Detailed information NTG0885092

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: RMP66_RS05150
• Genome accession: NZ_CP135094
• Coordinates: 1039470..1040141 (+)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain 1547095
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1034470..1045141

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RMP66_RS05120 (RMP66_05120)	pstC	1034698..1035615 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
RMP66_RS05125 (RMP66_05125)	pstA	1035605..1036492 (+)	888	WP_248022956.1	phosphate ABC transporter permease PstA	-
RMP66_RS05130 (RMP66_05130)	pstB	1036517..1037320 (+)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
RMP66_RS05135 (RMP66_05135)	pstB	1037332..1038090 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
RMP66_RS05140 (RMP66_05140)	phoU	1038119..1038775 (+)	657	WP_024394630.1	phosphate signaling complex protein PhoU	-
RMP66_RS10790	-	1038941..1039276 (+)	336	Protein_974	hypothetical protein	-
RMP66_RS05150 (RMP66_05150)	ciaR	1039470..1040141 (+)	672	WP_024385291.1	response regulator transcription factor	Regulator
RMP66_RS05155 (RMP66_05155)	ciaH	1040134..1041513 (+)	1380	WP_024394629.1	cell wall metabolism sensor histidine kinase WalK	Regulator
RMP66_RS05160 (RMP66_05160)	-	1041837..1043066 (+)	1230	WP_313910540.1	transglutaminase domain-containing protein	-
RMP66_RS05165 (RMP66_05165)	rpsT	1043328..1043576 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
RMP66_RS05170 (RMP66_05170)	coaA	1043635..1044555 (-)	921	WP_024381359.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=885092 RMP66_RS05150 WP_024385291.1 1039470..1040141(+) (ciaR) [Streptococcus suis strain 1547095]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=885092 RMP66_RS05150 WP_024385291.1 1039470..1040141(+) (ciaR) [Streptococcus suis strain 1547095]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACGAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368