SecReT4
T4SS ID392
StrainXanthomonas axonopodis pv. citri str. 306
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_003919
Location3073334..3089903
NameVirB
Functioneffector translocation
ClassificationType IVA; Type P
experimental Experimental investigation has been performed on this T4SS.
structure Information of structure: structureVirB7, VirB9 C-terminal domain in complex with VirB7 N-terminal domain, Core complex from Xanthomonas citri

T4SS components
ComponentVirB1VirB2VirB3VirB4VirB5VirB6VirB7VirB8VirB9
Number111102011
ComponentVirB10VirB11VirD4
Number111

The information of T4SS components from NC_003919
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1XAC2602 (aglA)3068749..3070365 [-], 161721243333alpha-glucosidase 
2XAC26033070678..3070944 [+], 26721243334ISxac4 transposase 
3XAC26043070968..3071789 [+], 82221243335ISxac4 transposase 
4XAC26053072014..3072457 [-], 44421243336hypothetical protein 
5XAC26063072789..3073280 [-], 49221243337hypothetical protein 
6XAC2607 (virB6)3073334..3073930 [-], 59721243338VirB6 protein  VirB6
7XAC26083073753..3074253 [-], 50121243339VirB6 protein 
8XAC26093074406..3075701 [-], 129621243340carboxypeptidase 
9XAC26103075806..3076609 [-], 80421243341hypothetical protein 
10XAC26113076631..3077125 [-], 49521243342hypothetical protein 
11XAC2612 (virB6)3077157..3078209 [-], 105321243343VirB6 protein  VirB6
12XAC26133078307..3079134 [-], 82821243344hypothetical protein 
13XAC2614 (virB4)3079127..3081580 [-], 245421243345VirB4 protein  VirB4
14XAC2615 (virB3)3081680..3081991 [-], 31221243346VirB3 protein  VirB3
15XAC2616 (virB2)3081984..3082394 [-], 41121243347VirB2 protein  VirB2
16XAC2617 (virB1)3082452..3083294 [-], 84321243348VirB1 protein  VirB1
17XAC2618 (virB11)3083345..3084385 [-], 104121243349VirB11 protein  VirB11
18XAC2619 (virB10)3084400..3085569 [-], 117021243350VirB10 protein  VirB10
19XAC2620 (virB9)3085566..3086333 [-], 76821243351VirB9 protein  VirB9
20XAC2621 (virB8)3086330..3087376 [-], 104721243352VirB8 protein  VirB8
21XAC26223087486..3087905 [-], 42021243353hypothetical protein 
22XAC2623 (virD4)3088230..3089903 [-], 167421243354VirD4 protein  VirD4
23XAC2625 (uvrB)3091075..3093096 [-], 202221243355excinuclease ABC subunit B 
24XAC2626 (fimT)3093250..3093777 [+], 52821243356fimbrial biogenesis protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
XAC2609

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1XAC2609 3074406..3075701 [-], 129621243340carboxypeptidaseexperimental  XAC2609
experimental T4SE derived from experimental literature.

Download FASTA format files
Proteins        Genes
The information on structure of this T4ss

#NameImageResourceDetailReference
1Core complex from Xanthomonas citri6GYB PDB (6GYB)Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri.(1) PubMed: 30349081
2VirB73OV5 PDB (3OV5)Atomic structure of the Xanthomonas citri VirB7 globular domain.(2) PubMed: 21589901
3VirB72L4W PDB (2L4W)NMR structure of the Xanthomonas VirB7.(3) PubMed: 21589901
4VirB9 C-terminal domain in complex with VirB7 N-terminal domain2N01 PDB (2N01)NMR structure of VirB9 C-terminal domain in complex with VirB7 N-terminal domain from Xanthomonas citri's T4SS.(4) PubMed: 27594685
(1) Sgro GG et al. (2018). Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri. Nat Microbiol. 3(12):1429-1440. [PudMed:30349081] experimental
(2) Souza DP; Andrade MO; Alvarez-Martinez CE; Arantes GM; Farah CS; Salinas RK (2011). A component of the Xanthomonadaceae type IV secretion system combines a VirB7 motif with a N0 domain found in outer membrane transport proteins. PLoS Pathog. 7(5):e1002031. [PudMed:21589901] experimental
(3) Souza DP; Andrade MO; Alvarez-Martinez CE; Arantes GM; Farah CS; Salinas RK (2011). A component of the Xanthomonadaceae type IV secretion system combines a VirB7 motif with a N0 domain found in outer membrane transport proteins. PLoS Pathog. 7(5):e1002031. [PudMed:21589901] experimental
(4) Oliveira LC et al. (2016). VirB7 and VirB9 Interactions Are Required for the Assembly and Antibacterial Activity of a Type IV Secretion System. Structure. 24(10):1707-1718. [PudMed:27594685] experimental
(1) Souza DP et al. (2015). Bacterial killing via a type IV secretion system. Nat Commun. 6;6:6453. [PudMed:25743609] experimental
(2) Souza DP; Andrade MO; Alvarez-Martinez CE; Arantes GM; Farah CS; Salinas RK (2011). A component of the Xanthomonadaceae type IV secretion system combines a VirB7 motif with a N0 domain found in outer membrane transport proteins. PLoS Pathog. 7(5):e1002031. [PudMed:21589901] experimental
(3) Alegria MC; Souza DP; Andrade MO; Docena C; Khater L; Ramos CH; da Silva AC; Farah CS (2005). Identification of new protein-protein interactions involving the products of the chromosome- and plasmid-encoded type IV secretion loci of the phytopathogen Xanthomonas axonopodis pv. citri. J Bacteriol. 187(7):2315-25. [PudMed:15774874] experimental
(4) da Silva AC; Ferro JA; Reinach FC; Farah CS; Furlan LR; Quaggio RB; Monteiro-Vitorello CB; Van Sluys MA; Almeida NF; Alves LM; do Amaral AM; Bertolini MC; Camargo LE; Camarotte G; Cannavan F; Cardozo J; Chambergo F; Ciapina LP; Cicarelli RM; Coutinho LL; Cursino-Santos JR; El-Dorry H; Faria JB; Ferreira AJ; Ferreira RC; Ferro MI; Formighieri EF; Franco MC; Greggio CC; Gruber A; Katsuyama AM; Kishi LT; Leite RP; Lemos EG; Lemos MV; Locali EC; Machado MA; Madeira AM; Martinez-Rossi NM; Martins EC; Meidanis J; Menck CF; Miyaki CY; Moon DH; Moreira LM; Novo MT; Okura VK; Oliveira MC; Oliveira VR; Pereira HA; Rossi A; Sena JA; Silva C; de Souza RF; Spinola LA; Takita MA; Tamura RE; Teixeira EC; Tezza RI; Trindade dos Santos M; Truffi D; Tsai SM; White FF; Setubal JC; Kitajima JP (2002). Comparison of the genomes of two Xanthomonas pathogens with differing host specificities. Nature. 417(6887):459-63. [PudMed:12024217]
 
experimental This literature contains experimental investigation

Genomics & Bioinformatics Group in MML, SJTU