T4SS ID	500
Strain	Wolbachia endosymbiont strain TRS of Brugia malayi
Replicon	chromosome [Browse all T4SS(s) in this replicon]
Accession	NC_006833
Location	365277..371319; 772818..773606; 986653..989007; 1051828..1066132
Name	VirB
Function	effector translocation
Classification	Type IVA; Type P
This T4SS has been mentioned in a genome sequencing report.

T4SS components

Component	VirB1	VirB2	VirB3	VirB4	VirB5	VirB6	VirB7	VirB8	VirB9
Number	0	0	1	2	0	3	0	1	2
Component	VirB10	VirB11	VirD4
Number	1	1	1

The information of T4SS components from NC_006833
Region 1: 365277..371319
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	Wbm0276 (dnaA)	361157..362539 [+], 1383	58584534	chromosome replication initiator DnaA
2	Wbm0277	362563..363813 [-], 1251	58584535	calcineurin-like phosphoesterase
3	Wbm0278	364122..365204 [+], 1083	58584536	GTP cyclohydrolase II
4	Wbm0279	365277..365960 [+], 684	58584537	Type IV secretory pathway, component VirB8	VirB8
5	Wbm0280	365947..366753 [+], 807	58584538	Type IV secretory pathway, component VirB9	VirB9
6	Wbm0281	366770..368266 [+], 1497	58584539	Type IV secretory pathway, VirB10 component	VirB10
7	Wbm0282	368268..369275 [+], 1008	58584540	type IV secretion system ATPase VirB11	VirB11
8	Wbm0283	369289..371319 [+], 2031	58584541	type IV secretion system component VirD4	VirD4
9	Wbm0284	371438..372283 [+], 846	58584542	Outer surface protein Wsp
10	Wbm0285	372470..373405 [-], 936	58584543	methylase of polypeptide chain release factor
Region 2: 772818..773606
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	Wbm0590	768732..769190 [-], 459	58584847	hypothetical protein
2	Wbm0591	772818..773606 [+], 789	58584848	Type IV secretory pathway, VirB9 component	VirB9
3	Wbm0592	773630..775135 [-], 1506	58584849	monovalent cation/H+ antiporter subunit D
4	Wbm0593	775225..776415 [-], 1191	58584850	queuine/archaeosine tRNA-ribosyltransferase
5	Wbm0594	776416..776916 [-], 501	58584851	NADH dehydrogenase subunit E
Region 3: 986653..989007
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	Wbm0748	983225..983653 [-], 429	58585005	hypothetical protein
2	Wbm0749	983877..986672 [-], 2796	58585006	hypothetical protein
3	Wbm0750	986653..989007 [-], 2355	58585007	Type IV secretory pathway, VirB4 components	VirB4
4	Wbm0751	989038..989415 [-], 378	58585008	hypothetical protein
5	Wbm0752	989526..990761 [-], 1236	58585009	hypothetical protein
6	Wbm0753	990873..991913 [-], 1041	58585010	trans-2-enoyl-ACP reductase, FabK
7	Wbm0754	991919..992392 [-], 474	58585011	cytochrome B561
Region 4: 1051828..1066132
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	Wbm0790 (pyrE)	1047828..1048433 [+], 606	58585047	orotate phosphoribosyltransferase
2	Wbm0791	1050523..1051071 [-], 549	58585048	N-6 adenine-specific DNA methylase
3	Wbm0792	1051188..1051835 [-], 648	58585049	hypothetical protein
4	Wbm0793	1051828..1055067 [-], 3240	58585050	Type IV secretory pathway, VirB6 components	VirB6
5	Wbm0794	1055217..1058339 [-], 3123	58585051	Type IV secretory pathway, VirB6 components	VirB6
6	Wbm0795	1058336..1060738 [-], 2403	58585052	Type IV secretory pathway, VirB6 components
7	Wbm0796	1060804..1063428 [-], 2625	58585053	Type IV secretory pathway, VirB6 components	VirB6
8	Wbm0797	1063421..1065826 [-], 2406	58585054	type IV secretion system ATPase VirB4	VirB4
9	Wbm0798	1065836..1066132 [-], 297	58585055	type IV secretion system protein VirB3	VirB3
10	Wbm0799 (lysK)	1066331..1067770 [+], 1440	58585056	lysyl-tRNA synthetase
11	Wbm0800	1068652..1069641 [-], 990	58585057	glutamine amidotransferase domain-containing protein
12	Wbm0801 (coaD)	1069887..1070390 [+], 504	58585058	phosphopantetheine adenylyltransferase
13	Wbm0802	1070459..1070656 [+], 198	58585059	NADH:ubiquinone oxidoreductase Fe-S subunit

Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files

Proteins        Genes

Effectors

wBm0014, wBm0032, wBm0044, wBm0057, wBm0064, wBm0070, wBm0076, wBm0114, wBm0152, wBm0213, wBm0222, wBm0277, wBm0284, wBm0287, wBm0447

The information of protein effectors
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	*
1	Wbm0014	20371..20991 [+], 621	58584275	cytochrome c biogenesis protein CcmA	wBm0014
2	Wbm0032 (trmE)	41626..42954 [+], 1329	58584293	tRNA modification GTPase TrmE	wBm0032
3	Wbm0044	55843..57120 [-], 1278	58584305	amino acid transporter	wBm0044
4	Wbm0057	77507..77824 [-], 318	58584318	hypothetical protein	wBm0057
5	Wbm0064	85660..86817 [+], 1158	58584325	2-polyprenyl-6-methoxyphenol 4-hydroxylase	wBm0064
6	Wbm0070	92860..94146 [+], 1287	58584331	Mg2+/Co2+ transporter	wBm0070
7	Wbm0076	98390..99568 [+], 1179	58584337	WAS family protein	wBm0076
8	Wbm0114 (def)	148853..149392 [+], 540	58584374	peptide deformylase	wBm0114
9	Wbm0152	192758..193237 [-], 480	58584412	Outer membrane protein, pal-like	wBm0152
10	Wbm0213	283449..284264 [-], 816	58584473	hypothetical protein	wBm0213
11	Wbm0222	294345..294779 [+], 435	58584482	preprotein translocase subunit YajC	wBm0222
12	Wbm0277	362563..363813 [-], 1251	58584535	calcineurin-like phosphoesterase	wBm0277
13	Wbm0284	371438..372283 [+], 846	58584542	Outer surface protein Wsp	wBm0284
14	Wbm0287	376943..377188 [+], 246	58584545	ankyrin repeat-containing protein	wBm0287
15	Wbm0447	581536..584862 [+], 3327	58584704	ankyrin repeat-containing protein	wBm0447

 T4SE derived from experimental literature.

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Proteins        Genes

(1) Turner JD; Langley RS; Johnston KL; Gentil K; Ford L; Wu B; Graham M; Sharpley F; Slatko B; Pearlman E; Taylor MJ (2009). Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem. 284(33):22364-78. [PudMed:19458089]

(2) Foster J; Ganatra M; Kamal I; Ware J; Makarova K; Ivanova N; Bhattacharyya A; Kapatral V; Kumar S; Posfai J; Vincze T; Ingram J; Moran L; Lapidus A; Omelchenko M; Kyrpides N; Ghedin E; Wang S; Goltsman E; Joukov V; Ostrovskaya O; Tsukerman K; Mazur M; Comb D; Koonin E; Slatko B (2005). The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode. PLoS Biol. 3(4):e121. [PudMed:15780005]

This literature contains bioinformatics investigation