| Effector Protein ID: 54298025 |
 T4SS name [ID] | Dot/Icm [40] |
| Gene symbol | - |
| Locus tag | lpp2082 |
| Strain | Legionella pneumophila str. Paris |
| Replicon | chromosome [GenBank: NC_006368] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2360600..2361064 [+] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | AnkB/legAU13/ceg27 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkB is essential for Legionella-containing vacuole (LCV) acquisition of polyubiquitinated proteins in both macrophage and amoeba hosts |
| UniProt ID | Q5X3F4 |
| KEGG ID | lpp:lpp2082 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 1.9e-15, Aligned region: 62..122 Ank_2 [PF12796], Evalue: 1.9e-15, Aligned region: 63..133 Ank_4 [PF13637], Evalue: 4.6e-09, Aligned region: 61..113 F-box-like [PF12937], Evalue: 2.4e-06, Aligned region: 6..44 |
| Protein Sequence: 154 a.a. [Download] |
| >gi|54298025|ref|YP_124394.1| hypothetical protein lpp2082 [Legionella pneumophila str. Paris] MKKNFFSDLPEETIVNTLSFLKANTLGRIAQTCQFFNRLANDKHLELHQLRQQRIKRELWGNLMMAARSN NLEEVKKILKKGIDPAQTNSYHLNRTPLLAAIEGKAYQTANYLWRKYTFDPNFKDNYGDSPISLLKKQLA NPAFKDKEKNKYAP |
| - |
| Nucleotide Sequence: 465 bp [Download] |
| >gi|54295983|ref|NC_006368.1|:2360600-2361064 Legionella pneumophila str. Paris, complete genome ATGAAAAAGAATTTTTTTTCTGATCTTCCTGAGGAAACAATTGTCAATACATTGAGTTTCTTAAAAGCAA ACACACTAGGTCGTATAGCTCAGACATGTCAATTTTTTAATCGCTTGGCTAATGATAAACATCTGGAACT GCATCAACTAAGACAACAACGTATAAAGCGAGAGCTATGGGGAAATCTTATGATGGCGGCAAGAAGCAAT AACCTGGAAGAGGTCAAAAAGATTCTAAAAAAAGGAATCGATCCAGCCCAGACCAATAGCTACCACTTAA ATAGAACACCTTTACTTGCAGCTATCGAAGGAAAAGCATATCAAACTGCAAATTACCTCTGGAGAAAATA CACTTTCGATCCAAATTTTAAAGATAACTATGGTGATTCACCTATCTCTCTTCTTAAAAAGCAACTGGCA AATCCAGCCTTCAAGGATAAGGAAAAAAACAAATACGCGCCTTGA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Lomma M et al. (2010). The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication. Cell Microbiol. 12(9):1272-91. [PudMed:20345489] 
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| experimental literature |
| in silico analysis literature |