Detailed information NTG0863946

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: Q7625_RS02305
• Genome accession: NZ_CP131708
• Coordinates: 450597..451334 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 2016C10-332
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 445597..456334

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7625_RS02270 (Q7625_02270)	-	446483..446767 (-)	285	WP_025169639.1	hypothetical protein	-
Q7625_RS02275 (Q7625_02275)	-	446929..447216 (-)	288	WP_000777753.1	hypothetical protein	-
Q7625_RS02280 (Q7625_02280)	-	447226..447636 (-)	411	WP_001278301.1	HIT family protein	-
Q7625_RS02285 (Q7625_02285)	pptA	447704..448435 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
Q7625_RS02290 (Q7625_02290)	-	448432..449481 (+)	1050	WP_000653774.1	ABC transporter permease	-
Q7625_RS02295 (Q7625_02295)	-	449649..449978 (-)	330	WP_000132572.1	hypothetical protein	-
Q7625_RS02300 (Q7625_02300)	-	450254..450592 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
Q7625_RS02305 (Q7625_02305)	comE/blpR	450597..451334 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
Q7625_RS02310 (Q7625_02310)	-	451348..452688 (+)	1341	WP_001017642.1	sensor histidine kinase	-
Q7625_RS02315 (Q7625_02315)	blpC	452759..452887 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
Q7625_RS02320 (Q7625_02320)	-	452944..454305 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
Q7625_RS02325 (Q7625_02325)	comA/nlmT	454316..455992 (-)	1677	WP_196300924.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=863946 Q7625_RS02305 WP_001219120.1 450597..451334(+) (comE/blpR) [Streptococcus pneumoniae strain 2016C10-332]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=863946 Q7625_RS02305 WP_001219120.1 450597..451334(+) (comE/blpR) [Streptococcus pneumoniae strain 2016C10-332]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363