T4SS ID	489
Strain	Rickettsia rickettsii str. 'Sheila Smith'
Replicon	chromosome [Browse all T4SS(s) in this replicon]
Accession	NC_009882
Location	134020..151350; 255227..255586; 388822..396700; 1107497..1109929
Name	VirB
Function	effector translocation
Classification	Type IVA; Type P
Bioinformatics investigation has been performed on this T4SS.

T4SS components

Component	VirB1	VirB2	VirB3	VirB4	VirB5	VirB6	VirB7	VirB8	VirB9
Number	0	1	1	2	0	5	0	2	2
Component	VirB10	VirB11	VirD4
Number	1	1	1

The information of T4SS components from NC_009882
Region 1: 134020..151350
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	A1G_00770	129755..130165 [-], 411	157828006	hypothetical protein
2	A1G_00775	130606..130836 [-], 231	157828007	hypothetical protein
3	A1G_00780	130863..131009 [-], 147	157828008	hypothetical protein
4	A1G_00785 (rpmB)	131006..131143 [-], 138	157828009	50S ribosomal protein L28
5	A1G_00790 (rpmB)	131618..131911 [+], 294	157828010	50S ribosomal protein L28
6	A1G_00795	131908..132144 [+], 237	157828011	50S ribosomal protein L31
7	A1G_00800 (engB)	132498..133136 [+], 639	157828012	ribosome biogenesis GTP-binding protein YsxC
8	A1G_00805	133207..134007 [+], 801	157828013	acetylglutamate kinase
9	A1G_00810	134020..134307 [+], 288	157828014	type IV secretion system protein VirB3	VirB3
10	A1G_00815	134523..136940 [+], 2418	157828015	type IV secretion system ATPase VirB4	VirB4
11	A1G_00820	137058..140018 [+], 2961	157828016	hypothetical protein	VirB6
12	A1G_00825	140005..141990 [+], 1986	157828017	hypothetical protein	VirB6
13	A1G_00830	141997..144897 [+], 2901	157828018	hypothetical protein	VirB6
14	A1G_00835	145100..147736 [+], 2637	157828019	hypothetical protein	VirB6
15	A1G_00840	147889..151350 [+], 3462	157828020	hypothetical protein	VirB6
16	A1G_00865 (trmD)	154188..154316 [+], 129	157828021	tRNA (guanine-N(1)-)-methyltransferase
17	A1G_00870	154316..154411 [+], 96	157828022	hypothetical protein
18	A1G_00875 (trmD)	154664..155368 [+], 705	157828023	tRNA (guanine-N(1)-)-methyltransferase
19	A1G_00880 (rplS)	155386..155802 [+], 417	157828024	50S ribosomal protein L19
20	A1G_00885	155972..156208 [-], 237	157828025	hypothetical protein
Region 2: 255227..255586
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	A1G_01345	250612..250890 [+], 279	157828115	hypothetical protein
2	A1G_01350	251031..251372 [-], 342	157828116	hypothetical protein
3	A1G_01355	251540..252013 [+], 474	157828117	hypothetical protein
4	A1G_01360 (holA)	252021..252995 [+], 975	157828118	DNA polymerase III subunit delta
5	A1G_01365	253131..253670 [+], 540	157828119	ubiquinone biosynthesis protein Coq7
6	A1G_01370	254225..254356 [-], 132	157828120	hypothetical protein
7	A1G_01375	254355..255071 [+], 717	157828121	cytochrome c oxidase subunit III
8	A1G_01380	255227..255586 [+], 360	157828122	hypothetical protein	VirB2
9	A1G_01385	255930..256562 [-], 633	157828123	hypothetical protein
10	A1G_01390 (dapD)	256639..257463 [+], 825	157828124	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase
11	A1G_01395	257674..257922 [-], 249	157828125	hypothetical protein
12	A1G_01400	257903..258142 [-], 240	157828126	hypothetical protein
13	A1G_01405	258567..258764 [-], 198	157828127	hypothetical protein
14	A1G_01410	258893..259162 [-], 270	157828128	hypothetical protein
15	A1G_01415	259150..259308 [-], 159	157828129	hypothetical protein
16	A1G_01420	259379..259531 [-], 153	157828130	hypothetical protein
Region 3: 388822..396700
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	A1G_02175	384409..384507 [+], 99	157828256	hypothetical protein
2	A1G_02180	384631..385035 [-], 405	157828257	hypothetical protein
3	A1G_02185	385026..385313 [-], 288	157828258	hypothetical protein
4	A1G_02190	385500..386963 [-], 1464	157828259	putative monovalent cation/H+ antiporter subunit D
5	A1G_02195	387110..388225 [-], 1116	157828260	putative monovalent cation/H+ antiporter subunit D
6	A1G_02200	388408..388743 [-], 336	157828261	putative monovalent cation/H+ antiporter subunit C
7	A1G_02205	388822..389574 [-], 753	157828262	VirB9 protein	VirB9
8	A1G_02210	389576..390274 [-], 699	157828263	virB8 protein	VirB8
9	A1G_02215	390739..390918 [+], 180	157828264	hypothetical protein
10	A1G_02220	390968..391699 [+], 732	157828265	hypothetical protein	VirB8
11	A1G_02225	391686..392159 [+], 474	157828266	virB9 protein	VirB9
12	A1G_02230	392342..393790 [+], 1449	157828267	virB10 protein	VirB10
13	A1G_02235	393787..394791 [+], 1005	157828268	type IV secretion system ATPase VirB11	VirB11
14	A1G_02240	394925..396700 [+], 1776	157828269	type IV secretion system protein VirB8	VirD4
15	A1G_02245	396693..398114 [+], 1422	157828270	guanosine pentaphosphate phosphohydrolase
16	A1G_02250	398328..398639 [-], 312	157828271	hypothetical protein
17	A1G_02255	399575..399814 [-], 240	157828272	hypothetical protein
18	A1G_02270	400518..400802 [-], 285	157828273	hypothetical protein
Region 4: 1107497..1109929
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	Component
1	A1G_06655	1103534..1105075 [+], 1542	157829046	AmpG protein
2	A1G_06660	1105142..1105897 [+], 756	157829047	sec-independent protein translocase protein TatC
3	A1G_06665	1105875..1107152 [+], 1278	157829048	seryl-tRNA synthetase
4	A1G_06670	1107497..1109929 [+], 2433	157829049	virB4 protein	VirB4
5	A1G_06675	1110065..1113553 [+], 3489	157829050	hypothetical protein
6	A1G_06680	1113558..1114463 [+], 906	157829051	tellurium resistance protein TerC

Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files

Proteins        Genes

Effectors

Rickettsia ankyrin repeat protein 2 (RARP-2)

The information of protein effectors
#	Locus tag (Gene)	Coordinates [+/-], size (bp)	Protein GI	Product	*
1	A1G_05165	869777..871627 [-], 1851	157828792	hypothetical protein	Rickettsia ankyrin repeat protein 2 (RARP-2)

 T4SE derived from experimental literature.
 This effector contains information of interaction.

Download FASTA format files

Proteins        Genes

The information on host-pathogen interaction.

#	Name(Protein GI)	Host site/Substrate	Source	Function	Reference
1	RARP-2 (157828792)	Endoplasmic reticulum (ER)	ape	RARP-2 interacts with ER to manipulate the structure of it.	(1) PubMed: 29946049

This T4SE is mentioned in the literature.

(1) Lehman SS et al. (2018). The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum. MBio. 9(3):e00975-18. [PudMed:29946049]

(1) Gillespie JJ; Ammerman NC; Dreher-Lesnick SM; Rahman MS; Worley MJ; Setubal JC; Sobral BS; Azad AF (2009). An anomalous type IV secretion system in Rickettsia is evolutionarily conserved. PLoS One. 4(3):e4833. [PudMed:19279686]

This literature contains bioinformatics investigation