Detailed information NTG0976734

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS38345_RS00340
• Genome accession: NZ_CP151437
• Coordinates: 53324..54235 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS38345
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48324..59235

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS38345_RS00320 (MGAS38345_00126)	purE	48661..49152 (+)	492	WP_015055884.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS38345_RS00325 (MGAS38345_00128)	purK	49139..50212 (+)	1074	WP_015055885.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS38345_RS00330 (MGAS38345_00130)	-	50239..51882 (+)	1644	WP_010921779.1	AIPR family protein	-
MGAS38345_RS00335 (MGAS38345_00132)	purB	51900..53192 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
MGAS38345_RS00340 (MGAS38345_00134)	comR	53324..54235 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS38345_RS00345 (MGAS38345_00136)	comS	54319..54414 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS38345_RS00350 (MGAS38345_00138)	ruvB	54461..55459 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS38345_RS00355 (MGAS38345_00140)	-	55597..56034 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS38345_RS00360 (MGAS38345_00142)	-	56057..56458 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
MGAS38345_RS00365 (MGAS38345_00144)	-	56455..58230 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=976734 MGAS38345_RS00340 WP_002986681.1 53324..54235(+) (comR) [Streptococcus pyogenes strain MGAS38345]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=976734 MGAS38345_RS00340 WP_002986681.1 53324..54235(+) (comR) [Streptococcus pyogenes strain MGAS38345]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462