Detailed information NTG0911580

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: U0450_RS06770
• Genome accession: NZ_CP139863
• Coordinates: 1336232..1337269 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727268.1
• Uniprot ID: A0A0U0L8C3
• Organism: Streptococcus pneumoniae strain 15P2112
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1331232..1342269

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0450_RS06735	yidC	1331267..1332193 (-)	927	WP_000835942.1	membrane protein insertase YidC	-
U0450_RS06740	-	1332271..1332549 (-)	279	WP_001174613.1	acylphosphatase	-
U0450_RS06745	-	1332583..1333323 (+)	741	WP_000152693.1	RNA methyltransferase	-
U0450_RS06750	-	1333379..1334062 (+)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
U0450_RS06755	asnA	1334174..1335166 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
U0450_RS06760	rsmD	1335231..1335770 (+)	540	WP_000706960.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
U0450_RS06765	coaD	1335760..1336248 (+)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
U0450_RS06770	sepM	1336232..1337269 (+)	1038	WP_000727268.1	SepM family pheromone-processing serine protease	Regulator
U0450_RS06775	-	1337327..1337557 (+)	231	WP_000250393.1	DUF1146 family protein	-
U0450_RS06780	murA	1337581..1338864 (+)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
U0450_RS06785	-	1338857..1339045 (+)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
U0450_RS06790	endA	1339084..1339908 (+)	825	WP_001036783.1	DNA-entry nuclease EndA	Machinery gene
U0450_RS06795	-	1340199..1341530 (+)	1332	WP_000390043.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37551.60 Da
• Isoelectric Point: 5.0724

>NTDB_id=911580 U0450_RS06770 WP_000727268.1 1336232..1337269(+) (sepM) [Streptococcus pneumoniae strain 15P2112]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKINDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=911580 U0450_RS06770 WP_000727268.1 1336232..1337269(+) (sepM) [Streptococcus pneumoniae strain 15P2112]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAATAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTAGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

• PDZ domain (PDZ_2) (130-193)

3D structure

• AlphaFold DB: A0A0U0L8C3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.357	99.13	0.588