Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   VKP39_RS00685 Genome accession   NZ_CP142353
Coordinates   105854..106807 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain D641     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100854..111807
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP39_RS00645 (VKP39_00645) - 101681..102046 (+) 366 WP_002986560.1 DUF1033 family protein -
  VKP39_RS00650 (VKP39_00650) comYA 102139..103077 (+) 939 WP_002993471.1 competence type IV pilus ATPase ComGA Machinery gene
  VKP39_RS00655 (VKP39_00655) comYB 103013..104047 (+) 1035 WP_225793059.1 competence type IV pilus assembly protein ComGB Machinery gene
  VKP39_RS00660 (VKP39_00660) comYC 104049..104375 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  VKP39_RS00665 (VKP39_00665) comGD 104350..104778 (+) 429 WP_023605232.1 competence type IV pilus minor pilin ComGD -
  VKP39_RS00670 (VKP39_00670) comGE 104735..105019 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  VKP39_RS00675 (VKP39_00675) comYF 105012..105446 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  VKP39_RS00680 (VKP39_00680) comGG 105430..105756 (+) 327 WP_002992739.1 competence type IV pilus minor pilin ComGG -
  VKP39_RS00685 (VKP39_00685) comYH 105854..106807 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  VKP39_RS00690 (VKP39_00690) - 106866..108062 (+) 1197 WP_109821056.1 acetate kinase -
  VKP39_RS00695 (VKP39_00695) - 108249..108557 (+) 309 WP_032467031.1 hypothetical protein -
  VKP39_RS00700 (VKP39_00700) proC 108640..109410 (-) 771 WP_002992745.1 pyrroline-5-carboxylate reductase -
  VKP39_RS00705 (VKP39_00705) pepA 109458..110525 (-) 1068 WP_109821057.1 glutamyl aminopeptidase -
  VKP39_RS00710 (VKP39_00710) - 110990..111274 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  VKP39_RS00715 (VKP39_00715) - 111271..111588 (+) 318 WP_002986515.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=925141 VKP39_RS00685 WP_002987790.1 105854..106807(+) (comYH) [Streptococcus pyogenes strain D641]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=925141 VKP39_RS00685 WP_002987790.1 105854..106807(+) (comYH) [Streptococcus pyogenes strain D641]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAAATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACACTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656