NTDB

Overview

Name	comA/nlmT	Type	Regulator
Locus tag	R4704_RS08230	Genome accession	NZ_CP137109
Coordinates	1577552..1578139 (-)	Length	195 a.a.
NCBI ID	WP_000205166.1	Uniprot ID	Q9ETN5
Organism	Streptococcus pneumoniae strain 11012
Function	transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1572552..1583139

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4704_RS08210	-	1573013..1574353 (+)	1341	WP_000275285.1	sensor histidine kinase	-
R4704_RS08215	blpC	1574398..1574553 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
R4704_RS08220	-	1574610..1575971 (-)	1362	WP_033705510.1	bacteriocin secretion accessory protein	-
R4704_RS08225	comA/nlmT	1575982..1577658 (-)	1677	WP_317830619.1	peptide cleavage/export ABC transporter	Regulator
R4704_RS08230	comA/nlmT	1577552..1578139 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4704_RS08235	blpM	1578478..1578732 (+)	255	WP_033705509.1	two-peptide bacteriocin subunit BlpM	-
R4704_RS08240	blpN	1578748..1578951 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
R4704_RS08245	cipB	1579195..1579344 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R4704_RS08250	-	1579448..1579567 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R4704_RS08255	-	1580035..1580406 (+)	372	WP_033705507.1	hypothetical protein	-
R4704_RS08260	-	1580567..1581536 (+)	970	Protein_1586	thioredoxin domain-containing protein	-
R4704_RS08265	-	1581783..1582016 (+)	234	WP_033705506.1	bacteriocin class II family protein	-
R4704_RS08270	-	1582048..1582737 (+)	690	WP_033705505.1	CPBP family intramembrane glutamic endopeptidase	-
R4704_RS08275	blpZ	1582779..1583027 (+)	249	WP_000276506.1	immunity protein BlpZ	-

Sequence

Protein

Download Length: 195 a.a. Molecular weight: 22270.71 Da Isoelectric Point: 9.6188

                                >NTDB_id=895823 R4704_RS08230 WP_000205166.1 1577552..1578139(-) (comA/nlmT) [Streptococcus pneumoniae strain 11012]

MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV

PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS

SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

Download Length: 588 bp

                                >NTDB_id=895823 R4704_RS08230 WP_000205166.1 1577552..1578139(-) (comA/nlmT) [Streptococcus pneumoniae strain 11012]

ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA

ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA

TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC

CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA

TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG

TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC

TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT

CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q9ETN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497

Detailed information NTG0895823