCGCTTTGATGACCCTTTATTCAATGTCAAAAGAAACATCTCTAAATACGATACGCCCTC AAGGCAAGCTCCTATTCCAATATACGAGGGATTAGGGTATCGCCTGCGTTCAACTCTCTTCCCGGAAGAT AAAACACCGACTCCAATCAATAAAAAATCATCTAAGGAAAAAATAGTAGAAACCGTACTGGCACAAGTAG ATGCGGACTATATGAAAGATGGAGACAAGGAACAAAAACTGGAAGAGTTAAAAAAACTGATTCAACAAGA GCTGGTAAAAATTGACTCCAATCTGTCAGTAAACATGAGTCGCGATGGTAAAGAAGTCAACCTGAGCTAT TTGGATATCGTCATGGCTTTAGACGATGATTCCACTATTAAAGATTGGATTGAAGGGATTATTGAAGTAT CAATAGATCCTACTGTATGGGAAGCTCAAGCATCCAGCCCTTTCTATGATGGTGCTAAAGAAATAAAATC AGACCACGAAGCAGACAGGATATCCATCAGAGTTCAGTACCTGTTGGCGGAAGCAAACATTTATTGTAAA ACAAACAAATTATCGGATGCTAACTTCGGAGAATTTTTCGACAAAGAGCCTCATGCTACAGAAATTGCAA AAAGAGTAAAAGAAGGATTTGCGCAAGGTGCGGAGATAGAACCAATTATATACGACTATATTAACAGCAA TCATGCCGAGTTAGGATTAAAATCCCCGTTAACAGGCAAGCAACAACAAGAAATTACTGAGAAATTTACA AGACATTATAATACGATTAAAGAATCTCCTCATTTCGATGAGTTTTTTGTCGCTGATCCCGATAAAAAAG GCAATATCTTTTCTCATCAAGGCAGAATCAGTTGTCATTTTCTGGATTTCTTTACCCGACAAACCAAAGG CAAACATCCTCTTGGTGATCTTGCAAGTCATCAGGAAGCTCTCCAGGAAGGAACCTCCAATCGGTTACAT CACAAGAATGAGGTAGTGGCCCAGGGGTACGAAAAACTGGATCAATTCAAGAAAGAGGTTGTCAAACTGC TGGCTGAGAATAAACCAAAAGAATTATTGGATTATTTAGTTGCTACCTCACCTACAGGTGTTCCAAATTA CTCCATGCTTTCGAAGGAAACTCAAAATTACATTGCTTACAATCGTAACTGGCCAGCCATTCAAAAAGAG CTGGAAAAGGCTACCAGCATACCAGAGAGTCAAAAACAAGATCTTTTAAGATTGCTTTCTCGTGATAATT TACAACACGATAATCTAAGCGCAATTACCTGGTCAAAATATTCCTCCAAGCCATTATTGGATGTGGAATT AAATAAAATCGCTGAAGGATTAGAACTCACTGCAAAAATTTACAACGAAAAGAGAGGACGCGAATGGTGG TTTAAAGGTTCAAGAAATGAAGCCCGTAAGACCCAATGTGAAGAATTACAAAGAGTATCCAAAGAAATCA ATACTCTTATGCAAAGTGAATCTTTAACGAAAAGCCAGGTCCTTGAAAAGGTTTTAAACTCTATTGAAAC ATTAGATAAAATTGACAGAGACATTTCTGCCGAATCCAATTGGTTTCAAAGTACTCTGCAAAAGGAAGTC AGGTTATTTCGAGATCAATTGAAAGATATTTGCCAATTGGACAAGTATGCCTTTAAATCAACAAAACTTG ATGAAATCATCTCTCTGGAAATGGAAGAACAATTTCAAAAGATACAAGATCCTGCTGTTCAACAAATTGT CAGGGACTTGCCTTCTCATTGCCACAATGATGAAGCAATTGAATTCTTTAAGACATTGAACCCTGAAGAG GCAGCAAAAGTAGCTAGCTATTTAAGCCTGGAATACAGGGAAATTAATAAATCAACCGATAAGAAAACTC TCCTTGAGCAAGATATTCCCAGACTGTTTAAAGAAGTCAATACGCAGTTACTCTCCAAACTAAAAGAAGA AAAAGCTATTGATGAGCAAGTTCATGAAAAACTCAGTCAACTGGCTGACAAAATTCCTCCTGAGCATTTT ACAAGAAATAACATTATAAAATGGTCTACTAACCCTGAAAAGCTTGAGGAATCAAATCTTAATGAGCCAA TCAAATCAGTCCAAAGCCCTACTACTAAACAAACATCAAAACAATTCAGGGAAGCGATGGGTGAAATCAC TGGAAGAAATGAGCCTCCTACAGACACTTTGTACACGGGAGTTATAAAGAAATAG |
| Reference |
(1) Harding CR; Schroeder GN; Reynolds S; Kosta A; Collins JW; Mousnier A; Frankel G (2012). Legionella pneumophila pathogenesis in the Galleria mellonella infection model. Infect Immun. . [PudMed:22645286] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |