| Effector Protein ID: 54297632 |
 T4SS name [ID] | Dot/Icm [40] |
| Gene symbol | - |
| Locus tag | lpp1683 |
| Strain | Legionella pneumophila str. Paris |
| Replicon | chromosome [GenBank: NC_006368] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1892084..1893769 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | AnkI/legAS4/RomA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | RomA localizes to the infected cell nucleus where it promotes a burst of H3K14 methylation and consequently decreases H3K14 acetylation, an activating histone mark, to repress host gene expression. |
| UniProt ID | Q5X4J3 |
| KEGG ID | lpp:lpp1683 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | SET [PF00856], Evalue: 1.2e-18, Aligned region: 146..250 Ank_2 [PF12796], Evalue: 1.2e-14, Aligned region: 348..379 Ank_2 [PF12796], Evalue: 1.2e-14, Aligned region: 354..449 Ank [PF00023], Evalue: 1.3e-10, Aligned region: 351..379 Ank_3 [PF13606], Evalue: 1.3e-10, Aligned region: 351..377 Ank_4 [PF13637], Evalue: 5.2e-09, Aligned region: 352..381 Ank_5 [PF13857], Evalue: 4.2e-08, Aligned region: 350..380 |
| Protein Sequence: 561 a.a. [Download] |
| >gi|54297632|ref|YP_124001.1| hypothetical protein lpp1683 [Legionella pneumophila str. Paris] MQNRAKNTLIEYNGSLMIILYDFLQESSVMPRSKNDSNLKKKSALQSKFKEQQWNHGSKEHKSKFKFTQR KAKKKGPGMTHLPGNIYTLFTPVNGLKNNAQLTDTSKIMVNLHIDNMSSSDYIPSAIDRTDLVIVQPVHL LRKTGGRGLFAREDIPKGTCIGIYTGEVYSEQEFEQYLMEHVGSDKSYAMYVGGRVVDAARKGNLTRYIN FSDSQDNAEFVETTLNRKKVVKVITTKNIKAGQQLLINYNTYEEQASRYYYFLNPGDGWLSAQEFYQTYQ SQYRLEQMPYNLEGFDLKAGDRILMTQIGRIIFANYSLAKEQELNASDIDLPFLKVGSDEKILDFDEADT FTPLMAACYLGQVENVKWLIEHGANIDQQQSHSGHCPLSLTLKGYSLAKDTKKYIDIIQLLIKNQVNLLV HDRSDKTFLHNAALVLNNLDFQSVVKFLIGQNPIDINEYFTYIDENDFDIVMHCYNNKLFDKALVLLAFY PDYFKRNYMSDNEGHNQFNINAFRKAIKDFNSNERNLLLMQLRESSLHLPEDLLEQLGIMDSNITLESKF F |
| - |
| Nucleotide Sequence: 1686 bp [Download] |
| >gi|54295983|ref|NC_006368.1|:c1893769-1892084 Legionella pneumophila str. Paris, complete genome ATGCAAAATAGAGCAAAAAATACTCTAATAGAGTATAATGGCTCCTTAATGATTATTTTATATGATTTTT TACAAGAGAGTAGTGTTATGCCAAGAAGCAAGAATGATAGCAACCTTAAAAAGAAAAGTGCCCTTCAGTC AAAGTTTAAAGAACAGCAATGGAATCATGGTAGCAAAGAGCACAAGTCTAAATTTAAATTTACCCAAAGA AAGGCAAAGAAAAAAGGACCTGGGATGACACACCTCCCAGGTAATATTTACACACTGTTTACCCCCGTCA ATGGATTGAAAAACAATGCTCAATTGACTGACACGAGCAAAATTATGGTTAATTTGCATATTGATAACAT GTCAAGCAGTGATTACATTCCATCTGCTATAGACAGAACTGATCTTGTTATTGTTCAGCCTGTCCATTTA CTCAGAAAAACCGGTGGGCGAGGTTTATTTGCCAGAGAAGATATCCCAAAGGGGACTTGTATTGGTATTT ACACAGGAGAAGTGTATTCTGAACAAGAATTTGAACAATATCTAATGGAGCATGTTGGTTCTGATAAAAG TTACGCGATGTATGTTGGGGGACGGGTAGTTGATGCAGCAAGAAAAGGTAATTTGACTCGTTATATCAAT TTTTCGGATAGCCAGGATAATGCAGAGTTTGTTGAAACTACATTGAATCGCAAGAAAGTAGTAAAAGTTA TAACCACTAAAAACATCAAGGCAGGACAACAACTATTAATCAACTATAATACCTACGAAGAGCAAGCTTC CAGGTATTACTACTTTCTTAATCCTGGCGATGGTTGGCTATCGGCACAAGAATTTTATCAAACTTACCAA TCTCAGTACCGATTAGAACAAATGCCCTATAATTTGGAAGGATTTGATCTTAAAGCAGGAGATAGAATTT TAATGACTCAAATAGGACGGATAATTTTCGCTAACTATTCCCTTGCAAAAGAACAAGAATTAAATGCCTC AGATATCGATTTGCCATTTTTAAAAGTAGGTTCTGACGAAAAAATATTAGATTTTGATGAGGCGGATACA TTCACCCCTTTGATGGCTGCCTGTTATCTTGGACAAGTTGAAAATGTAAAATGGCTTATTGAACATGGCG CTAATATCGATCAACAACAAAGTCATTCTGGTCATTGTCCTTTGAGTTTGACATTGAAAGGGTATTCTTT AGCGAAGGATACCAAAAAATACATCGATATCATTCAACTATTGATTAAAAATCAGGTTAATCTTTTAGTG CATGACCGATCTGACAAGACTTTTTTACATAATGCCGCATTAGTACTGAATAACCTTGATTTTCAATCTG TTGTAAAATTTTTAATAGGACAAAATCCTATTGATATCAATGAATACTTTACATACATCGATGAGAATGA TTTCGATATCGTCATGCATTGTTATAACAATAAATTATTTGATAAAGCTCTTGTTTTATTAGCTTTTTAT CCGGATTATTTTAAAAGAAATTATATGAGTGATAATGAAGGCCATAATCAATTTAATATTAATGCTTTTA GAAAAGCGATAAAAGATTTTAATTCAAATGAGCGTAATCTTTTATTAATGCAGCTCAGGGAGAGCAGTTT GCATTTGCCTGAAGACTTGTTAGAGCAATTAGGTATTATGGATTCAAATATCACACTCGAAAGCAAGTTT TTTTGA |
| Reference |
(1) Monica Rolando et al. (2013). Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication. Cell Host Microbe. 13(4):395-405. [PudMed:23601102] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| experimental literature |
| in silico analysis literature |