Detailed information NTG0994196

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EW024_RS01195
• Genome accession: NZ_LR130237
• Coordinates: 212588..213328 (+)
• Length: 246 a.a.
• NCBI ID: WP_011528222.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain SP444 isolate SP444
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 207588..218328

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW024_RS01180	gltX	208118..209563 (+)	1446	WP_002993289.1	glutamate--tRNA ligase	-
EW024_RS01185	-	209958..211304 (+)	1347	WP_063815444.1	sensor histidine kinase	-
EW024_RS01190	-	211301..212584 (+)	1284	WP_010921869.1	sensor histidine kinase	-
EW024_RS01195	comE/blpR	212588..213328 (+)	741	WP_011528222.1	response regulator transcription factor	Regulator
EW024_RS01200	rnpA	213868..214227 (+)	360	WP_002992035.1	ribonuclease P protein component	-
EW024_RS01205	-	214193..215020 (+)	828	WP_011528223.1	YidC/Oxa1 family membrane protein insertase	-
EW024_RS01210	jag	215032..215946 (+)	915	WP_011528224.1	RNA-binding cell elongation regulator Jag/EloR	-
EW024_RS01215	rpmH	216260..216394 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
EW024_RS01220	-	216669..217373 (+)	705	WP_011528225.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28909.53 Da
• Isoelectric Point: 6.8298

>NTDB_id=994196 EW024_RS01195 WP_011528222.1 212588..213328(+) (comE/blpR) [Streptococcus pyogenes strain SP444 isolate SP444]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTRTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEALR

Nucleotide

• Length: 741 bp

>NTDB_id=994196 EW024_RS01195 WP_011528222.1 212588..213328(+) (comE/blpR) [Streptococcus pyogenes strain SP444 isolate SP444]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCGGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTGGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGATTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGCTCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.903	100	0.382
comE/comE2	Streptococcus gordonii strain NCTC7865	37.903	100	0.382
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37