Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R3H37_RS01370 Genome accession   NZ_CP136948
Coordinates   254949..255710 (+) Length   253 a.a.
NCBI ID   WP_111713597.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Spyo01     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 249949..260710
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS01355 (R3H37_01355) - 250207..251775 (-) 1569 WP_063631512.1 ABC transporter substrate-binding protein/permease -
  R3H37_RS01360 (R3H37_01360) - 251973..253898 (+) 1926 WP_136292443.1 DUF2207 domain-containing protein -
  R3H37_RS01365 (R3H37_01365) - 253964..254803 (+) 840 WP_002986031.1 undecaprenyl-diphosphate phosphatase -
  R3H37_RS01370 (R3H37_01370) mecA 254949..255710 (+) 762 WP_111713597.1 adaptor protein MecA Regulator
  R3H37_RS01375 (R3H37_01375) - 255717..256886 (+) 1170 WP_136107950.1 glycosyltransferase family 4 protein -
  R3H37_RS01380 (R3H37_01380) sufC 257008..257778 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  R3H37_RS01385 (R3H37_01385) sufD 257873..259135 (+) 1263 WP_136038737.1 Fe-S cluster assembly protein SufD -
  R3H37_RS01390 (R3H37_01390) - 259166..260392 (+) 1227 WP_011054183.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29067.77 Da        Isoelectric Point: 4.1622

>NTDB_id=893588 R3H37_RS01370 WP_111713597.1 254949..255710(+) (mecA) [Streptococcus pyogenes strain Spyo01]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEKIEEIMEDVVEATLANQSEAADPSTNHESELLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=893588 R3H37_RS01370 WP_111713597.1 254949..255710(+) (mecA) [Streptococcus pyogenes strain Spyo01]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAAGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAAAAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACTTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

47.843

100

0.482
  mecA Streptococcus pneumoniae D39

47.843

100

0.482
  mecA Streptococcus pneumoniae R6

47.843

100

0.482
  mecA Streptococcus pneumoniae TIGR4

47.843

100

0.482