Detailed information NTG0097628

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8522_RS02560
• Genome accession: NZ_AP026916
• Coordinates: 499315..499902 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700006
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 494315..504902

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8522_RS02540 (PC0006_05160)	-	494777..496117 (+)	1341	WP_050123659.1	sensor histidine kinase	-
R8522_RS02545 (PC0006_05170)	blpC	496188..496316 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8522_RS02550 (PC0006_05180)	-	496373..497734 (-)	1362	WP_050122537.1	bacteriocin secretion accessory protein	-
R8522_RS02555 (PC0006_05190)	comA/nlmT	497745..499421 (-)	1677	WP_196302068.1	peptide cleavage/export ABC transporter	Regulator
R8522_RS02560 (PC0006_05200)	comA/nlmT	499315..499902 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8522_RS02565 (PC0006_05210)	blpI	500183..500380 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
R8522_RS02570 (PC0006_05230)	blpJ	500847..501116 (+)	270	WP_050122544.1	bacteriocin-like peptide BlpJ	-
R8522_RS02575 (PC0006_05240)	-	501185..501469 (+)	285	WP_050122547.1	Blp family class II bacteriocin	-
R8522_RS02580 (PC0006_05250)	cipB	501713..501862 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R8522_RS02585	-	501966..502085 (+)	120	WP_001833623.1	PncF family bacteriocin immunity protein	-
R8522_RS02590 (PC0006_05270)	-	502567..502925 (+)	359	Protein_511	immunity protein	-
R8522_RS02595	-	503086..504055 (+)	970	Protein_512	thioredoxin domain-containing protein	-
R8522_RS02600 (PC0006_05300)	-	504302..504535 (+)	234	WP_050122549.1	bacteriocin class II family protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=97628 R8522_RS02560 WP_000205166.1 499315..499902(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700006]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=97628 R8522_RS02560 WP_000205166.1 499315..499902(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700006]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497