T4SS ID500
StrainWolbachia endosymbiont strain TRS of Brugia malayi
Repliconchromosome [Browse all T4SS(s) in this replicon]
Location365277..371319; 772818..773606; 986653..989007; 1051828..1066132
Functioneffector translocation
ClassificationType IVA; Type P
sequence This T4SS has been mentioned in a genome sequencing report.

T4SS components

The information of T4SS components from NC_006833
Region 1: 365277..371319
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0276 (dnaA)361157..362539 [+], 138358584534chromosome replication initiator DnaA 
2Wbm0277362563..363813 [-], 125158584535calcineurin-like phosphoesterase 
3Wbm0278364122..365204 [+], 108358584536GTP cyclohydrolase II 
4Wbm0279365277..365960 [+], 68458584537Type IV secretory pathway, component VirB8  VirB8
5Wbm0280365947..366753 [+], 80758584538Type IV secretory pathway, component VirB9  VirB9
6Wbm0281366770..368266 [+], 149758584539Type IV secretory pathway, VirB10 component  VirB10
7Wbm0282368268..369275 [+], 100858584540type IV secretion system ATPase VirB11  VirB11
8Wbm0283369289..371319 [+], 203158584541type IV secretion system component VirD4  VirD4
9Wbm0284371438..372283 [+], 84658584542Outer surface protein Wsp 
10Wbm0285372470..373405 [-], 93658584543methylase of polypeptide chain release factor 
Region 2: 772818..773606
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0590768732..769190 [-], 45958584847hypothetical protein 
2Wbm0591772818..773606 [+], 78958584848Type IV secretory pathway, VirB9 component  VirB9
3Wbm0592773630..775135 [-], 150658584849monovalent cation/H+ antiporter subunit D 
4Wbm0593775225..776415 [-], 119158584850queuine/archaeosine tRNA-ribosyltransferase 
5Wbm0594776416..776916 [-], 50158584851NADH dehydrogenase subunit E 
Region 3: 986653..989007
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0748983225..983653 [-], 42958585005hypothetical protein 
2Wbm0749983877..986672 [-], 279658585006hypothetical protein 
3Wbm0750986653..989007 [-], 235558585007Type IV secretory pathway, VirB4 components  VirB4
4Wbm0751989038..989415 [-], 37858585008hypothetical protein 
5Wbm0752989526..990761 [-], 123658585009hypothetical protein 
6Wbm0753990873..991913 [-], 104158585010trans-2-enoyl-ACP reductase, FabK 
7Wbm0754991919..992392 [-], 47458585011cytochrome B561 
Region 4: 1051828..1066132
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1Wbm0790 (pyrE)1047828..1048433 [+], 60658585047orotate phosphoribosyltransferase 
2Wbm07911050523..1051071 [-], 54958585048N-6 adenine-specific DNA methylase 
3Wbm07921051188..1051835 [-], 64858585049hypothetical protein 
4Wbm07931051828..1055067 [-], 324058585050Type IV secretory pathway, VirB6 components  VirB6
5Wbm07941055217..1058339 [-], 312358585051Type IV secretory pathway, VirB6 components  VirB6
6Wbm07951058336..1060738 [-], 240358585052Type IV secretory pathway, VirB6 components 
7Wbm07961060804..1063428 [-], 262558585053Type IV secretory pathway, VirB6 components  VirB6
8Wbm07971063421..1065826 [-], 240658585054type IV secretion system ATPase VirB4  VirB4
9Wbm07981065836..1066132 [-], 29758585055type IV secretion system protein VirB3  VirB3
10Wbm0799 (lysK)1066331..1067770 [+], 144058585056lysyl-tRNA synthetase 
11Wbm08001068652..1069641 [-], 99058585057glutamine amidotransferase domain-containing protein 
12Wbm0801 (coaD)1069887..1070390 [+], 50458585058phosphopantetheine adenylyltransferase 
13Wbm08021070459..1070656 [+], 19858585059NADH:ubiquinone oxidoreductase Fe-S subunit 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

wBm0014, wBm0032, wBm0044, wBm0057, wBm0064, wBm0070, wBm0076, wBm0114, wBm0152, wBm0213, wBm0222, wBm0277, wBm0284, wBm0287, wBm0447

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1Wbm0014 20371..20991 [+], 62158584275cytochrome c biogenesis protein CcmAexperimental  wBm0014
2Wbm0032 (trmE)41626..42954 [+], 132958584293tRNA modification GTPase TrmEexperimental  wBm0032
3Wbm0044 55843..57120 [-], 127858584305amino acid transporterexperimental  wBm0044
4Wbm0057 77507..77824 [-], 31858584318hypothetical proteinexperimental  wBm0057
5Wbm0064 85660..86817 [+], 1158585843252-polyprenyl-6-methoxyphenol 4-hydroxylaseexperimental  wBm0064
6Wbm0070 92860..94146 [+], 128758584331Mg2+/Co2+ transporterexperimental  wBm0070
7Wbm0076 98390..99568 [+], 117958584337WAS family proteinexperimental  wBm0076
8Wbm0114 (def)148853..149392 [+], 54058584374peptide deformylaseexperimental  wBm0114
9Wbm0152 192758..193237 [-], 48058584412Outer membrane protein, pal-likeexperimental  wBm0152
10Wbm0213 283449..284264 [-], 81658584473hypothetical proteinexperimental  wBm0213
11Wbm0222 294345..294779 [+], 43558584482preprotein translocase subunit YajCexperimental  wBm0222
12Wbm0277 362563..363813 [-], 125158584535calcineurin-like phosphoesteraseexperimental  wBm0277
13Wbm0284 371438..372283 [+], 84658584542Outer surface protein Wspexperimental  wBm0284
14Wbm0287 376943..377188 [+], 24658584545ankyrin repeat-containing proteinexperimental  wBm0287
15Wbm0447 581536..584862 [+], 332758584704ankyrin repeat-containing proteinexperimental  wBm0447
experimental T4SE derived from experimental literature.

Download FASTA format files
Proteins        Genes
(1) Turner JD; Langley RS; Johnston KL; Gentil K; Ford L; Wu B; Graham M; Sharpley F; Slatko B; Pearlman E; Taylor MJ (2009). Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem. 284(33):22364-78. [PudMed:19458089] in_silico
(2) Foster J; Ganatra M; Kamal I; Ware J; Makarova K; Ivanova N; Bhattacharyya A; Kapatral V; Kumar S; Posfai J; Vincze T; Ingram J; Moran L; Lapidus A; Omelchenko M; Kyrpides N; Ghedin E; Wang S; Goltsman E; Joukov V; Ostrovskaya O; Tsukerman K; Mazur M; Comb D; Koonin E; Slatko B (2005). The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol. 3(4):e121. [PudMed:15780005]
in_silico This literature contains bioinformatics investigation