| Effector Protein ID: 54298071 |
 T4SS name [ID] | Dot/Icm [40] |
| Gene symbol | - |
| Locus tag | lpp2128 |
| Strain | Legionella pneumophila str. Paris |
| Replicon | chromosome [GenBank: NC_006368] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2421091..2422908 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | LegS2/LpSpl |
| T4CP requirement | T4CP Depedent |
| Target/Effection | LegS2 is homologous to eukaryotic sphingosine-1-phosphate lyase and localizes to the mitochondria in host cells (Degtyar, et al. 2009) LpSpl possesses lyase activity and that it disrupts sphingolipid metabolism in the host cells. LpSpl plays a critical and previously unknown role in decreasing autophagy and is a unique virulence factor facilitating intracellular replication of L. pneumophila. |
| UniProt ID | Q5X3A8 |
| KEGG ID | lpp:lpp2128 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Pyridoxal_deC [PF00282], Evalue: 1.2e-15, Aligned region: 188..376 Aminotran_5 [PF00266], Evalue: 9.9e-10, Aligned region: 184..486 DegT_DnrJ_EryC1 [PF01041], Evalue: 2.1e-05, Aligned region: 210..328 |
| Protein Sequence: 605 a.a. [Download] |
| >gi|54298071|ref|YP_124440.1| hypothetical protein lpp2128 [Legionella pneumophila str. Paris] MFGFISDLLTAAVSSLDELLQDTPAHQIILGTAALYFLYNQYHNPSISRWCRSRNNASMKQRIIDSAYAL AKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSAFDVDVEKCHFDFLSVTND SPEREFLVGRGDGKDSGALYAIHPKELTELLKEVYGATALTNPLHDKWPRINAMQAEVIRWCQNLFHGSK EGYGLLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKKTGAVNP NVMSSYITRNTAVMVGSAPSFMNGIHDPISELGQLAKKKNVPFHVDACLGGFLTAFLDTSSEPMDFRVPG VTSISADLHKYGCCPKGTSVCLFSEDSPALSVYAALNWSGGLYATPGILDGSTSGARVAEVYATLSYYGK NKYQEIAKSIIRLRNAIQKELTALVEEGNGLTSEDIYVYGNPQWSILGFRSNTCNAHFIADELEKRGWKL NLLQNPDGFHLCLTHVHTLVGSFETQFIKDLREAVIDVKNYPPGKKPSGNVKVYGAVGMMPVELQKEICK QYQKARLDFTAASHGSLGIFAPSSTEEDDGLRNRKVGEQKVQTSL |
| - |
| Nucleotide Sequence: 1818 bp [Download] |
| >gi|54295983|ref|NC_006368.1|:c2422908-2421091 Legionella pneumophila str. Paris, complete genome ATGTTCGGTTTTATTTCAGATTTATTAACAGCAGCAGTCAGTTCTTTAGATGAATTATTACAAGATACTC CGGCACATCAAATCATATTAGGCACAGCGGCTCTTTATTTTCTTTATAATCAATACCATAACCCATCGAT TTCCAGGTGGTGCCGTAGCCGCAATAACGCCAGTATGAAGCAGCGTATTATTGATAGTGCTTACGCCTTG GCAAAAAATTTACCTGGTGTGAATCAGATCATTGAGAAAGAGCTCAATAAAGAACTCTCTTCAACGAGAG AAAAATTGAGAATTCAGCGTTCCGGTATGACTCTCAGGGAGGAAATACCTGAGGAAGGGCTTTCTCCCCA AGATATTTTGAGTGCATTTGATGTGGATGTGGAAAAATGTCATTTTGATTTTTTATCCGTAACTAATGAC AGCCCTGAGAGGGAGTTTCTTGTTGGAAGAGGGGATGGTAAAGATTCAGGTGCATTATACGCTATTCACC CTAAGGAATTGACAGAGCTGCTTAAAGAAGTTTATGGGGCAACCGCTCTAACTAATCCTTTGCATGATAA ATGGCCTCGAATTAACGCAATGCAAGCGGAGGTGATTCGCTGGTGTCAAAATTTGTTTCATGGTTCAAAA GAAGGTTATGGTTTATTAACTCATGGGGGTACGACCAGCATTATTGAGGCGATGGCTGCTTATGTCATTC GCGCAAGGGCAAAAGGCATTGATTATCCTGAAATTGTCGTTCCTGAAACAGCACATGCTGCATTTAAAAA AGCAGCCGAGTTAACTGGAGCAATATTAATTACGGTTCCTGTTGATAAAAAAACGGGTGCGGTGAATCCC AATGTCATGAGTTCCTATATTACCAGAAACACTGCTGTAATGGTTGGATCTGCTCCATCGTTCATGAATG GAATTCATGATCCTATCTCTGAGCTAGGCCAATTAGCAAAGAAAAAAAATGTTCCTTTTCATGTAGATGC CTGTTTGGGTGGATTTTTAACGGCTTTTTTAGACACTTCATCCGAGCCTATGGATTTTAGAGTGCCTGGA GTGACTTCCATTTCAGCCGACTTGCATAAATATGGCTGTTGTCCAAAAGGCACCTCTGTTTGTCTTTTTA GTGAGGATTCGCCTGCTTTGTCGGTTTATGCCGCATTAAACTGGTCAGGTGGATTGTATGCTACGCCAGG AATTCTGGATGGTTCAACCAGTGGAGCTCGTGTCGCGGAAGTCTATGCTACATTGTCTTACTATGGGAAA AATAAATATCAGGAAATCGCCAAAAGCATTATCAGATTACGCAATGCTATTCAAAAAGAATTGACGGCAT TAGTGGAAGAAGGTAATGGATTAACCAGCGAGGATATTTATGTTTATGGTAATCCTCAATGGTCCATTCT GGGTTTTAGAAGTAACACTTGCAATGCCCATTTCATTGCCGATGAATTGGAGAAACGGGGGTGGAAGCTT AACTTGCTACAAAATCCGGATGGGTTTCATTTATGTTTGACCCATGTGCACACTTTAGTAGGAAGCTTCG AGACGCAATTTATCAAAGATTTGAGAGAGGCGGTGATTGATGTTAAAAATTATCCCCCTGGAAAGAAACC AAGCGGTAATGTCAAAGTGTATGGTGCTGTCGGTATGATGCCGGTTGAACTTCAGAAAGAAATTTGTAAA CAATATCAAAAAGCCCGCCTTGATTTTACAGCAGCCAGCCACGGGAGCTTGGGGATATTTGCACCTTCAT CTACAGAAGAGGACGATGGGCTTAGAAACAGGAAAGTAGGGGAACAAAAAGTGCAAACCTCGCTTTGA |
| Reference |
(1) Rolando M et al. (2016). Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy. Proc Natl Acad Sci U S A. 113(7):1901-6. [PudMed:26831115] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |