Detailed information NTG0095401

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: QMM10_RS10520
• Genome accession: NZ_AP025938
• Coordinates: 2074290..2075042 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900701057
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2069290..2080042

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM10_RS10500	-	2071766..2073377 (-)	1612	Protein_2037	YhgE/Pip domain-containing protein	-
QMM10_RS10505 (PC1044_20300)	-	2073505..2074047 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
QMM10_RS10520 (PC1044_20310)	comE	2074290..2075042 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
QMM10_RS10525 (PC1044_20320)	comD/comD2	2075039..2076364 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
QMM10_RS10530	comC/comC2	2076385..2076510 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
QMM10_RS10540 (PC1044_20330)	rlmH	2076792..2077271 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QMM10_RS10545 (PC1044_20340)	htrA	2077454..2078635 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
QMM10_RS10550 (PC1044_20350)	spo0J	2078693..2079451 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=95401 QMM10_RS10520 WP_000866065.1 2074290..2075042(-) (comE) [Streptococcus pneumoniae strain PZ900701057]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=95401 QMM10_RS10520 WP_000866065.1 2074290..2075042(-) (comE) [Streptococcus pneumoniae strain PZ900701057]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408